Lina Khider
A5045915178- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Diagnosis and Treatment of Venous Diseases
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Photoacoustic and Ultrasonic Imaging
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Heparin-Induced Thrombocytopenia and Thrombosis
- Innovations in Medical Education
- Ultrasound Imaging and Elastography
- Central Venous Catheters and Hemodialysis
- Ultrasound and Hyperthermia Applications
- Blood Coagulation and Thrombosis Mechanisms
- Systemic Lupus Erythematosus Research
- Infectious Aortic and Vascular Conditions
- Sepsis Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic aneurysm repair treatments
- Otitis Media and Relapsing Polychondritis
Paris Cardiovascular Research Center
2018-2025
Université Paris Cité
2019-2025
Inserm
2018-2025
Hôpital Européen Georges-Pompidou
2019-2025
Assistance Publique – Hôpitaux de Paris
2019-2025
Sorbonne Paris Cité
2019-2024
Hôpital Européen
2019-2023
ESPCI Paris
2019-2022
Centre National de la Recherche Scientifique
2019-2022
Centre Hospitalier René-Dubos
2022
Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis. To explore endothelial damage activation-related biomarkers in COVID-19 patients criteria of hospitalization for referral to intensive care unit (ICU) and/or worsening. Analysis angiogenic soluble markers plasma from at admission. Study enrolled 40 consecutive admitted emergency department that fulfilled hospitalization. Half them were...
Abstract Rationale COVID-19 ARDS could differ from typical forms of the syndrome. Objective Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features respiratory failure. Our aim was to study pulmonary mechanics gas exchanges in COVID-2019 patients studied early after initiating protective invasive mechanical ventilation, seeking corresponding pathophysiological biological characteristics. Methods Between March 22 30, 2020 mechanics, exchanges,...
Abstract Background Microvascular, arterial and venous thrombotic events have been largely described during severe coronavirus disease 19 (COVID-19). However, mechanisms underlying hemostasis dysregulation remain unclear. Methods We explored two independent cross-sectional cohorts to identify soluble markers gene-expression signatures that discriminated COVID-19 severity outcomes. Results found elevated (s)P-selectin at admission was associated with severity. Elevated sP-selectin predictive...
In patients with venous thromboembolism at high risk of recurrence for whom extended treatment direct oral anticoagulants has been indicated, the optimal dose is unknown. We aimed to assess efficacy and safety reduced-dose versus full-dose in anticoagulation indicated. RENOVE was a non-inferiority, investigator-initiated, multicentre, randomised, open-label, blinded endpoint trial done 47 hospitals France. Ambulatory aged 18 years or older acute symptomatic (pulmonary embolism proximal deep...
Background Coronavirus disease 2019 (COVID‐19) is a respiratory associated with thrombotic outcomes coagulation and endothelial disorders. Based on that, several anticoagulation guidelines have been proposed. We aimed to determine whether therapy modifies the risk of developing severe COVID‐19. Methods Results Patients COVID‐19 initially admitted in medical wards 24 French hospitals were included prospectively from February 26 April 20, 2020. used Poisson regression model, Cox proportional...
Ultrasound localization microscopy (ULM) based on ultrafast ultrasound imaging of circulating microbubbles (MB) can image microvascular blood flows in vivo up to the micron scale. Takayasu arteritis (TA) has an increased vascularisation thickened arterial wall when active. We aimed perform vasa vasorum ULM carotid and demonstrate that provide markers assess TA activity.Patients with were consecutively included assessment activity by National Institute Health criteria: 5 had active (median...
Background: Coronavirus disease 2019 (COVID-19) has been associated with cardiovascular complications and coagulation disorders. Objectives: To explore clinical biological parameters of COVID-19 patients hospitalization criteria that could predict referral to intensive care unit (ICU). Methods: Analyzing the profiles at admission. Results: Among 99 consecutive fulfilled for hospitalization, 48 were hospitalized in medicine department, 21 first admitted ward department referred later ICU, 30...
Objective The clinical relevance of antiphospholipid antibodies (aPLs) in COVID‐19 is controversial. This study was undertaken to investigate the prevalence and prognostic value conventional nonconventional aPLs patients with COVID‐19. Methods a multicenter, prospective observational French cohort hospitalized suspected Results Two hundred forty‐nine were COVID‐19, whom confirmed 154 not 95. We found significant increase lupus anticoagulant (LAC) positivity among compared without (60.9%...
D‐dimer is a fragment of crosslinked fibrin resulting from plasmin cleavage clots and hence an indirect biomarker the hemostatic system activation. Early in coronavirus disease 2019 (COVID‐19) pandemic, several studies described coagulation disorders affected patients, including high levels. Consequently, has been widely used not‐yet‐approved indications. Ruling out pulmonary embolism deep vein thrombosis patients with low or intermediate clinical suspicion main application D‐dimer. also to...
Venous thromboembolism is a major complication of coronavirus disease 2019 (COVID-19). We hypothesized that weight-adjusted intermediate dose anticoagulation may decrease the risk venous COVID-19 patients.In this multicenter, randomised, open-label, phase 4, superiority trial with blinded adjudication outcomes, we randomly assigned adult patients hospitalised in 20 French centers and presenting acute respiratory SARS-CoV-2. Eligible were (1:1 ratio) to receive an prophylactic or fixed-dose...
Carotid plaque vulnerability assessment could guide the decision to perform endarterectomy. Ultrafast ultrasound imaging (UF) can evaluate local flow velocities over an entire 2D image, allowing measurement of wall shear stress (WSS). We aimed at evaluating feasibility WSS in a prospective series patients with carotid stenosis. UF acquisitions, performed linear probe, had effective frame rate 5000 Hz. The velocity was imaged area. computed vector field speed using formula: blood and μ,...
The increased interest in anti-platelet factor 4 (PF4)-heparin complex (anti-PF4/H) antibodies following the COVID-19 pandemic has established them as crucial players immunothrombosis. We aimed to investigate involvement of anti-PF4/H during and after vaccination, particularly patients with systemic inflammatory disease (SID). This retrospective study analyzed presence their ability induce platelet activation without suspected heparin-induced thrombocytopenia (HIT), vaccine-induced immune...
Abstract Isolated distal deep venous thrombosis (iDDVT) is an infra-popliteal DVT without pulmonary embolism (PE). It a common condition, but its management remains debated. We conducted survey distributed by email to the members of French Society Vascular Medicine, Thrombosis Canada, Swiss Angiology and INVENT-VTE research networks; Our objectives were determine how healthcare professionals specialized in manage iDDVT obtain experts input on design future clinical trial. Participants asked...