A5035183190- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Systemic Sclerosis and Related Diseases
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Effects of Exercise
- Cardiac Fibrosis and Remodeling
- Extracellular vesicles in disease
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Proteoglycans and glycosaminoglycans research
- Acute Myocardial Infarction Research
- Analytical Methods in Pharmaceuticals
- Erythrocyte Function and Pathophysiology
- Receptor Mechanisms and Signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Umeå University
2010-2024
University Hospital of Umeå
1996-2015
Uppsala University Hospital
1990-2014
Uppsala University
1989-2010
University of Gothenburg
1977-2010
Karolinska University Hospital
1973-2009
Karolinska Institutet
2009
Lund University
2003-2009
West Middlesex University Hospital
2008
Faculty of Public Health
2007
Background— Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept heart failure. Methods Results— Patients with New York Heart Association class II to IV chronic failure left ventricular ejection fraction ≤0.30 were enrolled 2 trials that differed only doses of used. In RECOVER, patients received placebo (n=373) or subcutaneous 25 mg every week (n=375) twice per (n=375)....
Patients with diabetes have an unfavourable prognosis after acute myocardial infarction. In the first DIGAMI study, insulin-based glucose management improved survival. 2, three treatment strategies were compared: group 1, insulin-glucose infusion followed by long-term control; standard and 3, routine metabolic according to local practice.DIGAMI 2 recruited 1253 patients (mean age 68 years; 67% males) type suspected infarction randomly assigned groups 1 (n=474), (n=473), 3 (n=306). The...
Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until now technological limitations have hindered elucidation of the contribution all clinically relevant disease DCM phenotypes in larger cohorts. We utilized next-generation sequencing overcome these and screened a large cohort. In this multi-centre, multi-national study, we enrolled 639 patients with sporadic or familial DCM. To samples, applied standardized protocol for ultra-high coverage 84 genes, leading 99.1%...
Shedding microvesicles are membrane released vesicles derived directly from the plasma membrane. Exosomes of late endosomal origin that share structural and biochemical characteristics with prostasomes. Microvesicles/exosomes can mediate messages between cells affect various cell-related processes in their target cells. We describe newly detected microvesicles/exosomes cardiomyocytes depict some biological functions.Microvesicles/exosomes media cultured adult mouse heart were isolated by...
Abstract Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use new imaging technologies, advances large‐scale ‘omics’ epidemiological analyses to extensively characterize a cohort 30 000 men women aged between 50 64 years. information obtained will used improve prediction cardiopulmonary...
Dilated cardiomyopathy (DCM) is a major cause of heart failure with high familial recurrence risk. So far, the genetics DCM remains largely unresolved. We conducted first genome-wide association study (GWAS) to identify loci contributing sporadic DCM. One thousand one hundred and seventy-nine patients 1108 controls contributed discovery phase. Pools DNA stratified on disease status, population, age, gender were constituted used for testing 517 382 single nucleotide polymorphisms (SNPs)....
During a double-blind trial in which patients with suspected myocardial infarction received metoprolol or placebo, we analyzed the occurrence of ventricular tachyarrhythmias. Metoprolol (15 mg intravenously) was given as soon possible after admission, and thereafter 200 daily for three months. Antiarrhythmic drugs were only fibrillation sustained tachycardia (greater than 60 beats per second). Definite acute developed 809 1395 participants, probable 162. did not influence premature...
Diabetic patients with acute myocardial infarction have a poor prognosis, which has been attributed to higher incidence of congestive heart failure and fatal reinfarction. This study reports on the one-year morbidity mortality in randomized aim testing whether insulin-glucose infusion initiated as soon possible after onset followed by long-term subcutaneous insulin treatment may beneficial effect outcome diabetic patients. In all, 306 were recruited insulin-treated group, while 314 served...
Nested polymerase chain reaction (nPCR) demonstrated the presence of Chlamydia pneumoniae-specific DNA in peripheral blood mononuclear cells (PBMC). PBMC samples were obtained from 103 consecutive patients (62 male, 41 female) aged 22–85 years (mean, 64) admitted for coronary angiography because suspected heart disease and 52 donors (43 9 40–64 49). Of 101 evaluable patients, 60 (59%) identified by nPCR assay as C. pneumoniae carriers; microimmunofluorescence (MIF) serology confirmed...
The aim of the present study was to describe regional and global right ventricular (RV) function in a wide age range healthy subjects both sexes. We studied 255 (125 females) individuals randomly selected from Umeå General Population Register, 58 ± 19 (range 22–89) years. RV using myocardial tissue Doppler imaging free wall. Isovolumic contraction (IVCv), systolic (Sv), early (Ev), late (Av) diastolic velocities were measured. Furthermore, isovolumic periods ejection time intervals also...
Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re‐differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules chemical class acylated hydrazones salicylaldehydes specifically blocks T3SS Chlamydia . These compounds also affect developmental cycle showing pivotal role pathogenesis Our results...
Exosomes are nano-sized extracellular vesicles, released from various cells, which can stimulate or repress responses in targets cells. We recently reported that cultured cardiomyocytes able to release exosomes and they, turn, involved facilitating events target cells by alteration of gene expression. investigated whether external stimuli the cardiomyocyte might influence transcriptional content exosomes. were isolated media collected (HL-1) with without growth factor treatment (TGF-β2...
Left ventricular hypertrophy (LVH) was produced in guinea pigs after aortic stenosis (AS). The percentage of LVH AS determined by normalizing left (LV) weight the mean LV sham-operated controls (n = 12). After 3 weeks cardiac overload, a mild (30 +/- 3%) induced 17 animals and relatively severe (56 7 animals. papillary muscles were rapidly excised for mechanical studies. No significant differences observed between control groups. In contrast, marked decrease myocardial performance seen more...
Experimental myocardial infarction was induced in rats. The accumulation of hyaluronan (HA) and water during the development measured. extractable HA content infarcted area increased progressively from day 1 on 3 reached a threefold increase compared with amounts myocardium sham operated controls. relative areas also reaching maximum value by strongly correlated accumulation. Affinity histochemistry visualized thin rim endoperimysium healthy myocardium. By 2 an interstitial edema...
To explore if hypoglycaemic episodes during hospitalisation influence the subsequent prognosis in patients with diabetes and acute myocardial infarction.Within framework of clinical trial DIGAMI 2 (blood glucose <3.0 mmol/l or without symptoms) were recorded 1253 (mean age 68 years; 67% males) type infarction. The followed a median 2.1 years. A total 947 randomised to an initial insulin infusion while 306 received routinely used lowering therapy.Unadjusted adjusted (age, sex, smoking,...