A5020650316- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Vascular Anomalies and Treatments
- Hormonal Regulation and Hypertension
- Drug-Induced Hepatotoxicity and Protection
- Tracheal and airway disorders
- Alcohol Consumption and Health Effects
- Venous Thromboembolism Diagnosis and Management
- Liver physiology and pathology
- Electrolyte and hormonal disorders
- Hepatitis Viruses Studies and Epidemiology
- Otitis Media and Relapsing Polychondritis
- Pulmonary Hypertension Research and Treatments
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Vascular Malformations Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Peripheral Artery Disease Management
- Gastrointestinal Bleeding Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Sharing Economy and Platforms
- Hemostasis and retained surgical items
- Inflammatory Biomarkers in Disease Prognosis
- Intracranial Aneurysms: Treatment and Complications
Odense University Hospital
2016-2025
University of Southern Denmark
2015-2023
Minnesota Gastroenterology
2007-2019
Hospital South West Jutland
2015
•Total cross-sectional SPSS area (TSA) predicts survival in patients with advanced chronic liver disease.•The cut-off for TSA that is associated worse corresponds to a single shunt of >10 mm diameter.•This study may impact on the clinical use TSA/SPSS risk stratification and decision-making management cirrhosis. Background & AimsSpontaneous portosystemic shunts (SPSS) frequently develop Recent data suggested presence large complications, especially overt hepatic encephalopathy (oHE)....
Knowledge on the prognosis among patients with cirrhosis is mainly based clinical trials selected patient groups as well population-based register studies suboptimal diagnostic reliability. The aim of study was to describe incidence, etiology, and mortality well-validated cirrhotic cases in a cohort at Funen (population 470,000) between 1996 2006.A case identification from discharge diagnosis followed by manual validation records inclusion that fulfilled predefined criteria.4010 possible...
Hereditary haemorrhagic telangiectasia (HHT) is a complex, multisystemic vascular dysplasia affecting approximately 85,000 European Citizens. In 2016, eight founding centres operating within 6 countries, set up working group dedicated to HHT what became the Reference Network on Rare Multisystemic Vascular Diseases. By launch, combined experience exceeded 10,000 patients, and Chairs representing 7 separate specialties provided median of 24 years' in HHT. Integrated were expert patients who...
Hereditary haemorrhagic telangiectasia (HHT) is a rare vascular multisystemic disease that leads to epistaxis, anaemia due blood loss, and arteriovenous malformations (AVMs) in organs such as the lungs, liver brain. HHT prevalence estimated at 1/6000, i.e. around 85,000 European citizens, served by Reference Network for Rare Multisystemic Vascular Diseases (VASCERN). treatments depend on clinical manifestations, span multiple different medical, surgical interventional disciplines. Separate...
Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular dysplasia resulting in visceral arteriovenous malformations and smaller mucocutaneous telangiectasia. Most patients experience recurrent nosebleeds become anemic without iron supplementation. However, thousands may require anticoagulation for conditions such as venous thromboembolism and/or atrial fibrillation. Over decades, tolerance data has been published almost 200 HHT-affected users of warfarin heparins, but there are no the...
Abstract Hereditary haemorrhagic telangiectasia (HHT) is a multisystemic vascular dysplasia inherited as an autosomal dominant trait. Approximately 10 % of patients have cerebral malformations, proportion being arteriovenous malformations (AVMs) and fistulae that may lead to potentially devastating consequences in case rupture. On the other hand, detection treatment related-risks are not negligible, immediate. While successful can be undertaken individual cases, current data do support...
Results from previous studies regarding platelet function in liver cirrhosis are discordant. The aim was to investigate activation and aggregation patients with alcoholic cirrhosis. We included 27 22 healthy individuals. A recently established flow cytometric approach used measure independent of sample count. Platelet further investigated using light transmission aggregometry (LTA) (for count >100 × 109/L). agonists were adenosine diphosphate, thrombin receptor-activating peptide,...
Portal hypertension is usually seen because of liver cirrhosis, causing a plethora symptoms such as ascites and oesophageal varices. However, altered hepatic vasculature can affect the portal venous pressure thereby cause hypertension, giving rise to similar symptomology. This paper presents case recurring severe gastrointestinal (GI) bleeding, varices in patient with arteriovenous malformations (HAVM). Physical examination, biopsy, clinical imaging genetic testing disproved hereditary...
<title>Abstract</title> Background Hereditary Haemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by mucocutaneous telangiectasias and arteriovenous malformations (AVMs) in internal organs. It mainly caused heterozygous pathogenic variants <italic>ENG</italic>, <italic>ACVRL1</italic> or <italic>SMAD4</italic>. Somatic mosaic mutations the functional allele of HHT-causing genes have been identified skin AVMs HHT patients, which suspected to drive...
Abstract The calcium-activated potassium channel KCa3.1 controls different cellular processes such as proliferation and volume homeostasis. We investigated the role of in experimental human liver fibrosis. gene expression was healthy injured rodent liver. Effect genetic depletion pharmacological inhibition evaluated mice during carbon tetrachloride induced hepatic fibrogenesis. Transcription, protein localisation analysed by reverse transcription polymerase chain reaction, Western blot...
Acute kidney injury and hepatorenal syndrome (HRS) are frequent complications in patients with cirrhosis ascites. First-line treatment is terlipressin, which reverses HRS ~40% of but also lowers cardiac output (CO). We aimed to investigate whether reversing the cardio-suppressive effect terlipressin β-adrenoceptor agonist dobutamine would increase CO thereby glomerular filtration rate (GFR). randomized 25 cirrhosis, ascites, impaired renal function (2:2:1): group A received followed by...
Sodium retention in cirrhosis is associated with changes the renin-angiotensin-aldosterone system (RAAS), sympathetic nervous (SNS), and glomerular filtration rate (GFR). We hypothesized that acute reactions of RAAS SNS to volume expansion are qualitatively intact, but occurring from elevated baseline levels. Acute cardiovascular, neurohumoral renal responses central blood were studied cirrhotic patients healthy controls. In patients, plasma renin concentration (PRC) was 5-fold compared...
Abstract Background This report addresses how patients with hereditary hemorrhagic telangiectasia (HHT) and high output cardiac failure (HOCF) due to hepatic vascular malformations, should be evaluated could treated. HHT is a genetic disorder, leading abnormalities potentially serious clinical implications. In the liver, arteriovenous malformations occur in more than 70% of patients, but only about 8% present symptoms such as HOCF pulmonary hypertension less commonly portal hypertension,...
Liver cirrhosis is characterized by avid sodium retention where the activation of renin angiotensin aldosterone system (RAAS) considered to be hallmark retaining mechanisms. The direct effect II (ANGII) on AT-1 receptor in proximal tubules partly responsible for retention. aim was estimate natriuretic and neurohumoral effects an ANGII antagonist (losartan) late phase disease a rat model liver cirrhosis. Bile duct ligated (BDL) sham operated rats received 2 weeks treatment with losartan 4...
Abstract Background Patients with the rare disease; Hereditary haemorrhagic telangiectasia (HHT) often bleed from telangiectatic lesions in mucosal surfaces. Studies suggest that impaired platelet function may also play a role their bleeding tendency. The aim of present study was to investigate whether HHT-patients epistaxis have function. Method We conducted case–control based on sample size calculation and included 22 (inclusion criteria: severity score ≥ 4, no intake medicine affecting...
Fraction of exhaled nitric oxide with an expiratory flow 50 mL/s (FENO50) is a biomarker eosinophilic airway inflammation. Liver transplant recipients have increased risk pulmonary infections, but little known about the burden chronic diseases in this group. We aimed to assess prevalence elevated FENO50 liver and compare it controls from general population. was measured 271 The Danish Comorbidity Transplant Recipients (DACOLT) study 1,018 age- sex-matched Copenhagen General Population Study...