A5037089281- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Family and Patient Care in Intensive Care Units
- Intensive Care Unit Cognitive Disorders
- Neonatal and Maternal Infections
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Escherichia coli research studies
- Trauma and Emergency Care Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Urinary Tract Infections Management
- Airway Management and Intubation Techniques
- Infective Endocarditis Diagnosis and Management
- Neonatal Respiratory Health Research
- Neonatal Health and Biochemistry
- Vasculitis and related conditions
- Pleural and Pulmonary Diseases
- Hemoglobinopathies and Related Disorders
- Bacterial biofilms and quorum sensing
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Cassava research and cyanide
Sorbonne Paris Cité
2017-2025
Université Paris Cité
2016-2025
Assistance Publique – Hôpitaux de Paris
2017-2025
Hôpital Robert-Debré
2017-2025
Inserm
2017-2025
Infection, Anti-microbiens, Modélisation, Evolution
2023
Délégation Paris 7
2017-2022
Délégation Paris 5
2016-2020
Hôpital Raymond-Poincaré
2020
Sorbonne Université
2018-2019
A recent increase in children admitted with hypotensive shock and fever the context of COVID-19 outbreak requires an urgent characterization assessment involvement SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers Paris all to pediatric intensive unit (PICU) shock, suspected infection between April 15th 27th, 2020.
Among 7578 cases of pediatric bacterial meningitis recorded in France (2001–2021), including 1313 neonatal cases, 23/7578 (0.3%) and 18/1313 (1.4%) were due to Citrobacter koseri. Median age was 11 days. About 63.6% patients hospitalized intensive care unit. Cerebral abscesses observed 77.8% the mortality rate 22.7%.
To describe the temporal dynamics, molecular characterization, clinical and ex vivo virulence of emerging O1:K1 neonatal meningitis Escherichia coli (NMEC) strains Sequence Type complex (STc) 95 in France. The national reference center collected NMEC performed whole genome sequencing (WGS) STc95 for phylogenetic genes content analysis. Data on biological features patients were also collected. Ex was assessed using Dictyostelium discoideum amoeba model. Among 250 between 1998 2015, 38...
Abstract Background Description and comparison of bacterial characteristics ventilator-associated pneumonia (VAP) between critically ill intensive care unit (ICU) patients with COVID-19-positive, COVID + ; non-COVID-19, COVID-. Methods Retrospective, observational, multicenter study that focused on French during the first wave pandemic (March–April 2020). Results 935 identification at least one bacteriologically proven VAP were included (including 802 +). Among Gram-positive bacteria, S....
Ventilator-associated pneumonia (VAP) is a severe intensive complication and remains under estimated in neonatal care unit (NICU). Center for Disease Control defined criteria adults pediatrics without criteria. The objective of this article was to evaluate the rate, risks factors outcome neonates suffering from ventilator-associated French NICU.We conducted prospective observational study within one-year period our NICU. Three hundred eighty-one 28 days age were included. Data analyses...
Mecillinam is recommended in France as a first-line treatment for lower urinary tract infections, due to the large increase resistance of Escherichia coli other oral treatments, such co-trimoxazole or fluoroquinolones, its limited impact on faecal microbiota and stability presence numerous β-lactamases. However, we recently identified several mecillinam-resistant E. isolates with high-level expression penicillinase (HEP) phenotype that merit further study.We studied two isogenic clinical...
Using whole-genome sequencing, we characterized Escherichia coli strains causing early-onset sepsis (EOS) in 32 neonatal cases from a 2019-2021 prospective multicenter study France and compared them to E. collected vaginal swab specimens women third-trimester gestation. We observed no major differences phylogenetic groups or virulence profiles between the 2 collections. However, sequence type (ST) analysis showed presence of 6/32 (19%) ST1193 EOS, same frequency as highly virulent clonal...
Sickle cell disease (SCD) is one of the most frequent inherited diseases in world. Over last decades, high-income countries, an important decrease mortality have been observed due to improvement care. However, children with SCD can become critically ill and require admission Pediatric Intensive Care Units (PICU). The purpose this study was describe epidemiology admitted PICU for acute crisis identify factors associated adverse outcome (AO).
Community-acquired and nosocomial lower-respiratory-tract infections in critically ill pediatric patients require early appropriate antibiotic therapy to optimize outcomes. Using blind bronchial samples, we assessed the diagnostic performance of rapid-multiplex polymerase chain reaction (PCR) assay BioFire Pneumonia plus Panel vs. reference standard culturing with antimicrobial susceptibility testing.
Abstract We report fatal meningitis in 2 neonates France caused by Shiga toxin 1–producing Escherichia coli. Virulence factors capsular K1 antigen and salmochelin were present both strains, potentially representing a new hybrid pathotype. Clinicians should remain aware of emerging pathotypes design therapeutic strategies for neonatal E. coli infections.
Escherichia coli (E. coli) is rarely implicated in bone or joint infections children. We discuss the case of a healthy 12-year-old girl with an E. bacteraemia and T11-T12 spondylodiscitis revealed by magnetic resonance imaging. The strain harboured serogroup O1:K1 virulence factors common to highly virulent extra intestinal pathogenic (ExPEC). Immunological work-up was normal. identification should lead search for immunosuppression host strain, particularly those ExPEC.
Introduction In children, respiratory distress due to upper airway obstruction (UAO) is a common complication of extubation. The quantitative cuff-leak test (qtCLT) simple, rapid and non-invasive that has not been extensively studied in children. objective the ongoing study whose protocol reported here investigate how well qtCLT predicts UAO-related postextubation paediatric intensive care unit (PICU) patients. Methods analysis Air Leak Test Paediatric Intensive Care Unit multicentre,...
We report a case of Staphylococcus aureus endocarditis, with large vegetation, in 17-month-old male infant, complicated meningitis, ischaemic strokes and osteoarthritis leading to haemorrhagic stroke by aneurysm rupture. He did not present any risk factor for endocarditis. The final course was favourable through, after valve replacement. strain sensible methicillin belongs complex clonal 398, accessory gene regulator I. found immunodeficiency.