A5032299143- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Pregnancy and Medication Impact
- Pregnancy-related medical research
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Gestational Diabetes Research and Management
- Global Maternal and Child Health
- Ectopic Pregnancy Diagnosis and Management
- Endometriosis Research and Treatment
- Healthcare Policy and Management
- COVID-19 Impact on Reproduction
- Meta-analysis and systematic reviews
- Uterine Myomas and Treatments
- Ethics in Clinical Research
- Ethics and Legal Issues in Pediatric Healthcare
- Pelvic floor disorders treatments
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
University of Nottingham
2016-2025
Nottingham University Hospitals NHS Trust
2010-2024
University of Oxford
2000-2023
Nottingham City Hospital
2013-2022
Queen Mary University of London
2016-2022
Foundation Medicine (United States)
2022
Dallas County
2022
Southmead Hospital
2022
University of Birmingham
2022
United Lincolnshire Hospitals NHS Trust
2021
The effects of less-tight versus tight control hypertension on pregnancy complications are unclear.
To compare the effect of induction labour with a policy expectant monitoring for intrauterine growth restriction near term.
Progesterone administration has been shown to reduce the risk of preterm birth and neonatal morbidity in women at high risk, but there is uncertainty about longer term effects on child.We did a double-blind, randomised, placebo-controlled trial vaginal progesterone, 200 mg daily taken from 22-24 34 weeks gestation, pregnancy infant outcomes (because previous spontaneous ≤34 0 days or cervical length ≤25 mm, because positive fetal fibronectin test combined with other clinical factors for [any...
Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with rates stillbirth, preterm birth, neonatal unit admission. Ursodeoxycholic widely used as a treatment without an adequate evidence base. We aimed to evaluate whether ursodeoxycholic reduces adverse perinatal outcomes in women intrahepatic pregnancy.We did double-blind, multicentre, randomised placebo-controlled trial at 33 hospital maternity units England...
The risk of antepartum stillbirth at term is higher among women 35 years age or older than younger women. Labor induction may reduce the stillbirth, but it also increase cesarean delivery, which already common in this group.We conducted a randomized, controlled trial involving primigravid who were older. Women randomly assigned to labor between 39 weeks 0 days and 6 gestation expectant management (i.e., waiting until spontaneous onset development medical problem that mandated induction)....
To determine whether clinical outcomes differed by occurrence of severe hypertension in the international CHIPS trial (Control Hypertension Pregnancy Study), adjusting for interventions "less tight" (target diastolic blood pressure [dBP] 100 mm Hg) versus "tight" control dBP 85 Hg). In this post-hoc analysis data from 987 women with nonsevere nonproteinuric preexisting or gestational hypertension, mixed effects logistic regression was used to compare following according allocated group and...
BackgroundIn women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease progression needs be balanced against infant complications. The aim this trial was determine whether planned earlier initiation reduces adverse outcomes without substantial worsening neonatal or outcomes, compared expectant management (usual care) in pre-eclampsia.MethodsIn parallel-group, non-masked, multicentre, randomised controlled done 46 maternity...
To propose a checklist that can be used to assess trustworthiness of randomized controlled trials (RCTs).
To compare the effect of delivering early to pre-empt terminal hypoxaemia with delaying for as long possible increase maturity.
Currently, clinical trials tend to be individually funded and applicants must include a power calculation in their grant request. However, conventional levels of statistical precision are unlikely obtainable prospectively if the trial is required evaluate treatment rare disease. This means that clinicians treating such diseases remain ignorance form judgments solely on basis (potentially biased) observational studies experience, anecdote. Since some unbiased evidence clearly better than...
Nicotine-replacement therapy is effective for smoking cessation outside pregnancy and its use widely recommended during pregnancy. We investigated the efficacy safety of nicotine patches pregnancy.We recruited participants from seven hospitals in England who were 16 to 50 years age with pregnancies 12 24 weeks' gestation smoked five or more cigarettes per day. Participants received behavioral support randomly assigned 8 weeks treatment active (15 mg hours) matched placebo patches. The...
<b>Objectives</b> To evaluate current processes by which young children presenting with a febrile illness but suspected of having serious bacterial infection are diagnosed and treated, to develop test multivariable model distinguish infections from self limiting non-bacterial illnesses. <b>Design </b>Two year prospective cohort study. <b>Setting </b>The emergency department The Children's Hospital at Westmead, Australia. <b>Participants</b> Children aged less than 5 years between 1 July 2004...
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder associated with an increased risk adverse fetal outcomes. It characterised by raised maternal serum bile acids, which are believed to cause the ICP commonly treated ursodeoxycholic acid (UDCA). This study aimed determine and profiles in normal pregnancies, examine effect UDCA treatment. Matched umbilical cord samples were collected from untreated (n = 18), UDCA-treated 46) uncomplicated 15) cases at time...