Pierre Perez
A5103200169- Sepsis Diagnosis and Treatment
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Platelet Disorders and Treatments
- Hemodynamic Monitoring and Therapy
- Infective Endocarditis Diagnosis and Management
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Blood groups and transfusion
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Adenosine and Purinergic Signaling
- Nosocomial Infections in ICU
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
- Pericarditis and Cardiac Tamponade
- Pneumonia and Respiratory Infections
- 3D Shape Modeling and Analysis
- COVID-19 and healthcare impacts
Maison des Sciences de l’Homme de Dijon
2024
Université d'Angers
2023
Centre Hospitalier Régional et Universitaire de Nancy
2012-2023
Assistance Publique – Hôpitaux de Paris
2020-2023
Centre Hospitalier Universitaire d'Angers
2023
Pontifical Catholic University of Peru
2023
Université de Lorraine
2013-2021
McMaster University
2019
Centre de recherche Translationnelle en Médecine moléculaire
2018
Université de Bourgogne
2018
for the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH) IMPORTANCE Noninvasive ventilation has been recommended to decrease mortality among immunocompromised patients with hypoxemic acute respiratory failure.However, its effectiveness this indication remains unclear.OBJECTIVE To determine whether early noninvasive improved survival in nonhypercapnic failure.
Prone positioning may improve outcomes in patients with severe acute respiratory distress syndrome (ARDS), but it is unknown whether prone improves clinical among ARDS who are undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) compared supine positioning.
To assess long-term outcomes and the management of critical left-sided infective endocarditis (IE) evaluate impact surgery. Among 198 patients included prospectively for IE across 33 adult intensive care units (ICU) in France from 1 April 2007 to October 2008, 137 (69%) were dead at a median follow-up time 59.5 months. Characteristics significantly associated with mortality were: Sepsis-related Organ-Failure Assessment (SOFA) score ICU admission [Hazard ratio (HR), 95% Confidence Interval...
Autoimmune thrombotic thrombocytopenic purpura (TTP) can be associated with other autoimmune disorders, but their prevalence following TTP remains unknown. To assess the of disorders and to determine risk factors for time course development an disorder after a episode, we performed cross sectional study. Two-hundred sixty-one cases were included in French Reference Center registry between October, 2000 May, 2009. Clinical laboratory data available at diagnosis recovered. Each center was...
There are very few data regarding the effects of norepinephrine uptitration on global and regional hemodynamics in cardiogenic shock. We studied 25 patients with shock secondary to myocardial infarction successfully treated percutaneous coronary intervention. Before inclusion, 16 presented a cardiac arrest presence medical staff. Norepinephrine was titrated increase mean arterial pressure (MAP) from 65 85 mmHg during 1 h. Swan-Ganz variables, mixed venous blood gases, lactate, thenar...
Noninvasive diagnostic multiplex molecular tests may enable the early identification and treatment of viral infections in critically ill immunocompromised patients.To assess association between detection nasopharyngeal swabs ICU mortality hematology patients.This was a post hoc analysis prospective cohort patients admitted to 17 ICUs. Nasal sampled frozen at admission were tested using PCR assay. Predictors assay positivity identified.Of 747 (447 with acute respiratory failure [ARF]), 21.3%...
Abstract Background Both critically ill patients with coronavirus disease 2019 (COVID-19) and receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI). However, data on incidence, microbiology, resistance patterns, the impact HAI outcomes in ECMO for severe COVID-19 remain limited. We aimed to report microbiology evaluate ECMO-associated (ECMO-AI) in-hospital mortality. Methods For this study, we analyzed from 701...
We herein report the first case of Takotsubo cardiomyopathy triggered by influenza A virus. Myocardial involvement in virus infection has been described 10% cases. The literature principally reported cases acute myocarditis ranging from asymptomatic to fulminant heart failure and cardiac tamponade. frequently occurs setting significant emotional or physical stress medical illness, with a predominance postmenopausal women. diagnosis, management outcomes presented this case, aim describing new...
Venous thromboembolism is a major complication of coronavirus disease 2019 (COVID-19). We hypothesized that weight-adjusted intermediate dose anticoagulation may decrease the risk venous COVID-19 patients.In this multicenter, randomised, open-label, phase 4, superiority trial with blinded adjudication outcomes, we randomly assigned adult patients hospitalised in 20 French centers and presenting acute respiratory SARS-CoV-2. Eligible were (1:1 ratio) to receive an prophylactic or fixed-dose...
Thrombotic thrombocytopenic purpura (TTP) has a devastating prognosis without adapted management. Sources of misdiagnosis need to be identified avoid delayed treatment. We studied 84 patients with final diagnosis severe (<10%) acquired ADAMTS13 deficiency-associated TTP from our National database that included 423 patients, who had an initial (20% all TTP). Main diagnostic errors were attributed autoimmune thrombocytopenia, associated (51%) or not (37%) hemolytic anemia. At admission,...
Introduction . The PiCCO transpulmonary thermodilution technique provides two indices of cardiac systolic function, the function index (CFI) and global ejection fraction (GEF). Both appear to be correlated with left ventricular (LVEF) measured by echocardiography in patients circulatory failure, especially septic shock. aim present study was test reliability CFI as an indicator LVEF cardiogenic Methods In thirty-five shock, we performed (i) simultaneous measurements assessed (<mml:math...
Some patients with drug reaction eosinophilia and systemic symptoms (DRESS) are probably admitted in intensive care unit (ICU), but data concerning their clinical features at admission scarce. Therefore, the present study, we used a network of French intensivists to study evolution DRESS hospitalized ICU. A national, retrospective, multicenter collected cases ICU for from 2000 end 2011. All files were analyzed through RegiSCAR scoring system as "no," "possible," "probable," or "definite"...
The clinical profile and outcomes of patients with Coronavirus Disease 2019 (COVID-19) who require veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or veno-arterial-venous (VAV-ECMO) are poorly understood. We aimed to describe the characteristics these identify predictors both favourable unfavourable outcomes.ECMOSARS is a multicentre, prospective, nationwide French registry enrolling veno-venous (ECMO)/VA-ECMO in context COVID-19 infection (652 at 41 centres). focused on 47...
Introduction. Cardiac reserve could be defined as the spontaneous magnitude from basal to maximal cardiac power under stress conditions. The aim of this study was evaluate prognostic value parameters in resuscitated septic shock patients. Methods . Seventy patients with were included a prospective and observational study. Prior inclusion, reach mean arterial pressure 65–75 mmHg an euvolemic status. General, hemodynamic, reserve-related (cardiac index, double product, index) collected at...
Background The prevalence, prognostic role, and diagnostic value of blood pressure in immune-mediated thrombotic thrombocytopenic purpura (iTTP) other microangiopathies (TMAs) remain unclear. Methods Using a national cohort iTTP (n = 368), Shigatoxin-induced hemolytic uremic syndrome 86), atypical 84), hypertension-related microangiopathy 25), we sought to compare the cohort’s profile assess its impact on prognosis performances. Results Patients with had lower than patients TMAs, systolic...
Coagulation disorders increase mortality rate during septic shock, but the impact of concomitant hematological malignancies remains unknown. The study assessed coagulation in onco-hematological patients with thrombocytopenia (<100 G/L) admitted to ICU for shock. Among 146 included patients, 50 had lymphoma and 49 acute leukemia. was 43.8% (n = 64). Median prothrombin time (PT) at day(d) 1 4.7 s (IQR 3.2–7.9) survivors vs. 6.4 4.5–13.7; p < 0.01) non-survivors. Fibrinogen kinetics (increase...
The incidence of septic shock in intensive care France is around 8 to 10%, with in-hospital mortality ranging from 55 60% [1]. Mortality increases by 10% when the infection causing acquired or ICU We aimed determine predictive and prognostic factors for caused a nosocomial (NI).