A5004039946- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Ferroptosis and cancer prognosis
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Otitis Media and Relapsing Polychondritis
- Autoimmune and Inflammatory Disorders
- Hematological disorders and diagnostics
- Blood disorders and treatments
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Drug-Induced Adverse Reactions
- Neutropenia and Cancer Infections
- Urticaria and Related Conditions
- Pneumocystis jirovecii pneumonia detection and treatment
- Histone Deacetylase Inhibitors Research
Princess Margaret Cancer Centre
2024-2025
University Health Network
2024
Assistance Publique – Hôpitaux de Paris
2013-2023
Université Paris Cité
2015-2023
Institut Cochin
2020-2023
Inserm
2020-2023
Hôpital Cochin
2018-2023
La Ligue Contre le Cancer
2022
Centre National de la Recherche Scientifique
2020-2022
Hôpital Saint-Antoine
2014-2021
Objective. We describe myelodysplastic syndrome (MDS)–associated systemic inflammatory and autoimmune diseases (SIADs), their treatments outcomes the impact of SIADs on overall survival in a French multicentre retrospective study. Methods. In this study, 123 patients with MDS were analysed. Results. Mean age was 70 years (s.d. 13) male:female ratio 2. The vasculitis 39 (32%) cases, CTD 31 (25%) arthritis 28 (23%) neutrophilic disorder 12 (10%) cases unclassified 13 (11%). fulfilled usual...
APR-246 is a promising new therapeutic agent that targets p53 mutated proteins in myelodysplastic syndromes and acute myeloid leukemia (AML). reactivates the transcriptional activity of mutants by facilitating their binding to DNA target sites. Recent studies solid cancers have found can also induce p53-independent cell death. In this study, we demonstrate AML death occurring early after exposure suppressed iron chelators, lipophilic antioxidants inhibitors lipid peroxidation, correlates...
Artemisinin is an anti-malarial drug that has shown anticancer properties. Recently, ferroptosis was reported to be induced by dihydroartemisinin (DHA) and linked iron increase. In the current study, we determined effect of DHA in leukemic cell lines on induction metabolism cytoprotective triggered cells. We found treatment induces early promoting ferritinophagy subsequent Furthermore, our study demonstrated activated zinc signaling, especially upregulation metallothionein (MT)....
Abstract Objectives Venetoclax combined with hypomethylating agents is a new therapeutic strategy frequently used for treating AML patients who are not eligible conventional chemotherapy. However, high response rates heterogeneous due to different mechanisms mediating resistance venetoclax such as up‐regulation of MCL‐1 expression. We thus tested the anti‐leukemic activity S63845, specific inhibitor. Methods Apoptosis induces by S63845 or without was evaluated in primary samples and cell...
Abstract Background The 2011 4th European Conference on Infections in Leukemia (ECIL4) guidelines recommend antibiotics de-escalation/discontinuation selected febrile neutropenia (FN) patients. We aimed to assess the impact of an antimicrobial stewardship (AMS) program based these use and clinical outcomes high-risk FN Methods conducted observational study hematology department Cochin University Hospital Paris, France. An ECIL4-based de-escalation discontinuation strategy was implemented...
Abstract Clonal hematopoiesis (CH) arises when a hematopoietic stem cell (HSC) acquires mutation that confers competitive advantage over wild-type (WT) HSCs, resulting in its clonal expansion. Individuals with CH are at an increased risk of developing hematologic neoplasms and range age-related inflammatory illnesses1-3. Therapeutic interventions suppress the expansion mutant HSCs have potential to prevent these CH-related illnesses; however, such not yet been identified. The most common...
This French multicenter retrospective cohort study aimed to describe the autoimmune manifestations (AIMs) associated with lymphoma among patients hospitalized between 2005 and 2016 in three University Hospitals. Among 2503 lymphoma, 108 (4.3%) had AIMs, mostly cytopenias (71.3%), neurological diseases (10.2%), kidney (6.5%), systemic vasculitis (5.6%) others. As compared 2395 without those AIMs were older (p = .01), more frequently B-cell chronic lymphocytic leukemia < .01) less diffuse...
Objective The clinical benefit of pharmaceutical cares in improving the quality-of-care outcomes is well demonstrated. Clinical pharmacy services are not systematically deployed cancer units absence economic data. aim this prospective, observational 1-year study was to evaluate clinical, and organisational impacts care into a multidisciplinary day hospital for patients treated with oral drugs. Methods All pharmacists' interventions (PI) were documented their impact probability adverse drug...
Optimal dosing of antibiotics is critical in immunocompromised patients suspected to have an infection. Data on pharmacokinetics (PK) meropenem with haematological malignancies are scarce.To optimize regimens, we aimed develop a PK population model for this population.Patients aged ≥18 years, hospitalized the haematology department our 1500 bed university hospital malignant disease and who had received at least one dose were eligible. Meropenem was quantified by HPLC. described using...
Many salvage therapies have been proposed for relapsed/refractory (R/R) diffuse large B-cell lymphomas or consolidation in the case of suboptimal response. Radiotherapy (RT) is one modality therapy, but its place currently not well defined.
We report the case of an 82‐year old male patient admitted in our medical intensive care unit for diffuse skin lesions, 3 days after onset ceftriaxone bilateral pneumonia without microbiological documentation. The concomitantly exhibited lesions compatible with livedo and neurological haemodynamic failure. Biological analysis revealed acute haemolytic anaemia. Warming patient, red blood‐cells transfusion high‐doses corticosteroids were initiated was stopped. Despite these therapeutics,...