A5006130945- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Malaria Research and Control
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Parasites and Host Interactions
- Travel-related health issues
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Antibiotic Resistance in Bacteria
- Healthcare Systems and Practices
- Parasitic Infections and Diagnostics
- Tuberculosis Research and Epidemiology
- Herpesvirus Infections and Treatments
- T-cell and Retrovirus Studies
- Mycobacterium research and diagnosis
- Enterobacteriaceae and Cronobacter Research
- Ocular Diseases and Behçet’s Syndrome
- Pneumonia and Respiratory Infections
Université Claude Bernard Lyon 1
2015-2024
Sorbonne Paris Cité
2012-2024
Hôpital Bichat-Claude-Bernard
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Délégation Paris 7
2014-2024
Université Paris Cité
2015-2024
Centre de recherche en Epidémiologie et Santé des Populations
2014-2024
Inserm
2015-2024
Hôpitaux Universitaires Paris-Ouest
2023-2024
Bordeaux Population Health
2020-2024
Abstract Background. The efficacy of preventing perinatal transmission (PT) human immunodeficiency virus type 1 (HIV-1) depends on both viral load (VL) and treatment duration. objective this study was to determine whether initiating highly active antiretroviral therapy (ART) before conception has the potential eliminate PT. Methods. A total 8075 HIV-infected mother/infant pairs included from 2000 2011 in national prospective multicenter French Perinatal Cohort (ANRS-EPF) received ART,...
Background. Multidrug-resistant Enterobacteriaceae (MRE) are widespread in the community, especially tropical regions. Travelers at risk of acquiring MRE these regions, but precise extent problem is not known.
In this study we analyzed the influence of human immunodeficiency virus (HIV) infection on course chronic hepatitis C through multivariate analysis including age, alcohol consumption, immune status, and (HCV)-related virologic factors. Eighty HIV-positive 80 HIV-negative injection drug users included between 1980 1995 were matched according to gender, duration HCV followed-up during 52 months. The progression cirrhosis was primary outcome measure. impact HIV HCV-RNA load, histologic activity...
Objective To assess the respective value of phenotype versus genotype standard care for choosing antiretroviral therapy in patients failing protease inhibitor-containing regimens. Methods Patients with plasma HIV-1 RNA exceeding 1000 copies/ml were randomly allocated to phenotyping, genotyping, or care. Results Five-hundred and forty-one randomized, 190 192 genotyping 159 The baseline median CD4 cell count (280 × 106cells/l), level (4.3 log10 copies/ml), number drugs previously received (n =...
We report the complete genome sequence of a highly divergent strain human immunodeficiency virus type 2 (HIV-2), 96FR12034, identified in France from patient West African origin. This lineage, H, represents only third definitive instance monkey-to-human transfer SIVsm that has given rise to pathogenic HIV-2. As different "subtypes" HIV-2 are analogous groups HIV-1 we propose subtypes henceforth by renamed agreement with HIV Nomenclature Committee. The single-strain lineages C G and 96FR12034...
Objective To determine circulating viral load in HIV-2-infected individuals. Methods Viral was determined 40 adults using standardized quantitative cell and qualitative plasma viraemia assays. We also tested for proviral HIV-2 DNA single nested polymerase chain reaction (PCR) fresh lymphocytes from 27 subjects. The results were compared, on the basis of CD4+ lymphocyte count, with our published data HIV-1 infection. Results isolated peripheral blood mononuclear cells (PBMC) 19 individuals...
Intrapartum intravenous zidovudine (ZDV) prophylaxis is a long-standing component of prevention mother-to-child transmission (MTCT) human immunodeficiency virus (HIV) in high-resource countries. In some recent guidelines, ZDV no longer systematically recommended for mothers receiving combination antiretroviral therapy (cART) with low viral load. We evaluated the impact according to load and obstetrical conditions. All HIV-1-infected women delivering between 1 January 1997 31 December 2010...
We investigated the in vitro phenotypic susceptibility of HIV-2 isolates from integrase inhibitor (INI)-naive patients to INIs and its relation gene polymorphism.We determined raltegravir elvitegravir co-cultured obtained ROD reference strain 14 clinical isolates. IC(50) values were compared with those for HIV-1 strains. polymorphism was assessed 52 INI-naive enrolled French cohort.Median 2.4 0.7 nM, respectively, similar observed Overall, 38% amino acids polymorphic. The catalytic triad DDE...
We determine phenotypic susceptibility of human immunodeficiency virus type 2 (HIV-2) isolates to amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, saquinavir, and tipranavir. Saquinavir, darunavir are potent against wild-type HIV-2 should be preferred as first-line options for HIV-2-infected patients. Other protease inhibitors less active than HIV-1.
The first reports on the pandemic influenza 2009 A/H1N1v from USA, Mexico, and Australia indicated that this disease was associated with a high mortality in pregnant women. aim of study to describe compare characteristics severe critically ill non-severe women A/H1N1v-related illness France.A national registry created screen laboratory-confirmed influenza. Three hundred fifteen patients 46 French hospitals were included: 40 admitted intensive care units (severe outcomes), 111 hospitalized...
The French Hospital Database on HIV (FHDH) is a hospital-based multicentre open cohort with inclusions ongoing since 1989. research objectives focus mainly mid- and long-term clinical outcomes therapeutic strategies, as well severe AIDS non-AIDS morbidities, public health issues relative to infection. FHDH also serves describe HIV-infected patients receiving hospital care in France. includes data more than 120 000 from 70 general or university hospitals distributed throughout Patients are...
Background. Morbidity and mortality are higher among human immunodeficiency virus (HIV) exposed but uninfected (HEU) infants than unexposed infants, particularly if the mother had a low CD4 count. We investigated possible association between maternal immune depression during pregnancy risk of infection in HEU national French Perinatal Cohort (EPF). Methods. All neonates, born alive, to HIV-1–infected women enrolled EPF 2002 2010 were included. The primary outcome was first serious...
Healthy travellers to countries where carbapenemases-producing Enterobacteriaceae (CPE) are endemic might be at risk for their acquisition, even without contact with the local healthcare system. Here, we report acquisition of CPE (two OXA-181, one New Delhi metallo-beta-lactamase 1 (NDM-1)) in three healthy returning from India. The duration intestinal carriage was less than month. results indicate that recently India considered as carriage.