A5068444829- Parasitic Infections and Diagnostics
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Parasites and Host Interactions
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Amoebic Infections and Treatments
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Travel-related health issues
- Burkholderia infections and melioidosis
- Vibrio bacteria research studies
- Vector-borne infectious diseases
- Malaria Research and Control
- Mosquito-borne diseases and control
- Mycobacterium research and diagnosis
- Infective Endocarditis Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV/AIDS Research and Interventions
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Viral Infections and Vectors
Bundeswehrkrankenhaus
2014-2025
University of Rostock
2009-2025
Institute of Medical Microbiology and Hygiene
2012-2024
Bernhard Nocht Institute for Tropical Medicine
2013-2022
Universitätsmedizin Rostock
2009-2021
GTx (United States)
2019
Armed Forces Hospital
2013
Friedrich-Loeffler-Institut
2013
RWTH Aachen University
2013
Universitätsklinikum Aachen
2013
Background The two major indications for tonsillectomy are recurrent tonsillitis (RT) and peritonsillar abscess (PTA). Unlike PTAs, which primarily treated surgically, RT is often cured by only after a series of failed drug therapy attempts. Although the bacteriological background has been studied, reason lack success conservative therapeutic approaches not well understood. Methods In prospective study, tonsil specimens from 130 patients 124 PTA were examined presence extra- intracellular...
Background: Molecular methods, in particular PCR, are increasingly used for the diagnosis of enteric pathogens stool samples. In high-endemicity settings, however, asymptomatic carriage or residual DNA from previous infections will hamper interpretation positive test results. We assessed quantitative dimension this problem schoolchildren rural highlands Madagascar. Methods: Stool samples were collected 410 apparently healthy Madagascan and analysed by multiplex real-time PCR enteroinvasive...
Due to the beginning of vaccination against COVID-19, serological discrimination between vaccine-associated humoral response and serology-based surveillance natural SARS-CoV-2 infections as well breakthrough becomes an issue relevance. Here, we assessed differentiated effects application RNA vaccine using spike protein epitopes on results both anti-spike protein–based serology (EUROIMMUN) anti-nucleocapsid-based (VIROTECH). A total 80 serum samples from vaccinees acquired at different time...
Swab-based nasal screening is commonly used to identify asymptomatic carriage of Staphylococcus aureus in patients. Bacterial detection depends on the uptake and release capacities swabs swabbing technique itself. This study investigates performance different swab-types MRSA-screening by utilizing a unique artificial nose model provide realistic standardized conditions.An anatomically correct was inoculated with numerically defined mixture MRSA epidermidis bacteria at quantities 4×10(2)...
Due to considerable differences in pathogenicity, Haemophilus influenzae, H. parainfluenzae and haemolyticus have be reliably discriminated routine diagnostics. Retrospective analyses suggest frequent misidentifications of commensal as influenzae. In a multi-center approach, we assessed the suitability fluorescence situ hybridization (FISH) matrix-assisted laser-desorption-ionization time-of-flight mass-spectrometry (MALDI-TOF-MS) for identification species level.A strain collection 84 spp....
Anthrax is an infectious disease of relevance for military forces. Although spores Bacillus anthracis obiquitously occur in soil, reports on soil-borne transmission to humans are scarce. In this narrative review, the potential anthrax discussed based pathogen-specific characteristics and course several centuries warfare. theory, foci can pose a risk infection animals if sufficient amounts virulent present soil even after extended period time. praxis, however, transmissions usually due...
At the Bundeswehr Hospitals of Hamburg and Westerstede, patients repatriated from subtropical war crisis zones Northern Africa Middle East were medically treated, including microbiological assessment. Within a six-year interval, 16 Acinetobacter spp. strains, 14 baumannii (Ab) isolates with resistance against carbapenems origins in Afghanistan (n = 4), Iraq 2), Libya Syria 8) collected. While clonal relationships Libyan Syrian strains had been assessed by superficial next generation...
Methicillin-resistant Staphylococcus aureus (MRSA) clones pose a significant threat to hospitalised patients because the bacteria can be transmitted by asymptomatic carriers within healthcare facilities. To date, nothing is known about prevalence of S. and MRSA among workers in Madagascar. The objective our study was examine clonal epidemiology nasal non-medical University students Antananarivo, This cross sectional screened swabs taken from for aureus. Multiplex PCR performed identify...
Introduction. Since 2013, European soldiers have been deployed on the Union Training Mission (EUTM) in Mali. From beginning, diarrhea has among most "urgent" concerns. Diarrhea surveillance based deployable real-time PCR equipment was conducted between December 2013 and August 2014. Material Methods. In total, 53 stool samples were obtained from 51 with acute diarrhea. Multiplex panels comprised enteroinvasive bacteria, diarrhea-associated Escherichia coli (EPEC, ETEC, EAEC, EIEC),...
Non-typhoidal Salmonella (NTS) cause the majority of bloodstream infections in Ghana, however mode transmission and source invasive NTS Africa are poorly understood. This study compares from water sources rural Ghana. Blood hospitalised, febrile children samples drinking were analysed for spp. Strains serotyped to trace possible epidemiological links between human water-derived isolates.. Antibiotic susceptibility testing was performed, In 2720 blood culture samples, 165 (6%) isolated. S....
Recently, a total of 32 carbapenem- and fluoroquinolone-resistant Acinetobacter baumannii (Ab) isolates was isolated from war-injured patients who were treated at German Bundeswehr Hospitals, preliminarily typed by "DiversiLab" repetitive elements sequence-based (rep-) PCR. Core genome-based sequence typing also used to provide more detailed epidemiological information. From the clusters observed rep-PCR, selected Ab strains subjected Next Generation Sequencing (NGS) in order compare them...
We evaluated a one-tube multiplex real-time PCR targeting DNA of Schistosoma haematobium complex and S. mansoni in serum samples obtained at different German diagnostic centers.Simplex protocols for the detection multi-copy DNA-repeats Dra1 Sm1-7 were combined to new format. The was subjected full validation including evaluation real-life setting with travelers migrants. results compared those stool urine microscopy, serology, circulating cathodic antigen (CCA) rapid tests urine. Sensitivity...
This study was performed as a head-to-head comparison of the performance characteristics (1) two SARS-CoV-2-specific rapid antigen assays with real-time PCR gold standard well (2) fully automated high-throughput transcription-mediated amplification (TMA) assay and in latent class analysis-based test without several hundred samples low prevalence "real world" setting. Recorded sensitivity specificity NADAL LumiraDx Hologic Aptima SARS-CoV-2 TMA were 0.1429 (0.0194, 0.5835), 0.7644 (0.7016,...
Abstract Pathogenic strains of Escherichia coli can cause gastrointestinal infections, urinary tract infections (UTIs), bacteremia, and other severe infections. Some isolates this species are capable producing extended-spectrum β-lactamase (ESBL) enzymes, which mediate resistance against penicillin derivates cephalosporins. Fungi the Ascomycota phylum known to produce antibiotics from different classes with activity various bacterial agents. Among them, genera Penicillium, Cephalosporium,...