A5073105104- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- Peripheral Artery Disease Management
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Respiratory Support and Mechanisms
- Muscle and Compartmental Disorders
- Protease and Inhibitor Mechanisms
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Nutrition and Health in Aging
- Obesity and Health Practices
- Liver Diseases and Immunity
- Renal function and acid-base balance
- Thyroid Disorders and Treatments
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Parvovirus B19 Infection Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease and Transplantation
Copenhagen University Hospital
2022-2025
Rigshospitalet
2022-2025
People with HIV (PWH) have a high risk of coronary artery disease (CAD). Cytomegalovirus (CMV) co-infection is very common in PWH, but little known about its association CAD. We aimed to investigate if CMV IgG serostatus and concentrations are associated CAD PWH. From the Copenhagen Comorbidity Infection (COCOMO) Study we included PWH CT angiography (CCTA) quantitative concentration measurements. measured stenosis grades plaque volumes vessels. Using multivariable regressions adjusted for...
Low muscle mass and chronic lung disease are common among people with HIV (PWH), but whether low is associated a faster decline in function this population remains unknown. We aimed to determine the prevalence factors of mass, association between PWH. Prospective study on PWH from Copenhagen Comorbidity Infection (COCOMO) study. Skeletal index (SMI) was assessed computed tomography defined as SMI below lowest 5% healthy population. Lung measured forced expiratory volume 1 second (FEV1) at...
People with HIV (PWH) have a high risk of peripheral artery disease (PAD), and high-sensitivity troponin (hsTnT) NT-pro B-type natriuretic peptide (NT-proBNP) may be useful biomarkers for PAD in PWH. We assessed associations between hsTnT NT-proBNP both prevalent de novo PAD. Adult PWH were examined at baseline after 2 years. Inclusion criteria (1) measurements (2) ankle brachial index (ABI) visits was defined as ABI ≤ 0.9. included 1011 PWH, 88 (8.7%) had baseline. Among 802 29 (3.6%)...
Abstract The prevalence of hyperthyroidism and hypothyroidism associated risk factors are unknown in liver transplant recipients. We aimed to determine the recipients compare it with controls from general population. As part Danish Comorbidity Liver Transplant Recipients (DACOLT) Study, all over age 20 were invited for measurements concentrations thyrotropin thyroid hormones. was compared age- sex-matched Copenhagen General Population Study. Using logistic regression adjusted age, sex,...
Objective: Atherosclerosis is common in people with HIV (PWH). Peripheral artery disease (PAD) the peripheral manifestation of atherosclerosis, but little known about incidence PAD PWH. Our objective was to determine PWH and investigate potential risk factors. Design: Prospective longitudinal study on from Copenhagen Comorbidity Infection (COCOMO) cohort. Methods: We performed ankle-brachial index (ABI) measurements at entry 2-year follow-up included participants normal ABI entry. defined de...
People with HIV (PWH) have an increased risk of peripheral artery disease (PAD), but the pathogenesis is unknown. We aimed to determine associations between markers endothelial dysfunction and platelet activation both PAD at baseline de novo in PWH.In total, 1012 PWH from longitudinal Copenhagen Comorbidity HIV-infection (COCOMO) study 57 age-matched sex-matched population controls were included. Plasma samples collected analyzed for soluble thrombomodulin, syndecan-1, CD40 ligand (sCD40L)....
Life-long immunosuppressive treatment after liver transplantation (LT) prevents graft rejection but predisposes the LT recipient to infections. Herpesvirus infections are associated with morbidity and mortality among recipients. Among those, especially cytomegalovirus (CMV) varicella-zoster virus (VZV) pose challenges LT. The aim of this study is provide an in-depth characterization cellular immune response against CMV VZV in recipients identify potential risk factors for infection.
Fraction of exhaled nitric oxide with an expiratory flow 50 mL/s (FENO50) is a biomarker eosinophilic airway inflammation. Liver transplant recipients have increased risk pulmonary infections, but little known about the burden chronic diseases in this group. We aimed to assess prevalence elevated FENO50 liver and compare it controls from general population. was measured 271 The Danish Comorbidity Transplant Recipients (DACOLT) study 1,018 age- sex-matched Copenhagen General Population Study...
Weight gain effects of Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in people with HIV (PWH) have been sparsely studied.Participants were enrolled the Copenhagen Comorbidity Infection (COCOMO) study. PWH receiving a backbone emtricitabine, or lamivudine combined abacavir, tenofovir disoproxil, alafenamide analysed. according to ART and third drug was analysed using multiple linear regression model. Non-ART risk factors also determined regression.A total 591 participants included...
Abstract Background Kidney transplant recipients receive maintenance immunosuppressive therapy to avoid allograft rejection resulting in increased risk of infections and infection-related morbidity mortality. Approximately 98% adults are infected with varicella zoster virus, which upon reactivation causes herpes zoster. The incidence is higher kidney than immunocompetent individuals, at severe zoster-associated disease. Vaccination adjuvanted recombinant glycoprotein E subunit vaccine (RZV)...