A5044942000- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Reactivity of Heterocycles
- Sesquiterpenes and Asteraceae Studies
- Synthesis of heterocyclic compounds
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Essential Oils and Antimicrobial Activity
- Synthesis and pharmacology of benzodiazepine derivatives
- Catalytic Cross-Coupling Reactions
- Organic Chemistry Synthesis Methods
- Traditional and Medicinal Uses of Annonaceae
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis and Reactions of Organic Compounds
- Asymmetric Synthesis and Catalysis
- Coordination Chemistry and Organometallics
- Plant Toxicity and Pharmacological Properties
- Marine Sponges and Natural Products
Université Hassan II Mohammedia
2015-2024
University of Hassan II Casablanca
2015-2023
École Normale Supérieure de l'Enseignement Technique de Mohammedia
2015-2021
Laboratoire de Chimie Physique
2015-2021
Université d'Orléans
2004-2019
University of Toronto
2019
Université de Montréal
2019
Kansas State University
2019
Département de Chimie Moléculaire
2017
Universities Research Association
2017
The design, synthesis, and screening of dual PI3K/mTOR inhibitors that gave nanomolar enzymatic cellular activities on both targets with an acceptable kinase selectivity profile are described. A docking study was performed to understand the binding mode compounds explain differences in biological activity. In addition, effects best were determined six cancer cell lines compared those a healthy diploid line for cytotoxicity. Two highly potent cells submicromolar range without any toxicity...
The development of CDK and GSK3 inhibitors has been regarded as a potential therapeutic approach, substantial number diverse structures have reported to inhibit CDKs GSK-3β in recent years. Only few molecules gone through or are currently undergoing clinical trials GSK inhibitors. In this paper, we prepared valmerins, new family containing the tetrahydropyrido[1,2-a]isoindone core. fused heterocycle was with straightforward synthesis that functionalized by (het)arylurea. Twelve valmerins...
3-iodo-1H-pyrrolo[3',2':4,5]imidazo-[1,2-a]pyridines and [1,2-b]pyridazines were prepared following Groebke-Blackburn-Bienaymé MCR combined with I2-promoted electrophilic cyclization. The flexibility of the method enables introduction diversity in 2, 5, 6, 7 positions on resulting scaffold using commercially available starting materials. Furthermore, subsequent palladium-catalyzed reactions successfully achieved our iodinated derivatives.
Industrial wastewaters cause severe environmental pollution, and in recent years, much work has been devoted to this topic searching less costly depollution methods.Several biomaterials have recently explored be used for the bio-sorption bio-coagulation-floculation of pollutants from wastewaters.In last there an advanced research regarding use biological materials wastewater treatment such as, chitosan, Moringaoleifera, algae, cactus plants etc.The main results obtained these studies oil...
Abstract The chemical composition of the three essential oils obtained by hydrodistillation resin, leaves and fruits Pistacia atlantica Desf. (Anacardiaceae) was studied GC GC/MS. Monoterpene hydrocarbons constituted main group in resin oil, with α-pinene (42.9%) β-pinene (13.2%) as major components. Oil contained high amounts oxygenated monoterpenes, bornyl acetate (21.5%) component, while monoterpenes sesquiterpenes were found to predominate oil among which terpinen-4-ol (21.7%) elemol...
A convenient and efficient synthetic route to C3-arylated 7-trifluoromethylpyrazolo[1,5-<italic>a</italic>]pyrimidin-5-one derivatives has been reported starting from 3-bromo-7-(trifluoromethyl)pyrazolo[1,5-<italic>a</italic>]pyrimidin-5-one through a Suzuki–Miyaura cross-coupling reaction.
Four novel and unusual C-19 compounds from Thapsia transtagana, named transtaganolides A−D, have been isolated. Their structures were established by physical methods, including X-ray analysis of A B. This is the first time that a 7-methoxy-4,5-dihydro-3H-oxepin-2-one ring has found in natural product.
Abstract Artemisia judaica L. essential oil was studied for antibacterial activity against various clinical isolates of bacteria resistant to a number antibiotics. The evaluated 20 multidrug (MDR) origin compared standard ATCC strains. strains that showed resistance the maximum antibiotics tested were selected an assay by three methods: Disc diffusion method, microatmosphere and dilution method. obtained results demonstrated A. possessed excellent inhibitory effect all most potent MRSA...
A series of novel enantiomerically pure spiro-(isoxazolidines/isoxazolines) were synthesized regioselectively by 1,3-dipolar cycloaddition using nitrones and nitrile oxides, on the exocyclic double bond tomentosin extracted from<italic>Dittrichia viscosa</italic>.
A simple and efficient method for synthesis of 5,7‐disubstituted pyrazolo[1,5‐ a ]pyrimidines is reported. The synthetic route involved first one‐pot two‐step 7‐substituted ]pyrimidin‐5‐ones from the reaction 3‐aminopyrazole 1 with activated alkynes. These compounds were used as key intermediates to access, excellent yields, library new ]pyrimidines, which are known their wide range biological activities, through C–O bond activation PyBroP (bromotripyrrolidinophosphonium hexafluorophosphate)...
The first access to dissymmetric 2,4-di(het)aryl-pyrido[3,2-d]pyrimidines III is reported. Two mild alternative routes led the rarely targeted compounds from 2,4-dichloro- and 2-chloro-4-isopropylsulfanyl-pyrido[3,2-d]pyrimidine by two successive palladium-catalyzed reactions involving an original regioselective chlorine discrimination. Alternatively, type were elaborated 2 C-2 further displacement of C-4 isopropylsulfanyl group, which acted as a temporary protecting group. These results...
Abstract The essential oils from leaves and wood of Tetraclinis articulata (Vahl) Masters Morocco were analyzed by GC GC/MS. main constituents the bornyl acetate (16.5%), camphor (19.1%) borneol (9.6%), while cedrol (28.2%) 1,7-di-epi-cedrol (17.9%) major components found in wood.