A5021818608- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Crystallization and Solubility Studies
- Pharmacological Effects and Toxicity Studies
- Crystallography and molecular interactions
- Epilepsy research and treatment
- Pharmaceutical studies and practices
- Poisoning and overdose treatments
- Analytical Chemistry and Chromatography
- Herpesvirus Infections and Treatments
- Chemical Thermodynamics and Molecular Structure
- Cystic Fibrosis Research Advances
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- X-ray Diffraction in Crystallography
- Blood disorders and treatments
- Pesticide Exposure and Toxicity
- Antibiotic Use and Resistance
- Inhalation and Respiratory Drug Delivery
- Sepsis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Analytical Methods in Pharmaceuticals
Université Paris Cité
2012-2024
Hôpital Cochin
2018-2024
Assistance Publique – Hôpitaux de Paris
2012-2024
Délégation Paris 5
2014-2024
Sorbonne Paris Cité
2018-2024
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2019-2024
Federal University of Technology Minna
2023
Federal Polytechnic, Bida
2023
Kwara State University
2023
The Federal Polytechnic, Ado-Ekiti
2023
Under normal environmental conditions, many plants synthesize cyanogenic glycosides, which are able to release hydrogen cyanide upon hydrolysis. Each year, there frequent livestock and occasional human victims of consumption. The present work aims determine the hydrocyanic acid content in different samples plants, selected from Tunisian flora, almond syrup. In order evaluate their toxicity impact on consumer health short term as well long term, using ISO 2164-1975 NT standard, relating...
Abstract Ceftazidime‐avibactam is a novel cephalosporin/B‐lactamase inhibitor developed in the context of increasing resistance. This case reports pharmacokinetics ceftazidime‐avibactam critically ill child under continuous renal replacement (CRRT) therapy for fluid overload. The patient was 6‐month‐old female with sepsis due to bloodstream infection Stenotrophomonas maltophilia following stem cell transplantation severe combined immunodeficiency. CRRT started on Day 2. Concentrations have...
Levofloxacin, pefloxacin, ciprofloxacin and moxifloxacin are four fluoroquinolones used in the treatment of serious bacterial infections. The antibacterial activity is concentration dependent. Therefore, therapeutic drug monitoring daily clinical practice warranted to ensure therapy's efficacy prevent resistance. purpose present study was develop a method using high-pressure liquid chromatography with an ultraviolet detector for simultaneous quantification these human plasma. A 50 μL aliquot...
Acyclovir is an antiviral currently used for the prevention and treatment of herpes simplex virus (HSV) varicella-zoster (VZV) infections. This study aimed to characterize pharmacokinetics (PK) acyclovir its oral prodrug valacyclovir optimize dosing in children. Children receiving or were included this study. PK described using nonlinear mixed-effect modeling. Dosing simulations obtain trough concentrations above a 50% inhibitory concentration HSV VZV (0.
Ganciclovir is indicated for curative or preventive treatment of cytomegalovirus (CMV) infections. This study aimed to characterize ganciclovir pharmacokinetics, following intravenous and oral valganciclovir administration, optimize dosing schemes.
OBJECTIVES: Children on extracorporeal membrane oxygenation (ECMO) are at high risk of infection that may worsen prognosis. Even though treatment with beta-lactam antibiotics is frequent, dosing not adapted to altered pharmacokinetic and pharmacodynamic characteristics children ECMO. There is, therefore, a inadequate drug levels when using standard dosing. In this study, we aimed describe exposures ECMO current identify factors associated exposure. The optimal pharmacokinetic/pharmacodynamic...
Understanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after incident with ritonavir. In present paper, a comprehensive study solid-state cysteamine hydrochloride used treatment nephropathic cystinosis recently granted orphan designation by European Commission presented employing (high-pressure) calorimetry, water vapor sorption, X-ray diffraction as function temperature. A new crystal (I2/a, III) has been...
Although the efficacy of lopinavir/ritonavir has not been proven, it proposed as an off-label treatment for COVID-19. Previously, reported that plasma concentrations lopinavir significantly increase in inflammatory settings. As COVID-19 may be associated with major inflammation, assessing and safety patients is essential.Real-world data based on a retrospective study.Among 31 treated between March 18, 2020 April 1, 2020, higher were observed, which increased by 4.6-fold (interquartile range:...
Optimal dosing of antibiotics is critical in immunocompromised patients suspected to have an infection. Data on pharmacokinetics (PK) meropenem with haematological malignancies are scarce.To optimize regimens, we aimed develop a PK population model for this population.Patients aged ≥18 years, hospitalized the haematology department our 1500 bed university hospital malignant disease and who had received at least one dose were eligible. Meropenem was quantified by HPLC. described using...
The use of an integrative analytical approach allowed us to establish the intrinsic solid state stability bethanechol chloride (BC), active pharmaceutical ingredient used in treatment urinary retention. First, crystal structure monoclinic form has been described using single X-ray diffraction studies. Second, thermal analyses revealed that compound degrades upon melting, with apparent melting temperature estimated be 231 °C. No transition from orthorhombic observed, suggesting is stable one....
In Tunisia, there are about 478 species of plants commonly used in folk medicine. Medicinal and herbal remedies responsible for 2% intoxications listed by Tunisian National Poison Center. Most cases related to confusion between edible toxic lookalikes or an excessive consumption therapeutic plants. We report the case a 58-year-old man admitted Emergency Department Regional Hospital Zaghouan (Tunisia), with renal failure rhabdomyolysis. The patient reported having daily homemade tea based on...
Abstract Valproate is an old‐generation antiepileptic drug often used in children. The pharmacokinetics of valproate are noteworthy for a large and difficult to predict interindividual variability measured serum concentrations saturable protein binding. A model‐based approach personalize treatment could be relevant pediatric patients. aims this study were review all published population pharmacokinetic models children assess them by external validation determine their predictive performance....