A5040451719- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Ferrocene Chemistry and Applications
- Bacterial biofilms and quorum sensing
- Synthesis and biological activity
- Microbial Metabolism and Applications
- Essential Oils and Antimicrobial Activity
- Lung Cancer Treatments and Mutations
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Copper-based nanomaterials and applications
- Pharmacological Effects of Natural Compounds
- Bone Tumor Diagnosis and Treatments
- Cytokine Signaling Pathways and Interactions
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- Antimicrobial agents and applications
- Insect Pest Control Strategies
- Plant Gene Expression Analysis
- Quinazolinone synthesis and applications
- ZnO doping and properties
- Synthesis of Organic Compounds
- Protein Kinase Regulation and GTPase Signaling
- Microbial bioremediation and biosurfactants
Centre of Biotechnology of Sfax
2016-2025
University of Sfax
2013-2024
Linköping University
2002-2006
Molina Center for Energy and the Environment
2005
Rosmarinus officinalis L. from Tunisia, popularly known as rosemary, is of a considerable importance for its medicinal uses and aromatic value. The aim this study was to examine the chemical composition essential oil (ROEO) evaluate antibiofilm activity on biofilm-forming bacterium anticancer cancer cell lines.The analyzed by GC-MS antibacterial evaluated micro-dilution method. antibofilm ROEO using crystal violet test cytotoxicity determined MTT assay.In research, thirty-six compounds were...
Bacterial contamination and biofilm formation generate severe problems in many fields.
Evaluation of the reactivity autoantibodies systemic lupus erythematosus (SLE) patients directed against malondialdehyde (MDA)-modified catalase, superoxide dismutase (SOD), and different Hep2 protein fractions (hydrophobic, hydrophilic, nuclear).Thiol groups MDA-protein adducts were first assessed among 65 SLE 60 healthy controls. Then, reactivities immunoglobulin (Ig)G towards MDA-modified unmodified proteins compared using a standard enzyme-linked immunosorbent assay (ELISA).An increase...
A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives was prepared using a one-pot three-component synthesis from 5-amino-1-phenyl-1H-1,2,4-triazoles, aromatic aldehydes and ethyl acetoacetate. The compound structures were confirmed by IR, 1H-NMR, 13C-NMR, HRMS X-ray analyses. biological activity these compounds as antitumor agents evaluated. Their activities against cancer cell lines (MDA-MB-231 MCF-7) tested the MTT in vitro method. Among them, 4c 4j displayed best with IC50 values...
ABSTRACT Biofilm formation and virulence factor production by Pseudomonas aeruginosa are identified as the main mechanisms of its antibiotic resistance pathogenicity. In this context, study chemical composition three Algerian essential oils (EOs) screening their antibacterial, antibiofilm, inhibitory activities enabled us to select thyme EO best oil control P. strain isolated from hospital environments. This EO, composed essentially thymol (55.82%) associated with carvacrol, had an...
In this study, biofilm formation and the production of key virulence factors were systematically evaluated across 33 strains Pseudomonas aeruginosa isolated from diverse hospital environments in Tunisia. Among these, 13 demonstrated strong biofilm-forming capacities. Adding glucose (9%, w/v) to culture medium generally enhanced development, indicating that supplementation may promote clinical isolates. The selected exhibited a consistent critical factors, including pyocyanin, rhamnolipid,...
<title>Abstract</title> The efficient conversion of copper nanoparticles (CuNPs) to oxide (CuO) is significant importance for applications in catalysis and antibacterial activity. While green synthesis methods CuO (CuONPs) have gained widespread attention, inconsistencies X-ray diffraction (XRD) profiles across studies suggest variations the final product's structural properties. This study conducts a comprehensive literature review 125 published articles compare XRD NPs produced...
Giant cell tumor of bone (GCTB) is generally considered a benign tumor, but it can exhibit locally aggressive behavior. The two main surgical treatment options for GCTB are intralesional curettage and en-bloc resection. This study examined the long-term recurrence rates among Tunisian patients after surgery. A including 36 diagnosed with was conducted. These underwent procedures, specifically in bloc Subsequently, we monitored these two-year post-operative period. Statistical analyses,...
Background Most fungal infections by opportunistic yeast pathogens such as Candida spp. are the major causes of morbidity in patients with lowered immune system and displayed a non- susceptibility to known antifungals. Objectives This study focuses on isolating species from non-candidiasis Iraqi at Tikrit Hospital assess predict potential risk developing candidiasis. Materials Methods In this 110 samples (vaginal oral) were collected hospital some other private clinic city. isolates...
Prodigiosin is a red pigment with pyrrolylpyrromethane skeleton. It mainly produced by bacterial strains belonging to the Serratia genus, but also some other genera, including Streptomyces and Vibrio . Within genus , generally as virulence factor. However, it has many important beneficial biological activities such immunosuppressive anti- proliferative activities. Moreover, industrial applications in textile cosmetics. In this mini-review, we discuss genetic molecular mechanisms supporting...
Abstract Herein we report the synthesis of ten newly substituted 3‐phenyl‐5‐aryl‐3,5‐dihydro‐4 H ‐benzo[6,7]chromeno[2,3‐ d ]pyrimidin‐4,6,11‐triones (“benzochromenopyrimidines”) in a one‐step reaction, by reacting ethyl 2‐amino‐4‐aryl‐5,10‐dioxo‐5,10‐dihydro‐4 ‐benzo[ g ]chromene‐3‐carboxylates with aniline, and triethyl orthoformate, under acidic catalyst solvent‐free conditions. These benzochromenopyrimidines were submitted to biological evaluation for vitro anti‐cancer activity, several...