A5013708336- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Fullerene Chemistry and Applications
- Liquid Crystal Research Advancements
- Synthesis and Reactivity of Heterocycles
- Molecular spectroscopy and chirality
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Graphene research and applications
- Catalytic C–H Functionalization Methods
- Boron and Carbon Nanomaterials Research
- Synthesis and biological activity
- Catalytic Cross-Coupling Reactions
- Organometallic Compounds Synthesis and Characterization
- Chemical Thermodynamics and Molecular Structure
- Surfactants and Colloidal Systems
- Natural product bioactivities and synthesis
- Multicomponent Synthesis of Heterocycles
- Organometallic Complex Synthesis and Catalysis
- Advanced Chemical Physics Studies
- Mesoporous Materials and Catalysis
- Crystal structures of chemical compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of heterocyclic compounds
Laboratoire de Chimie Physique
2007-2024
Université de Tours
2015-2024
Inserm
2016-2023
Clinical Investigation Center Plurithematic Tours
2023
Laboratoire de Chémo-biologie synthétique et thérapeutique
2021
Pharmac
2019
Infectiologie Animale et Santé Publique
2014-2018
Centre Hospitalier Universitaire de Tours
2015-2017
Laboratoire de Chimie
2001-2017
Université Hassan II Mohammedia
2006-2016
Comparative studies of the infrared (IR) and Raman spectra orthorhombic, tetragonal, rhombohedral pressure-polymerized phases ${\mathrm{C}}_{60}$ as well pressure-dimerized state have been performed at ambient conditions. The tentative assignment vibrational different has shown that they could be perfectly described by molecular symmetry polymers which are structure-forming elements crystalline polymerized phases. This allowed one to consider IR characteristic those appropriate one-...
The columnar mesophases of two series hexacatenar palladium(II) mesogens have been studied in detail by a combination X-ray diffraction on aligned and unaligned samples dilatometry. results these studies, combined with the single crystal structure determinations, allowed model molecular arrangement phases to be proposed. This differs from that generally accepted for polycatenar phases, new is proposed which accounts both existing data.
A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives was prepared using a one-pot three-component synthesis from 5-amino-1-phenyl-1H-1,2,4-triazoles, aromatic aldehydes and ethyl acetoacetate. The compound structures were confirmed by IR, 1H-NMR, 13C-NMR, HRMS X-ray analyses. biological activity these compounds as antitumor agents evaluated. Their activities against cancer cell lines (MDA-MB-231 MCF-7) tested the MTT in vitro method. Among them, 4c 4j displayed best with IC50 values...
Experimental evidence of the existence polymerized tetragonal (T) phase ${\mathrm{C}}_{60}$ as a stable high-pressure one is presented. Using different p,T paths high-pressure--high-temperature treatment, T was obtained product conversions monomeric fcc and two phases (including rhombohedral one) at 2.2 GPa 873 K. The dramatic differences in rates phase-T formation from states system testified to difference mechanisms formation. x-ray-diffraction pattern, IR, Raman spectra almost pure are
A very favorable LUMO energy for cathodic electron injection is found in the crystalline state of mesogenic red fluorescent perylene derivative 1. It one rare cases where columnar crystal structure such a compound could be established directly by X-ray investigation.
Convenient and efficient methods for the preparation of novel 6-aminoimidazo[1,2-a]pyridine derivatives are reported that utilized palladium- or copper-catalyzed methodology. The crystal structure 6-N-methylanilinoimidazo[1,2-a]pyridine 10 is also described.
A series of novel 2-[(4-phenylpiperazin-1-yl)methyl]imidazoazines and aza-analogues were prepared screened at selected dopamine, serotonin, adrenergic receptor subtypes. 2-Substituted imidazopyridines pyridazines presented high affinities selectivities for D4 dopamine receptors. Whereas functional experiments indicated neutral antagonists or weak partial agonist effects most the target compounds, 2-methoxyphenyl substituted 2-piperazinylmethylimidazopyridine 3c (PIP3EA) displayed substantial...
A very favorable LUMO energy for cathodic electron injection is found in the crystalline state of mesogenic red fluorescent perylene derivative 1. It one rare cases where columnar crystal structure such a compound could be established directly by X-ray investigation.
Organic meets inorganic: Hydrolysis of an aryl trialkynyl tin compound leads to organic–inorganic oxide–hydroxide cluster, which consists inorganic oxide core surrounded by eight fragments (see picture, left; Sn green, blue, O red, C gray, H pink). Slightly modified reaction conditions produce a hexameric cage, can be described as double-twist Möbius band right).
Abstract The Heck reaction of alkylated 2‐(trimethylsilyl)ethanesulfonyl (SES)‐protected β‐amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the performed PEG 3400 as solvent under microwave activation. Cleavage SES group with HF corresponding free benzazepine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
A simple and efficient method for synthesis of 5,7‐disubstituted pyrazolo[1,5‐ a ]pyrimidines is reported. The synthetic route involved first one‐pot two‐step 7‐substituted ]pyrimidin‐5‐ones from the reaction 3‐aminopyrazole 1 with activated alkynes. These compounds were used as key intermediates to access, excellent yields, library new ]pyrimidines, which are known their wide range biological activities, through C–O bond activation PyBroP (bromotripyrrolidinophosphonium hexafluorophosphate)...
The reactivity of 6-haloimidazo[1,2-a]pyridine toward different azoles is reported. process was shown to be highly dependent on the reaction conditions. Using copper(I) catalyst, product ipso substitution obtained. In absence copper, with cesium carbonate in N,N-dimethylformamide, a cine took place.
The 2-trimethylsilylethanesulfonyl (or SES) protecting group was compared to the tosyl (Ts) in preparation of a nitrogen-containing five-membered ring obtained by aza-Baylis-Hillman/alkylation/RCM route. While deprotection Ts-protected pyrrolines gave only pyrroles, same SES-protected compounds either pyrroles or free amine depending on conditions. were hydrogenated yield pyrrolidines with an excellent diastereoselectivity. Free HF-mediated SES group.
Hybrid materials where layers of tin oxide alternate with hydrophobic organic chains were prepared by the hydrolysis distannylated compounds containing an chain alpha,omega-disubstituted tripropynylstannyl groups. In case aliphatic chain, under microemulsion conditions led to organization corresponding hybrid. These also induced a high surface area and defined mesoporosity in When mixed aromatic-aliphatic spacer was used, weak interactions between spacers sufficient generate same type material.
The very fast and efficient water vapor absorption of the dimeric fluorous copper(II)-carboxylate complex [Cu(2)(C(8)F(17)CO(2))(4)(acetone)(2)] (1) leads, in solid state, to a dramatic decrease exchange magnetic coupling between copper(II) ions drastic change its powder EPR spectrum.
An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-<italic>a</italic>]pyridine was developed.