S. Jaffuel
A5087122582- Pneumonia and Respiratory Infections
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Bacterial biofilms and quorum sensing
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis C virus research
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Pharmaceutical Practices and Patient Outcomes
- Antibiotic Use and Resistance
- Orthopedic Infections and Treatments
- Plant Pathogenic Bacteria Studies
- SARS-CoV-2 and COVID-19 Research
- Dermatological diseases and infestations
- Cystic Fibrosis Research Advances
- Syphilis Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Legionella and Acanthamoeba research
- Influenza Virus Research Studies
Centre Hospitalier Régional Universitaire de Brest
2008-2025
Inserm
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Hôpitaux Universitaires Paris-Ouest
2024
Université Paris-Saclay
2024
Centre de recherche en Epidémiologie et Santé des Populations
2024
Hôpital de l'Antiquaille
2024
Hôpital Maison Blanche
2005-2024
Hospital for Tropical Diseases
2024
Institut Pascal
2023
Intrapartum intravenous zidovudine (ZDV) prophylaxis is a long-standing component of prevention mother-to-child transmission (MTCT) human immunodeficiency virus (HIV) in high-resource countries. In some recent guidelines, ZDV no longer systematically recommended for mothers receiving combination antiretroviral therapy (cART) with low viral load. We evaluated the impact according to load and obstetrical conditions. All HIV-1-infected women delivering between 1 January 1997 31 December 2010...
BackgroundHuman metapneumovirus (hMPV) is one of the leading respiratory viruses. This prospective observational study aimed to describe clinical features and outcomes hMPV-associated lower tract infections in adult inpatients.MethodsConsecutive patients admitted 31 participating centers with an acute infection a multiplex PCR positive for hMPV were included. A primary composite end point complicated course (hospital death and/or need invasive mechanical ventilation) was used.ResultsBetween...
Pneumococcal diseases (PD) cause considerable morbidity and mortality in adults. V116 is an investigational 21-valent pneumococcal conjugate vaccine (PCV) specifically designed to protect adults from serotypes responsible for the majority of residual PD. This phase 3 study evaluated safety, tolerability, immunogenicity vaccine-experienced ≥50 years.
Abstract Objectives To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen recent years, relation previous episodes low-level viral load (LLVL). Patients and methods a first between 1 January 2015 31 December 2020 based on two NRTIs one INSTI were included if after control (two measures VL < 50 copies/mL) they had minimum additional measurements. Cox models adjusted for sex, age, acquisition...
Abstract Background Two-drug regimens based on integrase strand transfer inhibitors (INSTIs) and boosted PIs have entered recommended ART. However, INSTIs may not be suitable for all patients. We aimed to report our experience with doravirine/lamivudine as maintenance therapy in people living HIV (PLWH) followed French settings. Methods This observational study enrolled adults who initiated between 1 September 2019 31 October 2021, centres participating the Dat’AIDS cohort. The primary...
Aspirational targets to end AIDS by 2030 include having 95% of people with human immunodeficiency virus (HIV; PWH) diagnosed, treated, and controlled viral load (VL). Our objective was describe, using a large French prospective cohort, the median transition times through cascade care between 2009 2019. We analyzed patients whose first HIV diagnosis made 1 January 31 December Using Kaplan-Meier method, we estimated time linkage (from biological assessment), treatment (date antiretroviral...
Community Acute Bacterial Meningitis (CABM) is a rare infectious disease leading to important impairments. Our aim was describe CABM survivors' quality of life (QOL) 12 months post-CABM and assess its associations with sequelae.Patients included in the COMBAT cohort were evaluated one year after episode. Data collected by questionnaire, via phone calls patients. The WHOQOL-BREF used measure QOL. Hierarchical multivariate linear regressions performed.Study population composed 284 At months,...
This study aimed to compare the humoral responses mRNA COVID-19 vaccination in people living with HIV (PWH) and HIV-negative individuals.