A5017404357- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Microscopic Colitis
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- COVID-19 diagnosis using AI
- Dental Research and COVID-19
- Diphtheria, Corynebacterium, and Tetanus
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Oral microbiology and periodontitis research
- Diverticular Disease and Complications
- Microbial infections and disease research
- Infections and bacterial resistance
- Vibrio bacteria research studies
- Enterobacteriaceae and Cronobacter Research
- Antifungal resistance and susceptibility
- Bacillus and Francisella bacterial research
- Rabies epidemiology and control
- Fungal Infections and Studies
Copenhagen University Hospital
2021-2024
Amager Hospital
2022-2024
Hvidovre Hospital
2013-2023
University of Copenhagen
2023
Slagelse Hospital
2015-2017
Statens Serum Institut
2009-2013
Roskilde University
2013
ABSTRACT The prevalence of intrinsic and acquired resistance among colonizing Candida isolates from patients after candidemia was investigated systematically in a 1-year nationwide study. Patients were treated at the discretion treating physician. Oral swabs obtained treatment. Species distributions MIC data for blood posttreatment oral exposed to either azoles or echinocandins <7 ≥7 days. identification confirmed using matrix-assisted laser desorption ionization–time flight mass...
This study aimed to characterise carbapenemase-producing Acinetobacter baumannii (A. baumannii) isolates from Danish patients using whole genome sequencing (WGS). It also compared typing and epidemiological data for further investigation of the spread origin A. isolates. From 1 January 2014 30 September 2021, 141 isolates, received at national reference laboratory Statens Serum Institut, were investigated WGS. Multilocus sequence (MLST) cgMLST data, obtained by SeqSphere+ software, linked...
Primary screening for VRE with PCR directed against vanA allowed identification of vanA+ samples from which could not be isolated when selective culture methods were used. From such a sample vancomycin-susceptible, Enterococcus faecium, Efm-V1511, was isolated, vancomycin selection used during culture. Similar isolates variable susceptibility to obtained in the following months.To characterize Efm-V1511 and investigate causes vancomycin.All strains sequenced using Illumina technology....
Background Carbapenemase-producing Escherichia coli are increasing worldwide. In recent years, an increase in OXA-244-producing E. isolates has been seen the national surveillance of carbapenemase-producing organisms Denmark. Aim Molecular characterisation and epidemiological investigation from January 2016 to August 2019. Methods For investigation, data Danish National Patient Registry register civil registration were used together with phone interviews patients. Isolates characterised by...
To identify risk factors for Clostridium difficile infection (CDI) in Danish patients consulting general practice with gastrointestinal symptoms, a prospective matched case-control study was performed; cases (N = 259) had positive cultures toxigenic C. and controls 455) negative cultures. Data were analysed by conditional logistic regression. In aged ⩾2 years (138 cases), hospitalization [odds ratio (OR) 8·4, 95% confidence interval (CI) 3·1-23], consumption of beef (OR 5·5, CI 2·0-15),...
ABSTRACT The diversity of OXA-48-like carbapenemases is continually expanding. In this study, we describe the dissemination and characteristics a novel carbapenem-hydrolyzing class D β-lactamase (CHDL) named OXA-436. total, six OXA-436-producing Enterobacteriaceae isolates, including Enterobacter asburiae ( n = 3), Citrobacter freundii 2), Klebsiella pneumoniae 1), were identified in four patients period between September 2013 April 2015. All three species found one patient. amino acid...
Increasing rates of Clostridium difficile infection (CDI) with an unusual, severe course have been reported in several countries; this rise has partly ascribed to the emergence a virulent strain, C. PCR ribotype 027 (CD027). An intriguing question is whether could be related increasing consumption broadspectrum antibiotics. From 1997 2007, number hospital discharges Denmark diagnosis enterocolitis caused by increased from eight 23 per 100,000 discharges. This increase was proportional...
Anthrax had become extremely rare in Europe, but 2010 an outbreak of anthrax among heroin users Scotland increased awareness contaminated as a source anthrax. We present the first two Danish cases injectional and discuss clinical presentations, which included both typical more unusual manifestations. The patient, 55-year old man with HIV hepatitis C virus co-infection, presented severe pain right thigh lower abdomen after injecting into groin. Computed tomography ultrasonographic examination...
Chorioamnionitis is a potentially life threatening infection of the fetal membranes, commonly caused by ascending bacteria from vagina and cervix. In our case, healthy nullipara with term pregnancy presented clinical signs after induced labour an intracervical balloon. Thick green foul smelling amniotic fluid was observed culture showed massive growth Aerococcus christensenii, facultative anaerob species found in human vagina, previously only rarely alleged to cause invasive infection....
We investigated whether prior use of antibiotics affects the risk mecillinam/trimethoprim/nitrofurantoin/multi-resistant Escherichia coli urinary tract infection (UTI) among elderly patients in general practice. Data on urine culture came from samples performed practice and sent to hospitals Capital Region Denmark, prescription data a nationwide database. The study population consisted with UTI episodes (n = 41,027) caused by E. that received concurrent antibiotic against 2012 2017. used...
From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient Iceland. There no nosocomial links between patients, but they had all been treated dicloxacillin capsules. An E. ST79, identical to isolates, was cultured from the surface of capsules Denmark, strongly implicating them as source outbreak. Special attention is required detect outbreak strain microbiology laboratory.
Bacteroides fragilis group species are the most frequently encountered bacteria involved in anaerobic bacteraemia and associated with high mortality rates. In 2012, we performed first national study of antimicrobial susceptibility B. from blood cultures Denmark.
Syndromic testing for lower respiratory tract infections with BioFire® FilmArray® Pneumonia Panel Plus (BF) detects 27 pathogens a turn-around-time of one hour. We compared the performance BF culture. Samples from 298 hospitalized patients suspected pneumonia routinely sent culture were also analyzed using BF. Retrospectively, clinically categorized as having "pneumonia" or "no pneumonia." and by analytical performance, which was evaluated pathogen concordance, clinical comparing detections...
It is important to identify children and adolescents infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as they are often asymptomatic may unintentionally spread the virus. However, information on best sampling methods limited. Most tests analyse nose throat swabs real-time polymerase chain reaction (RT-PCR), but these uncomfortable, young not co-operate, increasing suboptimal sample collection false-negative results. Detecting SARS-CoV-2 in adult saliva, using...
To the Editors: Less than 1% of pediatric Salmonella infections present with osteomyelitis often associated to hemoglobinopathies, yet extraordinary in immunocompetent children.1,2 Despite relevant antibiotic therapy, treatment is prolonged and duration without international consensus. We report a case (SOM) an 10-month-old girl. A previously healthy girl was admitted ward due persistent fever being unable crawl. Physical examination revealed (38.1°C), erythema, swelling, pain, dysfunction...
We aimed to identify specific anaerobic bacteria causing bacteraemia and a subsequent diagnosis of colorectal cancer.