A5081804481- Viral-associated cancers and disorders
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Infectious Encephalopathies and Encephalitis
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Frailty in Older Adults
- Infective Endocarditis Diagnosis and Management
- Biosensors and Analytical Detection
- Nutrition and Health in Aging
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Antifungal resistance and susceptibility
Centre Hospitalier Universitaire de Montpellier
2016-2025
Inserm
2016-2025
Institut de Recherche pour le Développement
2014-2024
Université de Montpellier
2013-2024
La Roche College
2024
Centre Hospitalier Universitaire de Nîmes
2024
Hospital for Tropical Diseases
2022
Centre Hospitalier Régional et Universitaire de Nancy
2022
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2022
Recherches Translationnelles sur le VIH et les Maladies Infectieuses
2014-2021
Environmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, they associated with neuronal impairment acute or chronic inflammation. Alzheimer's disease (AD) is characterized by progressive synaptic dysfunction neurodegeneration that ultimately lead dementia. Neuroinflammation also plays a prominent role AD possible links viruses have been proposed. In particular, human immunodeficiency virus (HIV) can pass...
We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to hospital during coronavirus disease 2019 (COVID-19) outbreak for suspicion severe acute respiratory syndrome 2 infection. Monocyte was strongly overexpressed 30 32 (93.7%) confirmed COVID-19 cases, compared with 3 21 (14.3%) whom diagnosis finally ruled out. associated plasma interferon-alpha level and thrombocytopenia. testing may be helpful...
Abstract Covid-19 crisis showed us that rapid massive virus detection campaign is a key element in SARS-CoV-2 pandemic response. The classical RT-PCR laboratory platforms must be complemented with and simplified technologies to enhance efficiency of large testing strategies. To this aim, we developed EasyCOV, direct saliva RT-LAMP based assay do not requires any RNA extraction step. It allows robust response under safe easy conditions for healthcare workers patients. EasyCOV test was...
Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical syndrome for whom thalidomide treatment induced rapid clinical remission permitted complete withdrawal without relapse.
We report three unrelated cases of Zika virus infection in patients returning from Martinique, Brazil and Colombia respectively, to Montpellier, France. They developed symptoms compatible with a mosquito-borne disease, serological molecular investigations indicated recent infection. Considering the warning for likely teratogenicity presence competent mosquito vectors southern France, these highlight need awareness physicians laboratories Europe.
Background. The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of renin aldosterone system (RAAS), as cellular receptor to infect cells. Since RAAS can induce and modulate pro-inflammatory responses, it could play key role in pathophysiology Covid-19. Thus, we aimed determine levels plasma indicators activation series consecutively admitted patients our clinic. Methods. Plasma were measured, among...
The implementation of rapid diagnostic tests (RDTs) may enhance the efficiency severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing, as RDTs are widely accessible and easy to use. aim this study was evaluate performance a diagnosis strategy based on combination antigen immunoglobulin M (IgM) or G (IgG) serological RDTs. Plasma nasopharyngeal samples were collected between 14 March 11 April 2020 at hospital admission from 45 patients with reverse transcription polymerase chain...
To assess the efficacy of inhaled ciclesonide in reducing risk adverse outcomes COVID-19 outpatients at developing severe illness.COVERAGE is an open-label, randomized controlled trial. Outpatients with documented COVID-19, factors for aggravation, symptoms ≤7 days, and absence criteria hospitalization are randomly allocated to either a control arm or one several experimental arms, including ciclesonide. The primary endpoint worsening (hospitalization, oxygen therapy home, death) by Day 14....
Objectives The aim of the study was to describe a new evolutionary form visceral leishmaniasis observed in immunocompromised patients. Methods We carried out long‐term clinical and biological follow‐up 10 HIV‐1/ Leishmania ‐coinfected patients presenting numerous secondary episodes despite treatment, with time ranging from 0.5 years. Results Analysis polymerase chain reaction (PCR) blood culture results demonstrated continuous multiplication circulation parasites both during asymptomatic...
The purpose of this study was to assess the short- and long-term outcomes HIV-infected patients admitted intensive care units (ICU) according immunovirological status at admission highly active antiretroviral therapy (HAART) use in ICU.Retrospective 98 hospitalized between 1997 2008 two medical ICU Montpellier, France. primary outcome mortality ICU. secondary end point probability survival year following admission.Eighty-two (83.6%) admissions were related HIV infection 45% had received...
Lung cancer screening with chest computed tomography (CT) is beneficial in smokers aged 55 to 74 years. We studied the risks, benefits and feasibility of early lung diagnosis CT HIV-infected smokers. French, multicentre, single round study France, realized between February 2011 June 2012. Patients were at least 40 years, 20 pack-years, a CD4 T-lymphocyte nadir count below 350 cells/μl. Single proposed standardized workup algorithm positive images. The outcome was number histologically proven...
To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), a focus on neuropsychiatric adverse events (NPAEs). Patients 18 HIV reference centres France prospectively included Dat'AIDS cohort. Data collected from all starting INSTI-containing regimen between 1 January 2006 31 December 2016. All discontinuations analysed, patients' characteristics related to due NPAEs sought. INSTIs prescribed 21315...
Abstract Background Integrase strand transfer inhibitors (INSTIs) are increasingly used in patients living with HIV due to their safety, effectiveness and high genetic barrier. However, an association weight gain has recently been suggested several cases of diabetes mellitus have reported raltegravir dolutegravir. The long-time metabolic impact these recent molecules remains unclear. Objectives To assess if INSTI as a third agent is statistically associated new-onset compared NNRTI or PI....
Cancer risk is higher in people living with HIV (PLWH) compared the general population, and cancers related to age are expected be most prevalent.We determined spectrum incidence rates of AIDS-defining (ADC) non-AIDS-defining (NADC) lung, Hodgkin lymphoma (HL), head neck (HNC), colon-rectum, anal, liver, breast, prostate, urinary bladder between January 2010 December 2015 French Dat'AIDS cohort. Incidence were calculated by year using χ2 test for linear trend. Standardized ratios [SIR (95%...
While several studies from China have reported COVID-19-related liver injury, there are currently no data on dysfunction in hospitalized COVID-19 patients Europe. The aim of this study was to describe the prevalence and predictive value abnormal function with COVID-19. This a retrospective cohort confirmed two referral hospitals France. Clinical, biological radiological were collected analysed. In all, 234 by RT-PCR included. Liver 66.6% admission. multivariate logistic regression, test...
Despite viral suppression with antiretroviral therapy, immune nonresponders (INR) among people living HIV (PLWH) still have a higher risk of developing AIDS-related and non-AIDS-related complications. Our study aimed to investigate the phenotype functions Natural Killer (NK) cells in INR, better understand underlying mechanisms nonresponse. cross-sectional included PLWH aged over 45 an undetectable load sustained for at least 2 years. Participant CD4+ T-cell counts exceeded 500 cells/mm3 IR...