A5050798633- Retinal Diseases and Treatments
- Bone health and osteoporosis research
- Retinal Imaging and Analysis
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Birth, Development, and Health
- Hip and Femur Fractures
- Multiple Myeloma Research and Treatments
- Patient-Provider Communication in Healthcare
- Cancer Treatment and Pharmacology
- Cancer survivorship and care
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Gastric Cancer Management and Outcomes
- Religion, Spirituality, and Psychology
- Blood groups and transfusion
- Chronic Disease Management Strategies
- Assisted Reproductive Technology and Twin Pregnancy
- Palliative Care and End-of-Life Issues
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Colorectal Cancer Screening and Detection
- Rheumatoid Arthritis Research and Therapies
- Patient Satisfaction in Healthcare
University of Southern Denmark
2016-2025
Odense University Hospital
2016-2025
Rigshospitalet
2022-2024
Aarhus University Hospital
2020-2024
Region of Southern Denmark
2024
Kolding Hospital
2024
University of Edinburgh
2024
Ringsted Sygehus
2024
Copenhagen University Hospital
2022-2024
Danish Multiple Sclerosis Center
2024
<h3>Importance</h3> Estimates of familial cancer risk from population-based studies are essential components prediction. <h3>Objective</h3> To estimate and heritability types in a large twin cohort. <h3>Design, Setting, Participants</h3> Prospective study 80 309 monozygotic 123 382 same-sex dizygotic individuals (N = 203 691) within the registers Denmark, Finland, Norway, Sweden. Twins were followed up median 32 years between 1943 2010. There 50 990 who died any cause, 3804 emigrated lost to...
<h3>Background</h3> Leucocyte telomere length (LTL) is a complex trait associated with ageing and longevity. LTL dynamics are defined by its age-dependent attrition. Strong, but indirect evidence suggests that at birth attrition during childhood largely explains interindividual variation among adults. A number of studies have estimated the heritability LTL, none has assessed <h3>Methods</h3> We examined based on longitudinal evaluation (an average follow-up 12 years) in 355 monozygotic 297...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve outcomes in patients with heart failure and a reduced ejection fraction (HFrEF). The association cardiac remodeling has not been investigated.To investigate the outcome of SGLT2i empagliflozin, compared placebo, on HFrEF.This exploratory post hoc analysis included participants stable HFrEF fractions 40% or less, who were randomly enrolled an investigator-initiated, multicenter, double-blind, placebo-controlled randomized clinical...
We assessed the performance of newly released AI GPT-4 in diagnosing complex medical case challenges and compared success rate to that medical-journal readers. correctly diagnosed 57% cases, outperforming 99.98% simulated human readers generated from online answers. highlight potential for be a powerful supportive tool diagnosis; however, further improvements, validation, addressing ethical considerations are needed before clinical implementation. (No funding was obtained this study.)
Abstract Background Nonarteritic anterior ischemic optic neuropathy (NAION) is an untreatable condition often causing severe and irreversible visual loss in the affected eye. As it has recently been implied that use of semaglutide associates with NAION, aim present study was to evaluate this risk prospectively all persons type 2 diabetes (T2D) Denmark. Methods In a five-year longitudinal cohort study, we identified T2D Denmark ( n = 424,152) between 2018 2024. Patients were stratified...
In this article, we report on the results of two online brainstormings that have collected over 480 and 219 guiding distinctions social theory, respectively. We draw these as well a quantitative analysis Top 100 sociological groundworks listed in ISA Books XX Century ranking to identify most influential theory show bulk consists ‘false’ or analogue distinctions. further demonstrate how systematic explorations distinction may facilitate still pending digital transformation defined (a)...
ABSTRACT Background Vacuum‐assisted abdominal closure (VAC) is being increasingly used as an adjunctive procedure in the surgical treatment of secondary peritonitis. This study compared postoperative mortality and complication rates between VAC primary (PAC). Method retrospective chart review included all patients diagnosed with peritonitis who underwent laparotomy 2010 2019. Data were collected from six hospitals within Southern Denmark, covering a population approximately 1,225,000...
Microbial communities growing in laboratory-based flow chambers were investigated order to study compartmentalization of specific gene expression. Among the community members studied, focus was particular on Pseudomonas putida and a strain an Acinetobacter sp., genes studied are involved biodegradation toluene related aromatic compounds. The upper-pathway promoter (Pu) meta-pathway (Pm) from TOL plasmid fused independently coding for green fluorescent protein (GFP), expression these...
ABSTRACT Conjugational transfer of the TOL plasmid (pWWO) was analyzed in a flow chamber biofilm community engaged benzyl alcohol degradation. The consisted three species, Pseudomonas putida RI, Acinetobacter sp. strain C6, and an unidentified isolate, D8. Only P. RI could act as recipient for plasmid. Cells carrying chromosomally integrated lacI q gene lacp-gfp -tagged version were introduced donor strains after its formation. occurrence plasmid-carrying cells by viable-count-based...
As a representative member of the toluene-degrading population in biofilter for waste gas treatment, Pseudomonas putida was investigated with 16S rRNA targeting probe. The three-dimensional distribution P. visualized biofilm matrix by scanning confocal laser microscopy, demonstrating that present throughout biofilm. Acridine orange staining revealed very heterogeneous structure fully hydrated biofilm, cell-free channels extending from surface into This indicated toluene may penetrate to...
Abstract Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ sex, age global regions lacking. We conducted an individual-based pooled analysis 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion height explained shared factors was greatest in early childhood, these effects remained present until adulthood. Accordingly, the relative contribution...
Abstract Background: Family history is an established risk factor for breast cancer. Although some important genetic factors have been identified, the extent to which familial can be attributed versus common environment remains unclear. Methods: We estimated concordance and heritability of cancer among 21,054 monozygotic 30,939 dizygotic female twin pairs from Nordic Twin Study Cancer, largest study in world. accounted left-censoring, right-censoring, as well competing death. Results: From...
Objectives Although causality remains to be established, targeting dysbiosis of the intestinal microbiota by faecal transplantation (FMT) has been proposed as a novel treatment for inflammatory diseases. In this exploratory, proof-of-concept study, we evaluated safety and efficacy FMT in psoriatic arthritis (PsA). Methods double-blind, parallel-group, placebo-controlled, superiority trial, randomly allocated (1:1) adults with active peripheral PsA (≥3 swollen joints) despite ongoing...
Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in inhibition arterial calcification and has been suggested to reduce progression rate aortic valve (AVC) patients with stenosis.In randomized, double-blind, multicenter trial, men from community an AVC score >300 arbitrary units (AU) on cardiac noncontrast computer tomography were randomized daily treatment tablet 720 µg MK-7 plus 25 D or matching placebo 24 months. The primary outcome...
Adherence to topical psoriasis treatments is low, which leads unsatisfactory treatment results. Smartphone applications (apps) for patient support exist but their potential improve adherence has not been systematically evaluated.To evaluate whether a study-specific app improves and reduces symptoms compared with standard treatment.We conducted randomized controlled trial (RCT, clinicaltrials.gov registration: NCT02858713). Patients received once-daily medication [calcipotriol/betamethasone...
Chronic inflammatory diseases in childhood and early adult life share aetiological factors operating from birth onwards. In this study, we use data the national Danish health registers to evaluate risk of developing four common, immune-mediated hospital-diagnosed chronic diseases.A population-based registry study. Data Medical Birth Registry National Patient January 1973 March 2016 were linked at a personal level any potential associations between caesarean section development Inflammatory...