A5046199922- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiopharmaceutical Chemistry and Applications
- Hepatitis B Virus Studies
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Infant Nutrition and Health
- Cardiac Arrest and Resuscitation
- Galectins and Cancer Biology
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Digestive system and related health
- Mechanical Circulatory Support Devices
- Animal Genetics and Reproduction
- Nutrition and Health in Aging
- Amoebic Infections and Treatments
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
IRCCS Humanitas Research Hospital
2012-2025
Humanitas University
2004-2024
Istituti di Ricovero e Cura a Carattere Scientifico
1996-2022
Centro Cardiologico Monzino
1989-2020
University of Milan
1988-2019
Ospedale Papa Giovanni XXIII
2016
University Hospital Bonn
2013
Fondazione Humanitas per la Ricerca
2002-2012
Humanitas Gavazzeni
2002-2008
Ministero della Salute
2008
BackgroundCoronavirus disease 2019 (COVID-19) is associated with a high burden 10% of confirmed cases progressing towards critical illness. Nevertheless, the course and predictors mortality in critically ill patients are poorly understood.MethodsFollowing developments ICUs regions experiencing early inception pandemic, European-based, international RIsk Stratification COVID-19 Intensive Care Unit (RISC-19-ICU) registry was created to provide near real-time assessment developing illness due...
Rabbit antibodies against components of the human milk fat globule bind specifically to normal breast epithelial cells and cell lines derived from carcinomas, as well outer surface globule. Variation in indirect immunofluorescence staining both intensity per percentage stained is observed for different brest lines. Cells other ectodermal tissues, fetal fibroblasts, blood buffy coat, even fibroblasts itself do not antibodies. This suggests that these are detecting cell-type-specific antigens....
Background: Hepatocellular carcinoma (HCC) is the most frequent liver malignancy and a leading cause of cancer death in world. In unresectable HCC patients, transcatheter arterial (chemo-) embolization (TAE/TACE) has shown disease response 15–55% cases. Though multiple TAE/TACE courses can be administered principle, Stereotactic Body Radiotherapy (SBRT) emerged as an alternative option case local relapse following courses. Methods: This single-center, prospective, randomized, controlled,...
ABSTRACT Background and Aims Management of ultrasound (US)‐guided percutaneous liver biopsy (PLB) lacks standardisation. Despite the low risk major complications (< 1%), repeated blood counts up to 4 h in‐hospital observation are typically recommended. We aimed assess complication rates predictors in a large cohort patients undergoing US‐PLB across three Italian tertiary centres. included all from January 2018 December 2023. collected clinical, biochemical procedural features (needle...
Heterologous specific antisera against human mammary epithelial antigens (HME-Ags), which are present in the milk fat globule membrane and breast cells, were used a solid-phase radioimmunoassay to determine presence of these sera patients with disseminated cancer other organs. Breast carry high levels HME-Ags their circulation, while nonbreast cancer, as well normal female controls, do not. A similar release circulation was shown by us model system. To further corroborate findings,...
Accurate risk stratification of critically ill patients with coronavirus disease 2019 (COVID-19) is essential for optimizing resource allocation, delivering targeted interventions, and maximizing patient survival probability. Machine learning (ML) techniques are attracting increased interest the development prediction models as they excel in analysis complex signals data-rich environments such critical care.We retrieved data on COVID-19 admitted to an intensive care unit (ICU) between March...
Objective: To assess the preventive effect of antioxidant N-acetylcysteine on postoperative acute renal failure in patients with insufficiency undergoing cardiac surgery. Design: Randomized, placebo-controlled, prospective study. Setting: University cardiology center. Patients: Two hundred fifty-four consecutive chronic (estimated creatinine clearance ≤60 mL/min) elective Interventions: Patients were randomized to receive (n = 129) or placebo 125). group received four boluses intravenous...
Hyperferritinemia, a common feature of nonalcoholic fatty liver disease (NAFLD), has been associated with steatohepatitis and fibrosis. Heterozygosity for α1-antitrypsin (AAT) mutations is cofactor damage, AAT influences inflammation iron metabolism. This study evaluated the prevalence PiS/PiZ mutants in 353 patients NAFLD, 195 whom had hyperferritinemia, versus 114 matched controls their influence on metabolism severity damage 212 submitted to biopsy. PiS PiZ alleles were searched by...
Most patients with serum hepatitis C virus (HCV) RNA and persistently normal alanine transaminase (ALT) levels show histological features of mild to moderately active chronic hepatitis. Some cirrhosis has also been reported. To assess whether interferon (IFN) treatment led long-term HCV suppression in these patients, 31 previously untreated (15 men, 16 women; mean age, 44 years) RNA, ALT on at least four consecutive occasions 2 months apart, (21 activity, 10 moderate activity) were...
It has been suggested that iron depletion improves the response to interferon in patients with chronic hepatitis C. We aimed evaluate whether reduction by phlebotomy before rate of virological sustained previously untreated noncirrhotic patients.One hundred fourteen C virus (HCV) RNA positive hepatic concentrations > or =700 microg/g dry wt (men) and =500 (women), stratified according HCV genotype gamma-glutamyltransferase values, were randomly allocated alone (6 MU three times a week)...
Sarcopenia has been associated with lower overall survival in patients cirrhosis and hepatocellular carcinoma (HCC) undergoing surgical resection, TACE, TARE, or transplantation. This monocentric study evaluated the prognostic significance of sarcopenia affected by HCC who received bland transarterial embolization (TAE) therapy, analyzing its impact on treatment-related complications. All consecutive underwent 1st TAE between March 2011 July 2019 our Institution were retrospectively studied....