A5028589644- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Analytical Methods in Pharmaceuticals
- X-ray Diffraction in Crystallography
- Pharmaceutical Economics and Policy
- Analytical Chemistry and Chromatography
- Pharmaceutical Quality and Counterfeiting
- Antibiotics Pharmacokinetics and Efficacy
- Safe Handling of Antineoplastic Drugs
- Pharmaceutical studies and practices
- Pesticide Residue Analysis and Safety
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Quality and Safety in Healthcare
- Arsenic contamination and mitigation
- Analytical Chemistry and Sensors
- Analytical chemistry methods development
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Treatment and Pharmacology
- Protein purification and stability
- Pharmaceutical and Antibiotic Environmental Impacts
- Ion channel regulation and function
- Crystal structures of chemical compounds
- Pharmacogenetics and Drug Metabolism
- Intellectual Property and Patents
Université Paris-Saclay
2015-2025
Centre National de la Recherche Scientifique
2024-2025
Institut des Sciences Moléculaires d'Orsay
2024-2025
Institut Gustave Roussy
2024
Université Paris-Sud
2014-2023
Hôpitaux Universitaires Henri-Mondor
2016-2023
Assistance Publique – Hôpitaux de Paris
2014-2023
Centre Hospitalier Universitaire Henri-Mondor
2016-2023
Institut Galien Paris-Saclay
2014-2023
Centre des Matériaux
2015-2020
Breast cancer is the most frequently diagnosed in women worldwide, and non-adherence to adjuvant hormonotherapy can negatively impact recurrence relapse. Non-adherence associated with side effects of hormonotherapy. Pharmacological strategies mitigate include coadministration antidepressants, however patients remain non-adherent. The aim this work was develop medicines containing both hormonotherapy, tamoxifen (20 mg), along anti-depressants, either venlafaxine (37.5 or 75 mg) duloxetine (30...
Facial angiofibromas (FA) are one of the most obvious cutaneous manifestations tuberous sclerosis complex. Topical rapamycin for has been reported as a promising treatment. Several types vehicles have used hitherto, but polymeric micelles and especially those made d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) seem to shown better skin bioavailability than so far commonly ointments. To understand influence on behavior rapamycin, we explored it through mixed combining TPGS...
Adherence to treatment is one of the major challenges in chronic diseases. Inappropriate dosage forms or bad taste are main factor for non-adherence, especially paediatric patients. 3D printed medicines could be tailored specific patients make more acceptable, however clinical implementation hospitals still limited. This study addresses challenge developing pharma-inks (mixtures drugs and excipients) semi-solid extrusion (SSE) produce chewable tablets Sulfamethoxazole (SMX) Trimethoprim...
In pharmacy, racemic compounds are often problematic, because generally only one of the enantiomers possesses therapeutic activity and it is difficult to separate them. Even though this problem likely as old pharmaceutical industry, thermodynamically obvious way separating crystals has never been studied experimentally, which by using pressure. Data have obtained on equilibria (R)- (S)-mandelic acid system a function pressure temperature. With use thermodynamic arguments including Clapeyron,...
Hypertension results in more deaths than any other risk factor and has been on the rise sub-Saharan Africa over past few decades. Generic drugs have helped improve accessibility affordability of antihypertensive therapy developing countries. However, assessment quality standards these products is important. We performed a five commonly used generic 10 African countries studied impact price quality.Drug samples were prospectively collected using standardized methods between 2012 2014....
Enantiomer resolution is much sought after for pharmaceutical applications, because many optically active drug molecules have only one pharmaceutically enantiomer. Although it always possible to force separation, will come at a cost. The present method, based on thermodynamics, provides relatively easy approach investigate whether separation can be thermodynamically spontaneous. A topological phase diagram of the binary enantiomer system 0.5 mol-fraction constructed as function temperature...
Metal carbonyls have been developed as carbon monoxide-releasing molecules (CO-RMs) to deliver CO for therapeutic purposes. The manganese-based CORM-401 has recently reported exert beneficial effects in obese animals by reducing body weight gain, improving glucose metabolism and reprogramming adipose tissue towards a healthy phenotype. Here, we report on the synthesis characterization of glyco-CORMs, obtained grafting manganese dextrans (70 40 kDa), based fact that polysaccharides facilitate...
3,4-Diaminopyridine is an active pharmaceutical ingredient for the treatment of Lambert–Eaton myasthenic syndrome (LEMS). It 3,4-diaminopyridine dihydrogen phosphate that has become choice. As part a larger study development this drug, solid-state studies have been carried out. At room temperature, crystals are monoclinic (C2/c). Dihydrogen anions H2PO4– form infinite chains parallel to b axis, and these can be considered as macroanions (H2PO4)∞. The organic cations hydrogen bonds with...
Understanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after incident with ritonavir. In present paper, a comprehensive study solid-state cysteamine hydrochloride used treatment nephropathic cystinosis recently granted orphan designation by European Commission presented employing (high-pressure) calorimetry, water vapor sorption, X-ray diffraction as function temperature. A new crystal (I2/a, III) has been...
Solid-state properties of active pharmaceutical compounds are closely related to their dissolution behavior and bioavailability, understanding phase leads better control in the drug formulation process. l-Citrulline is an amino acid, which known exhibit polymorphism; however, only structure α form reported literature. The δ has been elusive due lack good quality single crystals. It found be orthorhombic P212121 with cell parameters a, b, c respectively 14.895(5) Å, 9.852(2) 5.353(2) Å. unit...
The counterfeiting of pharmaceuticals has been detected since about 1990 and alarmingly continued to pick up steam. We have recently involved in an evaluation program some the most commonly prescribed cardiovascular drugs Africa, for analysing important number tablets or capsules obtained from different places seven African countries. A reversed-phase high-performance liquid chromatography with tandem mass spectrometry method was developed validated simultaneously control identity quantity...
The main degradation pathways of apixaban, a novel anticoagulant drug acting as factor Xa inhibitor, has been established based on the products identification using liquid chromatography coupled to multistage high resolution mass spectrometry.
Rapamycin has been used topically to treat facial angiofibromas associated with tuberous sclerosis for more than a decade. In the absence of commercial form, large number formulations have clinically tested. However, given great heterogeneity these studies, particularly regard response criteria, it was difficult know impact and thus compare relevance used. The objective this work therefore evaluate link between diffusion rapamycin physico-chemical characteristics different on Strat-M®...