A5103207780- Diphtheria, Corynebacterium, and Tetanus
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- Microbial infections and disease research
- Veterinary medicine and infectious diseases
- Botulinum Toxin and Related Neurological Disorders
- Neural and Behavioral Psychology Studies
- Toxin Mechanisms and Immunotoxins
- Streptococcal Infections and Treatments
- Plant and fungal interactions
- Rabies epidemiology and control
- Neural dynamics and brain function
- Autoimmune and Inflammatory Disorders
- Bacterial Infections and Vaccines
- Poxvirus research and outbreaks
- Salmonella and Campylobacter epidemiology
- EEG and Brain-Computer Interfaces
- Ecology and biodiversity studies
- Listeria monocytogenes in Food Safety
- Diverse Scientific and Economic Studies
- Bacillus and Francisella bacterial research
- COVID-19 epidemiological studies
- Sports Performance and Training
- Leptospirosis research and findings
Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit
2013-2025
Institute of Bioinformatics and Systems Biology
2020-2025
Health and Safety Authority
2020-2024
Universidade do Estado do Rio de Janeiro
2023
Ghent University
2021
Chemisches und Veterinäruntersuchungsamt Stuttgart
2021
Research Institute for Nature and Forest
2021
University of Regensburg
2018-2020
Institute of Medical Microbiology and Hygiene
2019-2020
University of Cologne
2020
Diphtheria toxin (DT) is produced by toxigenic strains of the human pathogen Corynebacterium diphtheriae as well zoonotic C. ulcerans and pseudotuberculosis. Toxigenic may cause severe respiratory diphtheria, myocarditis, neurological damage or cutaneous diphtheria. The DT encoding tox gene located in a mobile genomic region variability between has been postulated based on sequences few isolates. In contrast, species-specific sequence analysis diphtheria repressor (dtxR), occurring both...
After 3 cases of Corynebacterium diphtheriae infection associated with intravenous drug use among persons experiencing homelessness (PEH) were reported to the Health Protection Authority in Frankfurt am Main, Germany, 2023, we examined pathogen spread PEH. Furthermore, investigated a possible link 2022 outbreak diphtheria Europe. From swab samples collected during August-November 2023 from 36 PEH and cutaneous lesions, detected additional toxigenic C. diphtheriae. Sequence type 574 was...
The rapid identification of the potentially toxigenic Corynebacterium species, C. diphtheriae, ulcerans and pseudotuberculosis is essential for diagnosis treatment diphtheria diphtheria-like diseases. We used matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) in comparison with classical microbiological molecular methods on 116 strains. All 90 strains collected by German National Consiliary Laboratory Diphtheria a period more than ten years were...
Toxigenic Corynebacterium diphtheriae is an important and potentially fatal threat to patients public health. During the current dramatic influx of refugees into Europe, our objective was use whole genome sequencing for characterization a suspected outbreak C. wound infections among refugees. After conventional culture, we identified using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) investigated toxigenicity by PCR. Whole performed on MiSeq Illumina with...
From July 2022, cases of imported diphtheria with toxigenic Corynebacterium diphtheriae remarkably increased among migrants arriving in Germany. Up to 30 September 44 have been reported the national public health institute, all laboratory-confirmed, male, and mainly coming from Syria (n = 21) Afghanistan 17). Phylogeny available journey information indicate that most 19) were infected along Balkan route. Active case finding, laboratory preparedness epicentre localisation countries this route...
From 2016 through the middle of 2017, German Consiliary Laboratory on Diphtheria noted an increase in nontoxigenic Corynebacterium diphtheriae isolates submitted from cities northern Germany. Many patients for whom epidemiologic data were available homeless, alcohol or drug abusers, both. After performing routine diagnostics and multilocus sequence typing (MLST), we analyzed type (ST) 8 previously by whole-genome sequencing. Results phylogenetic relationship core genome MLST (cg-MLST)...
A total of 34 Corynebacterium sp. strains were isolated from caseous lymph node abscesses wild boar and roe deer in different regions Germany. They showed slow growth on Columbia sheep blood agar sparse Hoyle's tellurite agar. Cellular fatty acid analysis allocated them the C. diphtheriae group genus Corynebacterium. MALDI-TOF MS using specific database extensions rpoB sequencing resulted classification as ulcerans. Their quinone system is similar to ulcerans, with major menaquinone...
Due to considerable differences in pathogenicity, Haemophilus influenzae, H. parainfluenzae and haemolyticus have be reliably discriminated routine diagnostics. Retrospective analyses suggest frequent misidentifications of commensal as influenzae. In a multi-center approach, we assessed the suitability fluorescence situ hybridization (FISH) matrix-assisted laser-desorption-ionization time-of-flight mass-spectrometry (MALDI-TOF-MS) for identification species level.A strain collection 84 spp....
Diphtheria is mainly caused by diphtheria-toxin-producing strains of Corynebacterium diphtheriae and ulcerans. The recommended first-line antibiotic penicillin or erythromycin, but reliable susceptibility data are scarce.To define WT MIC distributions 12 antimicrobial agents provide for the determination tentative epidemiological cut-off values (TECOFFs) potentially toxigenic corynebacteria to evaluate potential usefulness a gradient test (Etest) testing penicillin, erythromycin...
Abstract Background Evidence-based clinical susceptibility breakpoints have been lacking for antimicrobial agents used diphtheria. Objectives We aimed to evaluate broth microdilution and disc diffusion methods create a dataset of MIC values inhibition zone diameters (ZDs) from which could be determined. Methods included 400 recent isolates equally distributed by species (Corynebacterium diphtheriae Corynebacterium ulcerans) national surveillance programmes (France Germany). Non-duplicate...
Severe necrotizing fasciitis was diagnosed in a 53-year-old man Germany 2012. Toxigenic Corynebacterium ulcerans grown from wound swab sample. One of the patient's 2 dogs found to harbor toxigenic C. strain. Results next generation sequencing both isolates supported recent zoonotic transmission this bacterial pathogen.
Toxigenic Corynebacterium ulcerans may cause both respiratory and cutaneous diphtheria in humans. As a zoonotic emerging pathogen it has been isolated from wide variety of animals living captivity, such as livestock, pet, zoo research additionally large number different wild animals. Here we report the isolation tox-positive C. four hedgehogs with pneumonia, respectively.
Background and aim As a consequence of socioeconomic political crises in many parts the world, European Union/European Economic Area (EU/EEA) countries have faced an increasing number migrants. In German federal state Bavaria, mandatory health screening approach is implemented, where individuals applying for asylum to undergo medical examination that includes serological testing HIV hepatitis B, tuberculosis, until September 2015, stool Salmonella spp. Shigella spp.. Methods : Data from all...
In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child's sibling superinfected insect bites harbouring also C. diphtheriae. Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that two cases constitute first outbreak since 1980s.
Abstract Cognitive control is the ability to monitor, evaluate, and adapt behavior in service of long‐term goals. Recent theories have proposed that integral negative emotions elicited by conflict are critical for adaptive adjustment cognitive control. However, evidence valence tasks mainly comes from behavioral studies interrupted trial sequences, making it difficult directly test link between conflict‐induced affect subsequent increases In present study, we therefore use online measures...
Background In 2017, a food-borne Salmonella Agona outbreak caused by infant milk products from French supplier occurred in Europe. Simultaneously, S. was detected animal feed samples Bavaria. Aim Using next generation sequencing (NGS) and three data analysis methods, this study’s objectives were to verify clonality of the Bavarian strains, rule out their connection outbreak, explore genetic diversity isolates 1993 2018 compare approaches employed, for practicality ability delineate outbreaks...