A5029411824- Ferrocene Chemistry and Applications
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Phytochemicals and Antioxidant Activities
- Chemical Synthesis and Analysis
- Essential Oils and Antimicrobial Activity
- Edible Oils Quality and Analysis
- Sperm and Testicular Function
- Plant Disease Resistance and Genetics
- Synthesis of Organic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis of Indole Derivatives
- Biological Activity of Diterpenoids and Biflavonoids
- Chemical Synthesis and Reactions
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Telomeres, Telomerase, and Senescence
- Environmental Chemistry and Analysis
- Crystallography and molecular interactions
- Polyamine Metabolism and Applications
- DNA and Nucleic Acid Chemistry
- Nuts composition and effects
University of Sfax
2014-2025
Institut Supérieur de Biotechnologie de Sfax
2017-2025
Centre of Biotechnology of Sfax
2013-2024
Institut Supérieur des Biotechnologies de Paris
2017
Chimie ParisTech
2010-2014
Sorbonne Université
2010-2014
Centre National de la Recherche Scientifique
2010-2014
Georges Friedel Laboratory
2013
We have prepared several organometallic systems whose structures are closely analogous to that of tamoxifen, the drug used in treatment hormone-dependent breast cancers, but which now possess two basic aminoalkyl chains: O(CH2)3NMe2. Despite absence a phenolic functionality, these ferrocenyl compounds 3, 4 and their organic analogue 5 recognize estrogen receptor addition exhibit strong antiproliferative effects on cancer cells (MCF-7), also hormone-independent ones (MDA-MB-231) with, this...
The table olive industry produces a large amount of wastewater that can be expensive to treated and harmful the environment. This study aimed find way reuse brine water from production black green brines Bejaia Mascara Sigoise cultivar in order create valuable byproduct con-tribute sustainable development. In this context, high-performance liquid chromatography–diode-array detection (HPLC-DAD) analysis revealed highest concentration hydroxytyrosol (4-(2-dihydroxy phenyl ethanol); 69.67...
The chemical and sensory characteristics of virgin olive oil (VOO) extra (EVOO) are assessed in this study, with an emphasis on the relationships between profiles attributes such as fruitiness, bitterness, pungency, defect presence. To evaluate their composition qualities, 18 samples each type oil, primarily Chemlali cultivars from various Tunisian regions, were examined. According to analysis, VOO had a richer pigment profile than EVOO because it far higher chlorophyll carotenoid. As for...
Male infertility is one of the major health and social problems in Iraq. It can be caused by several factors, such as acquired, environmental, genetic factors. Awareness crucial role telomeres mitochondria sperm production fertility has increased recent years. This study aims to evaluate relationship between mitochondrial DNA (mtDNA) copy number telomere length degree Iraqi men. Of 200 participants, 50 were healthy controls 150 infertile. Sperm count, motility, morphology assessed collecting...
In order to explore the biological potential, some synthesized triazolylnucleosides were evaluated for their antibacterial, tyrosinase and DNA photocleavage activities. Triazolylnucleosides (5–12) screened against Staphylococcus aureus (ATCC 6538), gram-positive Escherichia coli 10536), gram-negative bacterial strains. Among series, compound 9 exhibited a significant level of antibacterial activity both strains at higher concentration in reference standard drug, Levofloxacin. Tyrosinase...
The crown gall induced in potato discs by Agrobacterium tumefaciens is becoming largely utilised screening anti-tumor agents. present work showing that beet are more adequate for the test. In fact, maximal tumor induction was observed on (87.5%), followed carrot (75%) and (68.5%). Beet most sensibility to disease with a fast expression of symptoms visible galls without any staining need. bioassay carried out using some synthesized organometallics known their antitumor activity mammalian...
Abstract In a previous work we have demonstrated the antimicrobial activity of ferrocenyl or phenyl derivatives diphenyl butene series. This finding has opened new area applications organometallic compounds. order to improve these activities, synthesized organic and diaryl compounds with different lengths their amino chains. These compounds, also ammonium salts, were tested against man pathogenic microorganisms Escherichia coli (ATCC 10536), Pseudomonas aeruginosa 15442), Staphylococcus...
The antiseptic and disinfectant potential of a formulation containing tamoxifen analogue was assessed according to European standards pharmacopeia in comparison with commercial product.
The inhibitory effects of four series aryl butene derivatives, active against breast cancer, on the monophenolase activity tyrosinase, in melanin-free ink from Sepia officinalis, have been studied. Hydroxytamoxifen 1, ferrociphenol 17 and several analogs shown strong antiproliferative hormone-dependent hormone-independent cancer cells were evaluated leukemia K562 cell proliferation. Their potential to induce skin depigmentation by evaluating their anti-tyrosinase was also estimated. In order...
Background: Tamoxifen citrate is a very prevalent drug marketed under several trade names like Apo-Tamox, Nolvadex, Tamec, Tamizam, and Tamoplex. This molecule approved by the FDA for breast cancer treatment. Some studies have shown that tamoxifen has anti-tuberculosis antiparasitic activities. Like any drug, possesses side effects, more or less dangerous. Aims: Basically, this work comparative study aims to: primarily compare antimicrobial antitumor activities of newly synthesized analog;...
Abstract The effluents derived from the processing of table olives stand for a serious environmental problem. study aims to valorize brine water at different stages ripening (green and black) Algerian variety Sigoise Bejaia (East) Mascara (West). physico‐chemical characterization revealed that these samples display have high acid pH salinity. comparative phenolic levels exhibited showed very significant differences between waters green Mascara, while brines black presented comparable levels....
The antibacterial activity of bisacodyl, a drug used in therapeutic as laxative, and its ferrocenyl analogues was investigated against Gram-positive Gram-negative foodborne pathogens including Listeria monocytogenes, Escherichia coli, Enterococcus faecalis, Salmonella enterica, Micrococcus luteus Staphylococcus aureus. results showed that most these compounds exhibit an excellent antimicrobial activity, the bisacodyl seemed to be more bactericides than bacteriostatic.
Abstract We observed for the first time crown gall symptoms in an orchard of olive trees (Olea europaea) variety ‘Chemlali’ – most widely grown cultivar Tunisia governorate Kairouan central Tunisia. Isolations from symptomatic tissues yielded bacteria that were identified as members species complex Agrobacterium tumefaciens using molecular techniques. The isolates then evaluated their pathogenicity by inoculating indicator plant Kalankoë daigremontiana. virulence three (O7, O9 and O11) was...
Background and aim: The global situation of bacterial diseases has become a concern in the last years due to lack new drugs antibiotic resistance. Since year 2000, only eight antibacterial molecules have obtained marketing authorization. Furthermore, despite discovery over twenty compounds with an interesting activity, few them belong chemical classes or required properties circumvent resistance problems. At present, order accelerate development relatively low costs reduced risks,...