A5060250644- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Pancreatic function and diabetes
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- SARS-CoV-2 and COVID-19 Research
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Animal Virus Infections Studies
- Bone Metabolism and Diseases
- Blood Pressure and Hypertension Studies
- Radiation Dose and Imaging
- Metabolism, Diabetes, and Cancer
- Cardiovascular and exercise physiology
- Bone health and osteoporosis research
- Ultrasound in Clinical Applications
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
- Diabetes Management and Research
- Cardiovascular Disease and Adiposity
Odense University Hospital
2015-2024
Rigshospitalet
2009-2024
University of Southern Denmark
2009-2023
Aarhus University
2023
North Karelia Center for Public Health
2021
Aarhus University Hospital
2016
Lillebaelt Hospital
2014
Mayo Clinic in Florida
2013
Vejle Sygehus
2013
Mayo Clinic in Arizona
2013
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve outcomes in patients with heart failure and a reduced ejection fraction (HFrEF). The association cardiac remodeling has not been investigated.To investigate the outcome of SGLT2i empagliflozin, compared placebo, on HFrEF.This exploratory post hoc analysis included participants stable HFrEF fractions 40% or less, who were randomly enrolled an investigator-initiated, multicenter, double-blind, placebo-controlled randomized clinical...
Global longitudinal systolic strain (GLS) is often reduced in aortic stenosis despite normal ejection fraction. The importance of preoperative GLS on long-term outcome after valve replacement unknown.A total 125 patients with severe and fraction >40% scheduled for were evaluated preoperatively divided into 4 groups according to quartiles. Patients followed up years. primary end points major adverse cardiac events (MACEs) defined as cardiovascular mortality hospitalization because worsening...
To investigate the effect of sodium-glucose co-transporter-2 inhibitor empagliflozin on N-terminal pro-b-type natriuretic peptide (NT-proBNP) in patients with heart failure (HF) and reduced ejection fraction (HFrEF). Empire HF was an investigator-initiated, multi-center, double-blinded, placebo-controlled, randomized trial. Patients mildly symptomatic HFrEF, mean (standard deviation (SD)) age 64 (11) years, 85% male, left ventricular 29% (8), recommended therapy were assigned to receive...
It remains unknown whether the consistently observed increase in haematocrit with sodium-glucose cotransporter 2 inhibitors is caused by diuresis-associated haemoconcentration or increased erythropoiesis. We aimed to investigate early effect of empagliflozin on erythropoiesis and iron metabolism patients heart failure reduced ejection fraction (HFrEF).The Empire HF was a double-blind, randomized, placebo-controlled trial. Patients left ventricular (LVEF) ≤40%, New York Heart Association...
Background— Although type 2 diabetes mellitus is a risk factor for developing congestive heart failure, the mechanism leading to failure unclear. We examined prevalence of left ventricular (LV) systolic and diastolic dysfunction in patients with relation vascular function myocardial perfusion. Methods Results— A prospective observational study 305 (diabetes duration, 4.5�5.3 years) referred consecutively clinic were screened LV by echocardiography. Vascular was estimated using noninvasive...
Plasma calprotectin is a potential biomarker of cardiovascular disease (CVD), insulin resistance (IR), and obesity. We examined the relationship between plasma concentrations, CVD manifestations metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM) order to evaluate as risk assessor diabetic without known CVD. An automated immunoassay for determination was developed based on fecal Calprotectin ELIA, reference range established from 120 healthy adults. concentrations were...
BACKGROUND Extracellular matrix alterations are important elements in the arterial changes seen diabetes, being associated with increased vascular stiffness and development of cardiovascular diseases. However, no biomarkers for diabetes-related have been defined. METHODS Mammary artery specimens from 17 men type 2 diabetes 18 nondiabetic individuals were used microarray expression profiling, quantitative real-time PCR, immunoassay, immunohistochemical analyses. A derived candidate marker,...
In aortic valve stenosis (AS), the occurrence of heart failure symptoms does not always correlate with severity and left ventricular (LV) function. Therefore, we tested hypothesis that symptomatic patients AS have impaired diastolic, longitudinal systolic function, atrial dilatation compared asymptomatic patients.In a retrospective descriptive study, clinical characteristics echocardiographic parameters in 99 139 severe LV ejection fraction ≥50%. Independent predictors state were identified...
Data from recent cardiovascular outcome trials in patients with type 2 diabetes (T2D) suggest that sodium-glucose cotransporter (SGLT2) inhibitors can prevent development of heart failure (HF) and prolong life without HF. Ongoing event-driven are investigating whether the same effect is present well-defined The mechanism behind SGLT2 T2D potential overt HF presently unknown. This a randomized, double-blinded, placebo-controlled, parallel group, clinical trial including reduced left...
Stressed blood volume (SBV) is a major determinant of systemic and pulmonary venous pressures which, in turn, determine left right ventricular fillings regulates cardiac output via the Frank-Starling mechanism. It not known whether inhibition SGLT2 (sodium-glucose cotransporter-2) favorably affects SBV. We investigated effect empagliflozin on estimated SBV patients with heart failure reduced ejection fraction compared placebo.This was post hoc analysis an investigator-initiated,...
We studied factors related to humoral response in solid organ transplant (SOT) recipients following a three-dose regimen of an mRNA-based SARS-CoV-2 vaccine.This was prospective study SOT who received third homologous dose the BNT162b2 (Pfizer-BioNTech) vaccine. The anti-spike S1 IgG measured using II Quant assay (Abbott Laboratories) with cut-off 7.1 BAU/mL. Multiple logistic regression used determine associated response.In total, 395 were included. Anti-spike detected 195/395 (49.4%)...
BackgroundPrevalence of pulmonary embolism (PE) in patients referred to diagnostic imaging is decreasing, indicating a need for improving patient selection. The aim this study was assess reduction referral by integrating bespoke ultrasound protocol and describe associated failure rate adverse events with suspected PE.MethodsIn randomized open-label multicentre trial spanning June 18, 2021, through Feb 1, 2023, adult PE 1) Wells score 0–6 elevated age-adjusted D-dimer or 2) >6 were randomly...
Type 2 diabetes is caused by reduced insulin secretion and resistance in skeletal muscle liver. We tested the combination therapy with aspart, rosiglitazone, metformin purpose of treating all three defects order to test hypothesis that this "triple therapy" will normalize glucose metabolism.Sixteen obese type diabetic outpatients on human NPH or MIX (regular + insulin) twice daily were randomized either triple therapy, i.e., aspart (a rapid-acting analog) at meals, (which improves hepatic...
Cardiovascular disease (CVD) is frequent in type 2 diabetes mellitus patients due to accelerated atherosclerosis. Plasma osteoprotegerin (OPG) has evolved as a biomarker for CVD. We examined the relationship between plasma OPG levels and different CVD manifestations diabetes. Type without known referred consecutively clinic first time (n = 305, aged: 58.6 ± 11.3 years, duration: 4.5 5.3 years) were screened carotid arterial disease, peripheral myocardial ischemia by means of artery...
Abstract Aims Heart failure (HF) is an increasing concern worldwide. A rising HF burden expected due to the prospected future demographic changes with aging populations. Consequently, long‐term follow‐up and treatment will be performed increasingly by primary care physicians in future. Contemporary data on patients are needed plan ensure effective safe of patients. Methods results The electronic patient journals 148 clinics Denmark were searched a standardized manner identify [code K77...