A5006074019- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Arrest and Resuscitation
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Parvovirus B19 Infection Studies
- Blood groups and transfusion
- Long-Term Effects of COVID-19
- Airway Management and Intubation Techniques
- Cytomegalovirus and herpesvirus research
- Pleural and Pulmonary Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Urinary Bladder and Prostate Research
- Systemic Lupus Erythematosus Research
- Clinical Laboratory Practices and Quality Control
- Neutropenia and Cancer Infections
- Urinary Tract Infections Management
- Vagus Nerve Stimulation Research
- Erythrocyte Function and Pathophysiology
- Pelvic floor disorders treatments
- COVID-19 Clinical Research Studies
Assistance Publique – Hôpitaux de Paris
2018-2023
Université Paris-Saclay
2023
Inserm
2023
Hôpital Cochin
2017-2023
Centre Hospitalier Saint-Denis
2020-2023
Université Paris Cité
2018-2023
Sorbonne Université
2022
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2018-2021
Sorbonne Paris Cité
2018-2021
Délégation Paris 5
2018
Improving timeliness of pathogen identification is crucial to allow early adaptation antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples guide empirical antimicrobial adult community-acquired pneumonia (CAP), hospital-acquired (HAP), ventilator-acquired (VAP).This retrospective multicenter study was conducted four French university hospitals. Respiratory were obtained from...
Abstract Background The optimal duration of antimicrobial therapy for urinary tract infections (UTIs) in men remains controversial. Methods To compare 7 days to 14 total antibiotic treatment febrile UTIs men, this multicenter randomized, double-blind. placebo-controlled noninferiority trial enrolled 282 from 27 centers France. Men were eligible if they had a UTI and urine culture showing single uropathogen. Participants treated with ofloxacin or third-generation cephalosporin at day 1, then...
Introduction Because of the COVID-19 pandemic, intensive care units (ICU) can be overwhelmed by number hypoxemic patients. Material and methods This single centre retrospective observational cohort study took place in a French hospital where patients exceeded ICU capacity despite an increase from 18 to 32 beds. this, 59 (37%) 159 requiring were referred other hospitals. From 27th March 23rd April, consecutive who had respiratory failure or unable maintain SpO2 > 90%, receiving 10–15 l/min...
Abstract Background The 2011 4th European Conference on Infections in Leukemia (ECIL4) guidelines recommend antibiotics de-escalation/discontinuation selected febrile neutropenia (FN) patients. We aimed to assess the impact of an antimicrobial stewardship (AMS) program based these use and clinical outcomes high-risk FN Methods conducted observational study hematology department Cochin University Hospital Paris, France. An ECIL4-based de-escalation discontinuation strategy was implemented...
The gold-standard treatment for acute exacerbation of chronic obstructive pulmonary disease (ae-COPD) is non-invasive ventilation (NIV). However, NIV failures may be observed, and invasive mechanical (IMV) required. Extracorporeal CO₂ removal (ECCO₂R) devices can an alternative to intubation. aim the study was assess ECCO₂R effectiveness safety.Patients with consecutive ae-COPD who experienced failure were retrospectively assessed over two periods time: before after device implementation in...
Abstract Background Since December 2019, a global outbreak of coronavirus disease (COVID-19) is responsible for massive influx patients with acute respiratory failure in hospitals. We describe the characteristics, clinical course, and outcomes COVID-19 treated continuous positive airway pressure (CPAP) large public hospital France. Method It single centre retrospective observational cohort. From 27th March to 23rd April, consecutive who had signs or were unable maintain an SpO 2 > 90%,...
Background: Clinical and microbiological guidelines recommend treating infections caused by Enterobacter spp. with cefepime or carbapenems. The main objective of this study was to assess the risk clinical failure third generation cephalosporin (3GC) therapy compared other β-lactams for Our secondary evaluate emergence resistance during therapy. Methods: We conducted a prospective observational in seven French hospitals over an 18-month period including all patients pulmonary and/or...
Abstract Background: Acute exacerbation of chronic obstructive pulmonary disease (ae-COPD) has a gold standard treatment: non-invasive ventilation (NIV). However, this treatment sometime fails, and an invasive mechanical (IMV) is required. The extracorporeal CO₂ removal (ECCO₂R) device can be alternative to intubation. aim the study evaluate ECCO₂R efficiency safety enlighten benefit/risk compared IMV. Methods: Consecutive ae-COPD patients for whom NIV failed were retrospectively analyzed...