A5066440492- Synthesis of Indole Derivatives
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Click Chemistry and Applications
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Synthesis of Organic Compounds
- Supramolecular Chemistry and Complexes
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Carbohydrate Chemistry and Synthesis
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- NF-κB Signaling Pathways
- Sulfur-Based Synthesis Techniques
- Asymmetric Synthesis and Catalysis
HESAM Université
2022-2024
University of Monastir
2017-2024
Conservatoire National des Arts et Métiers
2018-2024
Université Paris-Saclay
2024
Laboratoire de Chimie Moléculaire
2017-2024
Laboratoire de Chimie
2024
Université de Montpellier
2023
Centre National de la Recherche Scientifique
2023
École Nationale Supérieure de Chimie de Montpellier
2023
Institut des Biomolécules Max Mousseron
2023
The aza-Friedel–Crafts (aza-FC) reaction is a very powerful tool for forming C–C and C–N bonds, based on an acid-catalyzed addition of electron-rich aromatic compounds to imines.
Distinctive structural, chemical, and physical properties make the diarylmethane scaffold an essential constituent of many active biomolecules nowadays used in pharmaceutical, agrochemical, material sciences. In this work, 33 novel molecules aiming to target colorectal cancer were designed. Two series functionalized olefinic aryloxy diarylmethanes synthesized chemically characterized. The synthetic strategy involved a McMurry cross-coupling reaction as key step synthesis included O-arylation...
Triazolic TAM 9b, with its pronounced anticancer activity, highlight potential as a promising drug candidate for the treatment of colorectal cancer.
Background:: Nowadays, macrocyclic compounds constitute a privileged source for the development of with interesting biological properties. Ring-closing olefin me-tathesis has received great attention synthesis small, medium, and larger ring systems. Methods:: In present work, we described eight original pyridyl triarylmethanes using an efficient 3-step synthetic strategy. The bisalkylated 4,4'-(pyridin-X-ylmethylene) diphenols (X=2-4) were prepared by ring-closing metathesis as...
Here we report a macrocyclization route towards the synthesis of glycophane peptides by selective C-H arylation anomeric bond. This approach demonstrates power Pd-catalysis activation to access unfamiliar cyclic
Abstract Aiming to create an innovative series of anti‐colorectal cancer agents, we designed in this work hybrid triarylmethane compounds. Three triarylmethanes and their corresponding N ‐oxide analogues were successfully synthesized using efficient procedure that involved connecting two molecules, through mono‐, bi‐, triethylene glycol fragments. In our pursuit develop more soluble a featuring lysine‐based spacer convergent strategy involving 7 steps. All compounds assessed for...
Background and aim: The global situation of bacterial diseases has become a concern in the last years due to lack new drugs antibiotic resistance. Since year 2000, only eight antibacterial molecules have obtained marketing authorization. Furthermore, despite discovery over twenty compounds with an interesting activity, few them belong chemical classes or required properties circumvent resistance problems. At present, order accelerate development relatively low costs reduced risks,...
The process of drug discovery or lead optimization involves the efficient synthesis molecules and creation chemical libraries. For this reason, rapid generation new is essential. Originally defined by Professors Barry K. Sharpless M. G. Finn in 2001, Click chemistry a very powerful tool to develop set original, selective, modular building blocks such as azide alkyne small large scales. It type that allow synthesize complex an way. applications approach concern several domains discovery,...
Diarylmethanes (DAMs) and triarylmethanes (TAMs) are molecules with two or three aryl groups (phenyls heterocycles) bonded to a central carbon atom they have numerous applications. The biological therapeutic relevancy of this class been demonstrated in diverse areas such as antimicrobials, infectious, cardiovascular nervous system disorders, genital tract diseases, estrogen related disorders bone remodeling is quite well known. These interesting compounds also used starting materials for the...
In the present work, we described synthesis of eight original pyridyl macrocyclic triarylmethanes using an efficient 3-steps synthetic strategy. The bisalkylated 4,4'-(pyridin-X-ylmethylene) diphenols (X=2-4) were prepared by ring-closing metathesis, as macrocyclization key step, Grubbs second generation catalyst. obtained with moderate to good yields. introduction a pyridine N-oxide moiety before proved be interesting afford higher yield corresponding metathesis product. FT-IR, 1 H NMR, 13C...