A5062696563- Mosquito-borne diseases and control
- HIV/AIDS Research and Interventions
- Vector-borne infectious diseases
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- Viral Infections and Vectors
- Anesthesia and Pain Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Rabies epidemiology and control
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Disaster Response and Management
- HIV, Drug Use, Sexual Risk
- Viral Infections and Outbreaks Research
- Intraocular Surgery and Lenses
- Migration, Identity, and Health
- Malaria Research and Control
- Nosocomial Infections in ICU
- Urinary Tract Infections Management
- Hemodynamic Monitoring and Therapy
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
Centre Hospitalier Andrée Rosemon
2010-2022
Société Française de Cardiologie
2022
Clinique Saint Jean Languedoc
2021
University of French Guiana
2007-2018
Inserm
2003-2015
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2015
Centre National de la Recherche Scientifique
2015
Institut de Recherche pour le Développement
2015
Institut de Veille Sanitaire
2015
Aix-Marseille Université
2015
To study immunologic and clinical responses to HAART in patients over 50 years old.A prospective cohort which included 68 hospitals France. A total of 3015 antiretroviral-naive patients, 401 whom were aged or over, enrolled following initiation HAART. The influence age on the mean CD4 cell count increase was studied by using a two-slope mixed model. Progression, defined occurrence new AIDS-defining event (ADE) death, Cox multivariate analyses.Among with baseline HIV RNA above 5 log...
Mixtures of lidocaine with a long-acting local anesthetic are commonly used for peripheral nerve block. Few data available regarding the safety, efficacy, or pharmacokinetics mixtures anesthetics. In current study, we compared effects bupivacaine 0.5% ropivacaine 0.75% alone in mixed solution equal volumes and 2% surgery after femoral-sciatic The primary end point was onset time.In double-blind, randomized 82 adults scheduled lower limb received sciatic (20 mL) femoral block (200 mg),...
The French Hospital Database on HIV (FHDH) is a hospital-based multicentre open cohort with inclusions ongoing since 1989. research objectives focus mainly mid- and long-term clinical outcomes therapeutic strategies, as well severe AIDS non-AIDS morbidities, public health issues relative to infection. FHDH also serves describe HIV-infected patients receiving hospital care in France. includes data more than 120 000 from 70 general or university hospitals distributed throughout Patients are...
To study the impact of different potent combined antiretroviral treatment (cART) on incidence HIV-associated Kaposi's sarcoma (KS) with and without visceral involvement.Patients were selected from French Hospital Database HIV, a large hospital cohort. The risk KS was estimated by using Cox proportional hazards models adjusting for age, CD4 cell nadir, HIV exposure category, prior AIDS, cART, type cART regimen. regimens distinguished according to whether they contained protease inhibitor...
Community-acquired pneumonia (CAP) is the major manifestation of Q fever, an emerging disease in French Guiana. Consequently, empirical antibiotherapy used for treatment CAP combines doxycycline and recommended amoxicillin. Our objectives were to estimate prevalence fever build a prediction rule identify patients with antibiotic guidance.A retrospective case-control study was conducted on inpatients admitted Department Infectious Diseases Cayenne Hospital from 2004 2007. Serodiagnosis...
Background Since 2021, an emergence of New Delhi metallo-β-lactamase (NDM)-14-producing Klebsiella pneumoniae has been identified in France. This variant with increased carbapenemase activity was not previously detected Enterobacterales. Aim We investigated the rapid dissemination NDM-14 producers among patients hospitals Methods All NDM-14-producing non-duplicate clinical isolates France until June 2022 (n = 37) were analysed by whole genome sequencing. The phylogeny NDM-14-producers all K....
Objectives To analyse the impact of combined antiretroviral treatment (cART) on survival with AIDS, according to nature first AIDS‐defining clinical illness (ADI); examine trends in causes (ADC) and non‐AIDS‐defining (non‐ADC) death. Methods From French Hospital Database HIV, we studied ADI subsequent France during three calendar periods: pre‐cART period (1993–1995; 8027 patients), early cART (1998–2000; 3504 patients) late (2001–2003; 2936 patients). Results The most frequent initial ADIs...
Acute Q fever is an emergent and severe disease in French Guiana. We obtained 5 Coxiella burnetii isolates from samples of patients Cayenne found epidemic clone circulating Cayenne. This has caused pneumonia endocarditis seems to be more virulent than previously described strains.
Q fever is an emergent disease in French Guiana. We compared the incidence clinical and serologic profiles between patients from Cayenne, Guiana Marseille metropolitan France during a four-year period. The annual of diagnosed acute was significantly higher Cayenne (17.5/100,000) than (1.9/100,000) ( P = 0.0004), but not endocarditis (1.29 versus 0.34/100,000). Most had (97%) pneumonia (83%) 81% 8% < 0.0001 0.0001, respectively) transaminitis more common (54% 32%; 0.0001). proportion with...
Molecular methods have become essential in the diagnosis of visceral leishmaniasis (VL) patients who AIDS. The present study aimed at (1) identifying relapse risk factors for VL and (2) assessing value long-range routine polymerase chain reaction (PCR) monitoring such patients, (3) with a view to proposing decision-making elements discontinuing specific secondary prophylaxis.A cohort 27 HIV-positive was prospectively followed up during period 5 months 9 years (median = 51 months) after first...
Elderly people are at increased risk of influenza and pneumococcal diseases. Influenza increases clinical disease incidence. Pneumococcal vaccination could therefore be a supplement to vaccination. This study evaluated all-cause mortality antibiotic consumption according elderly people's status. Its goal was demonstrate that with both vaccines decrease consumption. From 2004-10-01 2004-12-31 (3 mo), (≥ 65 y) who lived in the Gard department (South France) were offered vaccinations. Among...
Background The purpose of this study was to compare parasacral and Winnie's single- or double-injection approaches for sciatic nerve block. Methods One hundred fifty adults scheduled undergo lower limb surgery were randomized receive on the 20 ml ropivacaine, 0.75%: single bolus injection. For double injection, peroneal tibial nerves received separately 10 plus ml. Blocks performed with use stimulator (intensity < 0.5 mA, 1 Hz). method, a line drawn between posterior superior iliac spine...
Objective To assess nosocomial infection (NI) as a risk factor for death and to estimate the population-attributable of from NI. Design. A prospective cohort study patients with without Setting. Nîmes University Hospital, Nîmes, France. Patients. Patients were recruited May 7, 2001, January 10, 2003. in acute care long-term units who had NI enrolled, randomly selected matched age, sex, type (acute vs. care) length stay hospital at inclusion. Outcome Measures. Vital status within 60 days...
ABSTRACT In 2002, 80 isolates of Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs) were collected from infected patients in our hospital. Enterobacter aerogenes was the most common bacterium isolated all specimens (36.5%). The ESBLs predominantly (90%) TEM derivatives (TEM-24, TEM-3). Pulsed-field gel electrophoresis highlighted that E. , Klebsiella pneumoniae and Citrobacter koseri had a clonal propagation.
We aimed to determine the effectiveness of boosted protease inhibitor monotherapy (BPIMT) initiated as a maintenance strategy in routine care and identify predictive factors failure.Observational study FHDH-ANRS CO4 cohort.Five hundred twenty-nine virologically suppressed individuals switched BPIMT period 2006-2010, 75% had at least 12 49% 24 months follow-up. Virological failure (two consecutive HIV-RNA > 50 copies/ml or one followed by discontinuation) treatment (virological failure,...