A5088326019- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 and healthcare impacts
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Hemophilia Treatment and Research
- Eicosanoids and Hypertension Pharmacology
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Congenital Heart Disease Studies
- Cytokine Signaling Pathways and Interactions
- Sepsis Diagnosis and Treatment
- Diabetes and associated disorders
- Lymphoma Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Apelin-related biomedical research
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015-2024
University of Milan
2015-2024
Martin Luther University Halle-Wittenberg
2023
Lombardia Informatica (Italy)
2023
Ospedale Maggiore
2015-2023
University Hospital Bonn
2023
Hospital Universitari Germans Trias i Pujol
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2021
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2020
Universitat de Barcelona
2009-2020
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Most morbidity associated with syndrome related to vascular complications, in which endothelial dysfunction a major pathogenic factor. However, whether NAFLD within vasculature unknown. The aims this study were explore, model diet-induced overweight that expresses most features syndrome, early dysfunction. Wistar Kyoto rats fed cafeteria diet (CafD; 65% fat, mostly saturated) or control (CD) for 1...
<h3>Background and aims</h3> Endothelial dysfunction is a major determinant of the increased hepatic vascular tone cirrhotic livers. Von Willebrand factor (vWF), P-selectin 8-iso-PGF2α (isoprostanes), surrogate markers endothelial dysfunction, are in patients with cirrhosis. This study was aimed at exploring cirrhosis portal hypertension relation these factors systemic haemodynamics their possible clinical prognostic value. <h3>Methods</h3> 42 consecutive had measurement venous pressure...
Abstract The response to antiviral therapy is lower in hepatitis C virus (HCV) patients with genotype 1 than those 2. Overexpression of the suppressor cytokine signaling 3 (SOCS3) gene liver tissue associated a poorer treatment outcome chronic viral 1. Also, insulin resistance has been implicated nonresponse an anti-HCV treatment. To understand why HCV respond differently, we investigated SOCS3 expression, metabolic syndrome (MS), and cohort HCV-related hepatitis. A total 198 (108 90 2)...
Congenital extrahepatic portosystemic shunt (CEPS) or Abernethy malformation is a rare condition in which splanchnic venous blood bypasses the liver draining directly into systemic circulation through congenital shunt. Patients may develop hepatic encephalopathy (HE), pulmonary hypertension (PaHT), tumors, among other complications. However, actual incidence of such complications unknown, mainly because lack protocolized approach to these patients. This study characterizes clinical...
•Total cross-sectional SPSS area (TSA) predicts survival in patients with advanced chronic liver disease.•The cut-off for TSA that is associated worse corresponds to a single shunt of >10 mm diameter.•This study may impact on the clinical use TSA/SPSS risk stratification and decision-making management cirrhosis. Background & AimsSpontaneous portosystemic shunts (SPSS) frequently develop Recent data suggested presence large complications, especially overt hepatic encephalopathy (oHE)....
Endothelial dysfunction drives vascular derangement and organ failure associated with sepsis. However, the consequences of sepsis on liver sinusoidal endothelial function are largely unknown. Statins might improve microvascular in The present study explores abnormalities effects statins a rat model endotoxemia. For this purpose, lipopolysaccharide (LPS) or saline was given to: (1) rats treated placebo; (2) simvastatin (25 mg/kg, orally), at 3 23 hours after LPS/saline challenge; (3) mg/kg/24...
Hepatic venous pressure gradient (HVPG), the difference between wedge and free hepatic pressure, is preferred method for estimating portal pressure. However, it has been suggested that atrial (HAPG)—the right (RAP)—might better reflect variceal hemodynamics. The aim of this study was to (1) investigate whether HAPG with nonselective beta-blockers correlates prognosis in cirrhotic patients hypertension at baseline during treatment; (2) compare prognostic value HVPG; (3) agreement portoatrial...
Abstract Background & Aims Bacterial strains resistant to antibiotics are a serious clinical challenge. We assessed the antibiotic susceptibility of bacteria isolated from infections in patients with cirrhosis by multicentre investigation. Results Three hundred and thirteen culture‐positive (173 community acquired [ CA ] 140 hospital HA ]) were identified 308 patients. Urinary tract infections, spontaneous bacterial peritonitis bacteremias most frequent. Quinolone‐resistant Gram‐negative...
Portal vein thrombosis (PVT) is frequently observed in cirrhosis and may be a clinically important complication. In vitro assays for endogenous thrombin potential (ETP) demonstrated that plasma has intrinsic resistance to the anticoagulant action of thrombomodulin (TM-R). This study retrospectively explores association TM-R with de novo PVT its clinical impact on cirrhosis.Fifty-three patients were tested ETP-ratio with/without thrombomodulin. Clinical, endoscopic variables, presence/absence...
A hepatic venous pressure gradient (HVPG) decrease of 20% or more (or ≤12 mm Hg) indicates a good prognosis during propranolol/nadolol treatment but requires two HVPG measurements. We aimed to simplify the risk stratification after variceal bleeding using clinical data and HVPG.A total 193 patients with cirrhosis (62% ascites and/or encephalopathy [HE]) who were within 7 days had their measured before at 1-3 months plus endoscopic band ligation. The endpoints rebleeding...