A5068458248- Clostridium difficile and Clostridium perfringens research
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- Vibrio bacteria research studies
- Gut microbiota and health
- Escherichia coli research studies
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Legionella and Acanthamoeba research
- Listeria monocytogenes in Food Safety
- Mycobacterium research and diagnosis
- Yersinia bacterium, plague, ectoparasites research
- Spectroscopy and Chemometric Analyses
- Anesthesia and Pain Management
- Diphtheria, Corynebacterium, and Tetanus
- Clinical Laboratory Practices and Quality Control
- Spinal Hematomas and Complications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Bacteriophages and microbial interactions
- Ocular Infections and Treatments
- Veterinary medicine and infectious diseases
- Helicobacter pylori-related gastroenterology studies
- Gender Politics and Representation
- Actinomycetales infections and treatment
Odense University Hospital
2011-2023
Statens Serum Institut
2004-2023
University of Copenhagen
2023
Zealand University Hospital Køge
2023
Gentofte Hospital
2023
Czech Academy of Sciences, Institute of Microbiology
2016-2017
John Radcliffe Hospital
2004
Summary Background : The herbal preparation, aloe vera, has been claimed to have anti‐inflammatory effects and, despite a lack of evidence its therapeutic efficacy, is widely used by patients with inflammatory bowel disease. Aim To perform double‐blind, randomized, placebo‐controlled trial the efficacy and safety vera gel for treatment mildly moderately active ulcerative colitis. Methods Forty‐four evaluable hospital out‐patients were randomly given oral or placebo, 100 mL twice daily 4...
Objectives Although causality remains to be established, targeting dysbiosis of the intestinal microbiota by faecal transplantation (FMT) has been proposed as a novel treatment for inflammatory diseases. In this exploratory, proof-of-concept study, we evaluated safety and efficacy FMT in psoriatic arthritis (PsA). Methods double-blind, parallel-group, placebo-controlled, superiority trial, randomly allocated (1:1) adults with active peripheral PsA (≥3 swollen joints) despite ongoing...
An unbalanced intestinal microbiota may mediate activation of the inflammatory pathways seen in psoriatic arthritis (PsA). A randomised, placebo-controlled trial faecal transplantation (FMT) infused into small intestine patients with PsA active peripheral disease who are non-responsive to methotrexate (MTX) treatment will be conducted. The objective is explore clinical aspects associated FMT performed PsA.This a two-centre stratified, double-blind (patient, care provider and outcome...
ABSTRACT A comparison between conventional identification and 16S rRNA gene sequencing of anaerobic bacteria isolated from blood cultures in a routine setting was performed ( n = 127). With sequencing, 89% were identified to the species level, versus 52% with identification. The times for 1.5 days 2.8 days, respectively.
Abstract Purpose To analyze the nationwide incidence of Salmonella infections in Denmark from 2013 to 2022. Methods Confirmed cases enterica subsp. were examined using National Register Enteric Pathogens during 2013–2022. Proportions, rates (IR), relative risk (RR), and 95% confidence intervals (CI) calculated assess differences serotypes, invasiveness, age, sex, travel exposure. Results We identified 9,944 Danish cases, with an average annual rate 16.9 per 100,000 inhabitants, declining...
We present five cases of Solobacterium moorei bacteremia. The isolates were identified with 16S rRNA gene sequencing and susceptible to common antibiotics used for anaerobic infections. Bacteremia S. seems be associated debilitating conditions, but the prognosis infection appears good.
Background Campylobacter is one of the most frequent causes bacterial gastroenteritis. outbreaks are rarely reported, which could be a reflection surveillance without routine molecular typing. We have previously shown that numerous small outbreak-like clusters can detected when whole genome sequencing (WGS) data clinical isolates was applied. Aim Typing-based infections initiated in 2019 to enable detection large and match them concurrent retail chicken order react on ongoing outbreaks....
Between November and December 2021, the first ever recorded outbreak of enteroinvasive Escherichia coli in Denmark occurred at national scale. We describe investigation this outbreak, which was initially recognised early 2021. A total 88 cases (58 female; 30 male) with a median age 52 years (range: 0-91) were detected by PCR-based diagnostic methods. Case ascertainment complicated current culture-free procedures, only 34 confirmed culture, serotyping whole genome sequencing. Isolates from...
During 2010-2018 in Denmark, 638 patients had Vibrio infections diagnosed and 521 Shewanella diagnosed. Most cases occurred years with high seawater temperatures. The substantial increase those infections, some causing septicemia, calls for clinical awareness mandatory notification policies.
In industrialized countries, the leading cause of bacterial gastroenteritis is Campylobacter jejuni. However, outbreaks are rarely reported, which may reflect limitations surveillance, for molecular typing not routinely performed. To determine frequency genetic clusters among patients and to find links concurrent isolates from poultry meat, broiler chickens, cattle, pigs, dogs, we performed whole-genome sequencing on 1,509 C. jejuni 774 735 food or animal sources in Denmark during 2015-2017....
Typhoidal and para-typhoidal Salmonella are major causes of bacteraemia in resource-limited countries. Diagnostic alternatives to laborious resource-demanding serotyping essential. Fourier transform infrared spectroscopy (FTIRS) is a rapidly developing simple bacterial typing technology. In this study, we assessed the discriminatory power FTIRS-based IR Biotyper (Bruker Daltonik GmbH, Bremen, Germany), for rapid reliable identification biochemically confirmed typhoid paratyphoid...
To identify risk factors for Clostridium difficile infection (CDI) in Danish patients consulting general practice with gastrointestinal symptoms, a prospective matched case-control study was performed; cases (N = 259) had positive cultures toxigenic C. and controls 455) negative cultures. Data were analysed by conditional logistic regression. In aged ⩾2 years (138 cases), hospitalization [odds ratio (OR) 8·4, 95% confidence interval (CI) 3·1-23], consumption of beef (OR 5·5, CI 2·0-15),...
Information is sparse regarding the association between international travel and hospitalization with non-typhoidal Salmonella bacteremia. The aim of this study was to determine proportion, risk factors outcomes travel-related We conducted a 10-year population-based cohort all patients hospitalized bacteremia in three Danish counties (population 1.6 million). used denominator data on travellers assess per 100,000 according age destination. contemporaneously diagnosed gastroenteritis as...
Clostridium celatum [ce.la'tum. L. adj. hidden] has been known since 1974, when it was isolated from human feces. In 40 years, no association with infection reported. this work, we present two serious cases of the anaerobic Gram-positive rod celatum.
ABSTRACT Danish isolates of Shewanella algae constituted by whole-cell protein profiling a very homogeneous group, and no clear distinction was seen between strains from the marine environment clinical origin. Although variation all observed ribotyping random amplified polymorphic DNA analysis, clonal relationship infective found. From several patients, clonally identical S. were reisolated up to 8 months after primary isolation, indicating that same strain may be able maintain infection.
Legionella bozemanae is a rare isolate in clinical specimens. We describe case of joint infection due to L. an immunocompromised patient with dermatomyositis. Without the use PCR screening or culture on specialized medium, organism would not have been detected.
Background Only a subset of enteric pathogens is under surveillance in Denmark, and knowledge on the remaining detected acute gastroenteritis limited. Here, we present one-year incidence all diagnosed high-income country, 2018 an overview diagnostic methods used for detection.Methods All 10 departments clinical microbiology completed questionnaire test provided 2018-data persons with positive stool samples Salmonella species, Campylobacter jejuni/coli, Yersinia enterocolitica, Aeromonas...