A5101567037- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Global Maternal and Child Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic aneurysm repair treatments
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Building materials and conservation
- Pharmacovigilance and Adverse Drug Reactions
- Medication Adherence and Compliance
- Parasites and Host Interactions
- Thyroid Disorders and Treatments
- Stoma care and complications
- Vibrio bacteria research studies
- Parasite Biology and Host Interactions
- High Altitude and Hypoxia
- Viral gastroenteritis research and epidemiology
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
- Maternal and fetal healthcare
Aalborg University
2018-2024
Aalborg University Hospital
2018-2024
Skive Hospital
2023
University of Copenhagen
2021
Rockwool Foundation
2021
Rigshospitalet
2021
Thrombosis Research Institute
2020
Jensen Hughes (United States)
2020
Paris Cardiovascular Research Center
2019
Inserm
2019
Background It is unclear whether nonvitamin K antagonist oral anticoagulants ( NOAC s) can mitigate dementia development in atrial fibrillation. We compared among users of NOACs or warfarin patients with fibrillation no prior neurological diagnoses. Methods and Results conducted a Danish nationwide cohort study including 33 617 new anticoagulant nonvalvular fibrillation, which 11 052 were aged 60 to 69 years, 13 237 70 79 9238 80 years older. To exclude prevalent non -oral anticoagulants-...
Abstract Aims Patient-reported outcome measures (PROMs) may predict poor clinical in patients with heart failure (HF). It remains unclear whether PROMs are associated subsequent adherence to HF medication. We aimed determine health-related quality of life, anxiety, and depression were long-term medication these patients. Methods results A national cohort study Danish 3-year follow-up (n = 1464). included the EuroQol five-dimensional, five-level questionnaire (EQ-5D-5L), HeartQoL Hospital...
Frail people with atrial fibrillation are often undertreated oral anticoagulants (OACs), and evidence for the net clinical benefit (NCB) of OAC is sparse. We, therefore, examined risk thromboembolic events, major bleeding, NCB anticoagulation treatment.
Abstract Purpose To analyze the nationwide incidence of Salmonella infections in Denmark from 2013 to 2022. Methods Confirmed cases enterica subsp. were examined using National Register Enteric Pathogens during 2013–2022. Proportions, rates (IR), relative risk (RR), and 95% confidence intervals (CI) calculated assess differences serotypes, invasiveness, age, sex, travel exposure. Results We identified 9,944 Danish cases, with an average annual rate 16.9 per 100,000 inhabitants, declining...
Substantial interest has been directed towards stroke risk stratification in patients with atrial fibrillation (AF) but prior studies have focused on AF without significant valvular heart disease (VHD), so-called 'non-valvular AF'. A formal validation exercise addressing risks relation to the CHA2DS2-VASc factor(s) VHD is lacking. Also, use of HAS-BLED score anticoagulated not previously studied. The aim this study was investigate and bleeding rates scores. We conducted a nationwide cohort...
Background Single-dose praziquantel (PZQ) for treating urogenital schistosomiasis has been reported as inadequate achieving significant resolution of female genital (FGS)-associated cervicovaginal lesions. This randomised controlled trial aimed to assess the efficacy and safety a repeated PZQ-dosing regimen. Methods The was conducted among women aged 15 34 with FGS-associated cervical lesions living in Schistosoma haematobium -endemic area northern Madagascar. A total 116 were randomly...
Uncertainty remains about the most appropriate timing of induction labor in late-term pregnancies. To address this issue, study aimed to compare risk neonatal morbidity and pregnancy- birth-related complications between gestational age (GA) 41+4 -42+0 GA 41+0 -41+3 weeks.This nationwide registry-based cohort included singleton births without major congenital malformations, with registered GA, intended vaginal delivery at - 42+0 weeks 2009 2018 Denmark. Logistic regression models were used...
To evaluate the effects of an outpatient clinic setup for minor stroke/TIA using subsequent admission patients at high risk recurrent stroke.We performed a cohort study all with suspected seen in Aarhus University Hospital, Denmark, between September 2013 and August 2014. Patients stroke were compared to historic (same hospital) contemporary (another comparable matched, hospitalized controls on nonprioritized outcomes: length stay, readmissions, care quality (10 process-performance...
To describe the risks of thromboembolism and major bleeding complications in anticoagulated patients with atrial fibrillation (AF) native aortic or mitral valvular heart disease using data reflecting clinical practice.Descriptive cohort study incident AF disease, identified nationwide Danish registries from 2000 to 2018. A total 10 043 were included, which 5190 (51.7%) had stenosis, 1788 (17.8%) regurgitation, 327 (3.3%) 2738 (27.3%) regurgitation. At 1 year after diagnosis, risk was 4.6%...
Abstract Aims An in-depth understanding of the prognostic value patient-reported outcomes (PRO) is essential to facilitate person-centred care in heart failure (HF). This study aimed clarify role subjective mental and physical health status patients with HF. Methods results Patients HF were identified from DenHeart Survey (n = 1499) PRO data obtained at hospital discharge, including EuroQol five-dimensional questionnaire (EQ-5D), HeartQoL, Hospital Anxiety Depression Scale (HADS). Clinical...
Aims The risks of thromboembolism and bleeding in patients with atrial fibrillation (AF) valvular heart disease (VHD) are sparsely described. We described the risk events non-anticoagulated anticoagulated AF VHD according to evaluated valves, rheumatic or artificial valve classification (EHRA classification), EHRA Type 1 2 VHD, within subgroups VHD. Methods Results Cohort study coexisting identified nationwide Danish registries from 2000 2018. Risk after year follow-up were calculated each...
Background and purpose The effectiveness safety of edoxaban 60 mg 30 for stroke prevention compared with warfarin in patients atrial fibrillation have not been well-described a nationwide cohort Caucasian treated standard clinical practice. Methods We used Danish registries to identify during June 2016 November 2018 who were or computed rates per 100 person-years thromboembolic, all-cause mortality, bleeding events using an inverse probability treatment weighting approach account baseline...
Background Guideline recommendations on the use of non–vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with aortic stenosis are based studies including a low number stenosis. The aim this study was to estimate effects NOAC versus warfarin thromboembolism and major bleeding among AF Methods Results We emulated target trial using observational data from Danish nationwide registries between 2013 2018. Thromboembolism defined as hospital diagnosis ischemic...
In patients with intracerebral hemorrhage (ICH) and prevalent atrial fibrillation (AF), the optimal stroke prevention strategy is unclear. We sought to estimate risk of cerebrovascular events among ICH survivors AF.
This study sought to describe the risk of thromboembolism in nonanticoagulated atrial fibrillation patients with Evaluated Heartvalves, Rheumatic or Artificial (EHRA) Type 2 valvular heart disease (VHD) <65 65 74 years age and 0 1 non-sex comorbidity CHA2DS2-VASc score. A minor, but important, proportion VHD beyond moderate-to-severe mitral stenosis and/or a mechanical prosthetic valve, so-called EHRA VHD, have coexisting comorbidities score, are therefore not strongly recommended oral...
Abstract European guidelines for heart failure (HF) have continuously incorporated new evidence since the first publication in 1995. We aimed to explore time trends utilisation of pharmacological treatment HF and dispensing recommended dosages among patients with a first‐time diagnosis HF. performed historical cohort study from 1997 2015, identified Danish National Patient Registry. Dispensed included angiotensin‐converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs),...
Abstract Given high recurrence risk after venous thromboembolism (VTE), guidelines recommend extended dose rivaroxaban (10 mg OD) or apixaban (2.5 BID) to be considered 6 months of initial treatment. This study aimed provide insight into clinical practice regarding the use preventive treatment and describe duration Linkage nationwide health registers identified all in‐ outpatients with VTE from April 2017 through 2018. Hazard ratios (HR) 95% confidence intervals (CIs) were calculated...
Background: Thyroid hormones and sympathetic stimulation are needed for activating Brown adipose tissue (BAT) during cold exposure. Studies of human exposure have demonstrated both increased production raised clearance triiodothyronine (T3). Greenlandic hunters provide a unique model evaluating metabolic effects Aim: We aimed to explore the dynamics thyroid when blocking activity in winter inspire knowledge on mechanisms BAT activation. Methods: conducted 7-day field study (n=7) East...
Atrial fibrillation (AF) is associated with an increased risk of stroke and the combination AF mitral stenosis (MS) a higher risk. In developed nations, degenerative (DMS) constitutes sizeable proportion patients MS. Current international guidelines do not offer recommendations regarding anticoagulation in these patients. The objective this study was to describe incidence or systemic embolism DMS without prevalent AF.
Abstract Background Atrial fibrillation (AF) and valvular heart disease (VHD) often coexist. They are independent causes of mortality morbidity, both have been associated with risk thromboembolic events. Historically, the definition VHD in AF patients has inconsistent, which led to proposal a new classification VHD: “Evaluated Heartvalves, Rheumatic or Artificial” (EHRA) valve classification, categorizing into: EHRA Type 1 2 VHD. comprises mitral stenosis (moderate-severe, rheumatic origin)...
Abstract Study question Can supplementation with additional rectal administration of progesterone secure high ongoing pregnancy rates (OPR) in patients low serum (P4) at blastocyst transfer (ET)? Summary answer Rectally administered starting on the day secures OPR P4 levels lower than 35 nmol/l (11ng/ml). What is known already Low peri-implantation HRT-FET cycles impact reproductive outcomes negatively. However, studies have shown that after a standard vaginal treatment can obtain live birth...
Abstract Background Frail patients with atrial fibrillation (AF) are often undertreated oral anticoagulants (OAC), and evidence for the net clinical benefit of OAC is sparse. Objectives We examined risk thromboembolic events major bleeding, association between age, frailty level, (NCB) anticoagulation. Methods This was an observational cohort study based on Danish nationwide data. aged ≥50 years a Hospital Frailty Risk Score ≥5 incident AF were identified from 2013-2018. Patients categorized...