A5009960658- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Preterm Birth and Chorioamnionitis
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Maternal and Perinatal Health Interventions
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Pregnancy-related medical research
- Pelvic floor disorders treatments
- Bariatric Surgery and Outcomes
- Gestational Diabetes Research and Management
- Vascular Anomalies and Treatments
- Organ and Tissue Transplantation Research
- Microbial infections and disease research
- Diabetes and associated disorders
- Pancreatitis Pathology and Treatment
- Urticaria and Related Conditions
- Ovarian cancer diagnosis and treatment
Queen Charlotte's and Chelsea Hospital
2011-2024
Animal and Plant Health Agency
2023-2024
Royal Veterinary College
2012-2023
University of London
2012-2021
Imperial College Healthcare NHS Trust
2014-2021
National Health Service
2020-2021
University of Oxford
2020
UCL Biomedical Research Centre
2020
NIHR Clinical Research Network
2020
Queen Alexandra Hospital
2014-2020
Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with rates stillbirth, preterm birth, neonatal unit admission. Ursodeoxycholic widely used as a treatment without an adequate evidence base. We aimed to evaluate whether ursodeoxycholic reduces adverse perinatal outcomes in women intrahepatic pregnancy.We did double-blind, multicentre, randomised placebo-controlled trial at 33 hospital maternity units England...
Peste des petits ruminants (PPR) is an important cause of mortality and production loss among sheep goats in the developing world. Despite control efforts a number countries, it has continued to spread across Africa Asia, placing increasing burden on livelihoods livestock keepers veterinary resources affected countries. Given similarities between PPR rinderpest, lessons learned from successful global eradication seems appealing, both eliminating disease improving poor We conducted...
Transboundary animal diseases can have very severe socio-economic impacts when introduced into new regions. The history of disease incursions the European Union suggests that initial outbreaks were often initiated by illegal importation meat and derived products. would benefit from decision-support tools to evaluate risk introduction caused imports in order inform its surveillance strategy. However, due difficulty quantifying movements products, few studies this type been conducted. Using...
Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that caused by PPR virus, member the genus Morbillivirus includes viruses cause rinderpest (RP) in cattle. RP was first animal to be globally eradicated 2011 only second disease, after smallpox, have ever been eradicated. one principal constraints small ruminant production Africa, Asia, Middle East. The epidemiology as well technologies available for their diagnosis control are similar. conditions favored...
Hereditary haemorrhagic telangiectasia (HHT) is a complex, multisystemic vascular dysplasia affecting approximately 85,000 European Citizens. In 2016, eight founding centres operating within 6 countries, set up working group dedicated to HHT what became the Reference Network on Rare Multisystemic Vascular Diseases. By launch, combined experience exceeded 10,000 patients, and Chairs representing 7 separate specialties provided median of 24 years' in HHT. Integrated were expert patients who...
We have developed an immunochromatographic test for the diagnosis of peste des petits ruminants (PPR) under field conditions. The diagnostic assay has been tested in laboratory and also conditions Ivory Coast, Pakistan, Ethiopia Uganda. is carried out on a superficial swab sample (ocular or nasal) showed sensitivity 84% relative to PCR. specificity was 95% over all nasal ocular samples. detected as little 10(3) TCID50 (50% tissue culture infectious doses) cell culture-grown virus, virus...
The complexity and connectedness of eco-social processes have major influence on the emergence spread infectious diseases amongst humans animals. disciplinary nature most research activity has made it difficult to improve our understanding interactions feedback loops within relevant systems. Influenced by One Health approach, increasing efforts recently been address this knowledge gap. Disease is strongly influenced host density contact structures, pathogen characteristics population...
Abstract Hereditary haemorrhagic telangiectasia (HHT) is a multisystemic vascular dysplasia inherited as an autosomal dominant trait. Approximately 10 % of patients have cerebral malformations, proportion being arteriovenous malformations (AVMs) and fistulae that may lead to potentially devastating consequences in case rupture. On the other hand, detection treatment related-risks are not negligible, immediate. While successful can be undertaken individual cases, current data do support...
Peste des petits ruminants (PPR) is a viral disease of goats and sheep that occurs in Africa, the Middle East Asia with severe impact on livelihoods livestock trade. Many wild artiodactyls are susceptible to PPR virus (PPRV) infection, some outbreaks have threatened endangered populations. The role species PPRV epidemiology unclear, which knowledge gap for Global Strategy Control Eradication PPR. These studies aimed investigate infection Greater Serengeti Amboseli ecosystems Kenya Tanzania....
To assess the safety and efficacy of long term prophylactic use rofecoxib (a COX-2-specific inhibitor) in women at high risk preterm delivery.A randomised, double-blind, placebo-controlled trial.Queen Charlotte's Chelsea Hospital, London Guys St Thomas' Hospitals, London.Ninety-eight singleton pregnancies labour.Treatment from 16 to 32 weeks. Weekly ultrasound surveillance.Fetal renal function ductus arteriosus blood flow changes. Preterm delivery rates neonatal outcome.Rofecoxib caused a...
The recent occurrence and spread of African swine fever (ASF) in Eastern Europe is perceived as a serious risk for the pig industry European Union (EU). In order to estimate potential ASF virus (ASFV) entering EU, several pathways introduction were previously assessed separately. present work aimed integrate five these assessments (legal imports pigs, legal products, illegal fomites associated with transport wild boar movements) into modular tool that facilitates visualization comprehension...
Abstract Peste des petits ruminants (PPR) is a highly contagious and devastating viral disease affecting mainly sheep goats, but also large number of wild species within the order Artiodactyla. A better understanding PPR transmission dynamics in multi-host systems necessary to efficiently control disease, particular where wildlife livestock co-occur. Notably, role epidemiology still not clearly understood. Non-invasive strategies detect infection without need for animal handling could...
Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported 2007 Germany and subsequently observed at low incidence other European countries New Zealand. A multi-country matched case-control study conducted 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms Belgium, France, the Netherlands by laboratory confirmation of farmer-reported cases. Up four similar age same farm...
Participatory surveillance (PS) is the application of participatory rural appraisal methods to collection epidemiological information inform decision-making and action. It was applied in Africa Asia as part emergency programs address H5N1 highly pathogenic avian influenza (HPAI) pandemic. The approach resulted markedly increased case detection countries experiencing HPAI, a better understanding situation. Where HPAI absent PS implemented, method did not result false positives contributed...
Peste des petits ruminants (PPR) disease was first confirmed in Tanzania 2008 sheep and goats Ngorongoro District, northern Tanzania, is now endemic this area. This study aimed to characterise PPR pastoralist small ruminant flocks District. During June 2015, 33 PPR-like reports were investigated different parts of the district, using semi-structured interviews, clinical examinations, virus rapid detection test (PPRV-RDT), laboratory analysis. Ten as PPRV infected by PPRV-RDT and/or real-time...