A5087901718- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Silymarin and Mushroom Poisoning
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- SARS-CoV-2 and COVID-19 Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Kidney Injury Research
- Liver Diseases and Immunity
- Electrolyte and hormonal disorders
- Anesthesia and Sedative Agents
- Clinical Nutrition and Gastroenterology
- Poisoning and overdose treatments
- Eicosanoids and Hypertension Pharmacology
- Sepsis Diagnosis and Treatment
- Hepatitis C virus research
- Adrenal Hormones and Disorders
- Neonatal Health and Biochemistry
Hospital Clínic de Barcelona
2015-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2025
Universitat de Barcelona
2015-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013-2023
Hospital Universitario de La Princesa
2020
Hospital Universitari i Politècnic La Fe
2020
Complejo Hospitalario de Pontevedra
2020
Hospital Clínico Universitario de Valencia
2020
Centro de Investigación Biomédica en Red
2018
Spanish Society of Hematology and Hemotherapy
2012
Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk infection. This investigation evaluated prevalence and characteristics bacterial fungal infections causing complicating ACLF, predictors follow-up impact on survival. Patients 407 patients with ACLF 235 acute decompensation (AD). Results 152 (37%) presented at diagnosis; 46%(n=117) remaining 255 developed during (4 weeks). The corresponding figures in AD were 25% 18%...
BackgroundCoronavirus disease 2019 (COVID-19) is associated with a high burden 10% of confirmed cases progressing towards critical illness. Nevertheless, the course and predictors mortality in critically ill patients are poorly understood.MethodsFollowing developments ICUs regions experiencing early inception pandemic, European-based, international RIsk Stratification COVID-19 Intensive Care Unit (RISC-19-ICU) registry was created to provide near real-time assessment developing illness due...
•Factors related to more severe portal hypertension are associated with higher risk of PVT in cirrhosis.•Acquired and inherited alterations coagulation do not predict development during follow-up.•Cirrhosis-associated inflammation or generation NETs relevant factors predicting development. Background & AimsPortal vein thrombosis (PVT) is a relatively frequent event patients cirrhosis. While different for have been reported, such as decreased blood flow velocity (PBFV) parameters severity...
<h3>Background and aims</h3> Endothelial dysfunction is a major determinant of the increased hepatic vascular tone cirrhotic livers. Von Willebrand factor (vWF), P-selectin 8-iso-PGF2α (isoprostanes), surrogate markers endothelial dysfunction, are in patients with cirrhosis. This study was aimed at exploring cirrhosis portal hypertension relation these factors systemic haemodynamics their possible clinical prognostic value. <h3>Methods</h3> 42 consecutive had measurement venous pressure...
Balanced hemostasis with hypocoagulable and hypercoagulable features may occur in acute‐on‐chronic liver failure (ACLF). The characteristics prognostic impact of the coagulation profile ACLF are unknown. Consecutive patients (n = 36) acute decompensation (AD; n 24) were included. Blood samples for thromboelastometry (TE) obtained at admission 72 hours thereafter. was evaluated without those systemic inflammatory response syndrome. on transfusion requirements, bleeding events, short‐term...
It remains unclear whether rectal colonization with multidrug-resistant organisms (MDROs) is prevalent and predisposes to infections by the same pathogens in patients cirrhosis.Two series of critically ill were evaluated. In Barcelona cohort, 486 consecutive prospectively evaluated, 129 357 without cirrhosis (2015-2016). Rectal swabs performed at admission weekly thereafter (until intensive care unit [ICU] discharge) detect MDRO colonization. Risk factors for infection MDROs A retrospective...
Cirrhosis is the final stage of most chronic liver diseases, and almost invariably complicated by portal hypertension, which important cause morbidity mortality in these patients. This review will focus on non-invasive methods currently used clinical practice for diagnosing cirrhosis hypertension. The first-line techniques include physical examination, laboratory parameters, transient elastography Doppler-US. More sophisticated imaging are less commonly employed CT scan MRI, new technologies...
Measurement of the hepatic venous pressure gradient (HVPG) offers valuable prognostic information in patients with cirrhosis. In specific circumstances, (children, agitated patients, TIPS placement) deep sedation is required. This study aims to assess impact on accuracy hepatic/portal measurements.Forty-four were included. Measurements baseline HVPG (n = 30), response i.v. propranolol 11), portal (PPG) after 27) and cardio-pulmonary pressures 25) obtained awake conditions under propofol...
•Around 9% of patients with alcohol-related cirrhosis are delisted for improvement.•MELD score is the main determinant improvement.•Women have higher probabilities being improvement.•Outcomes after delisting globally favorable and affected by alcohol relapse. Background & AimsTo what extent decompensated can improve until recovery from decompensation remains unclear. We aimed to investigate probability due improvement in on waiting list (WL) liver transplantation (LT).MethodsWe conducted a...
Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal circulating mediators, be used as rescue therapy in these patients.Single center case series.Local study.Four critically ill adults with coronavirus disease 19 pneumonia that failed conventional interventions.Plasma exchange. Two six sessions (1.2 volumes). Human albumin (5%) main...
Noninvasive identification of significant portal hypertension in patients with cirrhosis is needed hepatology practice.To investigate whether the combination sCD163 as a hepatic inflammation marker and fibrosis markers Enhanced Liver Fibrosis score (ELF) can predict cirrhosis.We measured ELF components (hyaluronic acid, tissue inhibitor metalloproteinase-1 procollagen-III aminopeptide) two separate cohorts that underwent vein catheterisation. To test predictive accuracy we developed...
Porto-sinusoidal vascular liver disorder (PSVD) is a rare disease that occasionally requires transplantation (LT), despite usually presenting preserved function. There remains paucity of data pertaining to LT in PSVD. The aim was identify features associated with post-LT outcomes PSVD.Retrospective multicentre study 79 patients who received for PSVD.Median follow-up 37 (range 1-261) mo. Refractory ascites 24 (30%), hepatic encephalopathy 16 (20%), and hepatopulmonary syndrome 13 (16.3%) were...
Cholemic nephropathy is an overlooked cause of acute kidney injury (AKI) in patients with advanced cirrhosis and high bilirubin plasma levels (usually above 20mg/dl), due to bile acid deposition the kidneys. Those deposits have been hypothesized tubular injury. It has no standardized diagnostic criteria or therapeutic strategies. We present a series fifteen severe cholemic AKI, diagnosed by microscopic urinary cast visualization after excluding treating other causes AKI. Bilirubin removal...
Idiopathic portal hypertension (IPH) is a rare cause of that lacks specific diagnostic test. Requiring ruling-out other causes it frequently misdiagnosed. This study evaluates whether using high-throughput techniques there metabolomic profile allowing noninvasive diagnosis IPH.Thirty-three IPH patients were included. Matched with cirrhosis (CH) and healthy volunteers (HV) included as controls. Metabolomic analysis plasma samples was performed UPLC-time-of-flight-mass spectrometry. We...
OBJECTIVES: Tetrahydrobiopterin (BH4), a cofactor of nitric oxide synthase, might have role in the treatment portal hypertension (PHT) as its administration improves endothelial generation and hepatic dysfunction, reduces pressure experimental models cirrhosis. Sapropterin is an oral synthetic analogue BH4 recently approved for phenylketonuria. This study evaluated safety effects sapropterin on systemic hemodynamics patients with cirrhosis PHT. METHODS: Forty PHT (hepatic venous gradient...