A5015594299- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Vitamin D Research Studies
- Hip and Femur Fractures
- Diabetes Management and Research
- Connective tissue disorders research
- Diabetes Treatment and Management
- Parathyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Thyroid Disorders and Treatments
- Bone and Dental Protein Studies
- Diet and metabolism studies
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Bone and Joint Diseases
- Wnt/β-catenin signaling in development and cancer
- Cardiac Imaging and Diagnostics
- Growth Hormone and Insulin-like Growth Factors
- Coronary Interventions and Diagnostics
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Folate and B Vitamins Research
- Blood Pressure and Hypertension Studies
Hospital South West Jutland
2012-2024
University of Southern Denmark
2003-2021
Odense University Hospital
1996-2019
Endokrinologikum
2019
Aarhus University Hospital
2017
Regional Health
2016
County Hospital
2007
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To estimate the incidence of nutritional rickets and prevalence hereditary rickets.Population-based retrospective cohort study based on a review medical records.Patients aged 0-14.9 years referred to or discharged from hospitals in southern Denmark 1985 2005 with diagnosis were identified by register search, their records retrieved. Patients fulfilling diagnostic criteria primary included.We 112 patients whom 74% immigrants. From 1995 2005, average children 0-2.9 was 2.9 5.8 per 100,000 year...
The increased risk of cardiovascular morbidity and mortality associated with arterial hypertension is particularly pronounced in patients type 2 diabetes mellitus. Blood pressure control is, therefore, decisively important but often not sufficiently achieved.The primary objective this study was to evaluate the antihypertensive effect low dose spironolactone added triple therapy for resistant measured by ambulatory monitoring. Secondary objectives were effects on glycaemic urinary albumin...
Osteogenesis imperfecta (OI) is a hereditary, clinically heterogeneous, connective tissue disorder. The population prevalence of OI in Denmark 10.6 100,000. A hallmark the disease frequent fractures that are often precipitated by minimal trauma. aim current study was to compare fracture rates across lifespan patients with reference from general population. present Danish nationwide, population-based, cohort using register data. We identified 644 (55.6% females) through National Patient...
ABSTRACT Osteogenesis imperfecta (OI) is a hereditary connective tissue disease that causes frequent fractures. Little known about of death and length survival in OI. The objective this work was to calculate the risk cause death, median time patients with This study Danish nationwide, population-based register-based cohort study. We used National Patient Register data from 1977 until 2013 complete long-term follow-up. Participants comprised all registered diagnosis OI 2013, reference...
To assess the cardiovascular (CV) safety of oral semaglutide, first tablet formulation a glucagon-like peptide-1 receptor agonist.PIONEER 6 is multinational, randomized, placebo-controlled, double-blind trial in patients with type 2 diabetes at high risk CV events (defined as being aged ≥50 years and having established disease [CVD] or moderate [stage 3] chronic kidney [CKD], ≥60 ≥1 other factor). Patients were randomized to once-daily semaglutide (up 14 mg) placebo added standard care. The...
Purpose We investigated whether selenium supplementation improves quality-of-life (QoL) in patients with autoimmune thyroiditis (ID:NCT02013479). Methods included 412 ≥18 years serum thyroid peroxidase antibody (TPOAb) level ≥100 IU/mL a multicentre double-blinded randomised clinical trial. The were allocated 1:1 to daily either 200 μg as selenium-enriched yeast or matching placebo tablets for 12 months, add-on levothyroxine (LT4) treatment. QoL, assessed by the Thyroid-related...
Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease. To assess impact on mass and structure, we measured a real mineral density at the hip spine by dual-energy X-ray absorptiometry, volumetric BMD (vBMD) microarchitecture distal radius tibia high-resolution peripheral quantitative CT 25 morbidly obese subjects (15 females, 10 males) 0, 12 24 months after RYGB. Bone turnover markers (BTMs), calciotropic gut hormones...
Patients with chronic autoimmune thyroiditis have impaired health-related quality of life. The thyroid gland has a high selenium concentration, and specific selenoprotein enzyme families are crucial to immune function, catalyze hormone metabolism redox processes in cells. Previous randomized controlled trials found that supplementation decreases thyroid-disease-specific antibody levels. We hypothesize might be beneficial the treatment thyroiditis. CATALYST trial is an investigator-initiated...
Treatment effects of combining teriparatide and whole-body vibration exercise (WBV) vs alone in twelve months were compared using bone mineral density (BMD), microarchitecture, turnover markers. We found an increased effect lumbar spine BMD by adding WBV to postmenopausal osteoporotic women. The parathyroid hormone (PTH) analogue is effective but expensive anabolic treatment for osteoporosis. Whole-body has been stimulate muscle strength some studies. Animal data demonstrate a beneficial on...
Fracture risk is increased in individuals with type 2 diabetes (T2D). The pathophysiological mechanisms accentuating fracture T2D are convoluted, incorporating factors such as hyperglycaemia, insulinopenia, and antidiabetic drugs. objectives of this study were to assess whether different insulin regimens, metformin rosiglitazone influence bone metabolism. We explored if the concentration blood or improved glycaemic control altered turnover. Two-year clinical trial designed investigate...
Abstract The aim of this study was to the influence hormone replacement therapy (HRT) on weight changes, body composition, and bone mass in early postmenopausal women a partly randomized comprehensive cohort design. A total 2016 ages 45–58 years from 3 months 2 past last menstrual bleeding were included. One thousand randomly assigned HRT or no an open trial, whereas others allocated according their preferences. All followed for 5 weight, mass, composition measurements. Body increased less...
Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in degradation organic detail found that lysosomal acidification is this process MMPs are capable degrading absence cathepsin K.Osteoclasts resorb vacuolar H+-adenosine triphosphatase (V-ATPase) chloride channel ClC-7, followed matrix, mainly collagen type I, K possibly metalloproteinases (MMPs). However, switch from to proteolysis exact roles both ion transporters proteinases...
Both Nordic walking and Exercise on Prescription have potential as elements in the management of type 2 diabetes mellitus. These programs are recommended, but their effectiveness has not yet been established. The aim was to evaluate efficacy these interventions compared with standard information physical activity.Single-blinded, randomized, controlled intervention study.Sixty-eight patients (37 men 31 women) were randomized into 3 groups: (NW; n = 22), (EP; 24), control (CG; 22).: Patients...
Abstract Osteogenesis imperfecta (OI) is a hereditary disorder characterized by decreased biosynthesis or impaired morphology of type I collagen that leads to bone mass and increased fragility. We hypothesized patients with OI have altered microstructure geometry. In this cross-sectional study we compared age- gender-matched healthy controls. A total 39 (13 men 26 women) OI, aged 53 (range, 21–77) years, controls, were included in the study. Twenty-seven had been treated bisphosphonates....
Abstract Background Treatment of patients with perioxisome proliferator‐activated receptor‐γ full agonists are associated weight gain, heart failure, peripheral oedema, and bone loss. However, the safety partial has not been established in a clinical trial. The BAL aglitazone glucose L owering E fficacy T rial aimed to establish glucose‐lowering effects parameters agonist balaglitazone diabetic on stable insulin therapy. Methods Four hundred nine subjects from three countries type 2 diabetes...
Graves' hyperthyroidism is an autoimmune disease causing hyperfunction of the thyroid gland. The concentration selenium high in gland and two important groups enzymes within are selenoproteins, that is, they depend on selenium. Selenium may have beneficial effects hypothyroidism orbitopathy, but unknown. We hypothesize adjuvant be treatment hyperthyroidism. objective to investigate if supplementation plus standard with anti-thyroid drugs versus will lead a decrease drug failure (that remain...