A5031835203- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Orthopedic Infections and Treatments
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Coronary Artery Anomalies
- Vasculitis and related conditions
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Structural Anomalies and Repair
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Function and Risk Factors
- Vascular anomalies and interventions
- MRI in cancer diagnosis
- Infectious Aortic and Vascular Conditions
- Acute Myocardial Infarction Research
- Parathyroid Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Atherosclerosis and Cardiovascular Diseases
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2015-2025
Hôpital Européen Georges-Pompidou
2020-2025
Université Paris Cité
2016-2025
Paris Cardiovascular Research Center
2020-2025
Hôpital Européen
2020-2025
William Harvey Research Institute
2022
Queen Mary University of London
2022
St Bartholomew's Hospital
2022
Laboratoire de Recherche Vasculaire Translationnelle
2016-2021
We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI vivo . There is a large clinical need for noninvasive tool atherosclerosis from molecular cellular standpoint. Macrophages play central role are associated with plaques vulnerable rupture. Therefore, macrophage scavenger receptor (MSR) was chosen as target MRI. MSR-targeted immunomicelles, micelles, gadolinium–diethyltriaminepentaacetic acid (DTPA) were tested ApoE−/−...
Cardiovascular diseases are the leading cause of death not only in Europe but also rest World. Preventive measures, however, often fail and cardiovascular disease may manifest as an acute coronary syndrome, stroke or even sudden after years silent progression. Thus, there is a considerable need for innovative diagnostic therapeutic approaches to improve quality care limit burden diseases. During past 10 years, several retrospective prospective clinical studies have been published using...
Echocardiography plays a key role in the diagnosis of infective endocarditis (IE) but can be inconclusive patients whom prosthetic valve (PVE) is suspected. The incremental diagnostic value <sup>18</sup>F-FDG PET and radiolabeled leukocyte scintigraphy IE has already been reported. aim this study was to compare respective performance for PVE 39 patients. <b>Methods:</b><sup>18</sup>F-FDG were performed on consecutive admitted because clinically suspected echocardiography results. results...
To prospectively determine whether early first-pass perfusion and delayed-enhancement magnetic resonance (MR) imaging sequences can enable differentiation of acute myocardial infarction (AMI) from myocarditis in patients with chest pain.All examinations were performed according to guidelines the institutional board on medical ethics clinical investigation after informed patient consent was obtained. Fifty-five a presentation suggestive but not typical AMI examined. At final diagnosis, 31 had...
Objective— Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease the Western world. This is because means of identifying truly vulnerable patients limited. Prediction atherosclerotic plaque rupture may be addressed by MRI activated matrix metalloproteinases (MMPs), a family enzymes that have been implicated vulnerability plaques prone rupture. study evaluated ability novel gadolinium-based contrast agent P947 target MMPs plaques....
The use of 18F-fluoro-deoxyglucose positron emission tomography scan (FDG-PET) and computed angiography (CTA) to improve accuracy diagnosis giant cell arteritis (GCA) is a very important clinical need. We aimed compare the diagnostic performance FDG-PET CTA in patients with GCA. were acquired all consecutive suspected for Results compared final based on judgment, temporal artery biopsy (TAB) findings, ACR criteria. Sensitivity, specificity, positive negative predictive values (PPV, NPV)...
The use of cardiac PET, and in particular quantitative myocardial perfusion has been growing during the last years, because scanners are becoming widely available several studies have convincingly demonstrated advantages this imaging approach. Therefore, there is a need determining procedural modalities for performing high-quality obtaining from demanding technique most terms both measurement reliability clinical data. Although field rapidly evolving, with progresses hardware software, near...
<sup>68</sup>Ga-pentixafor is a radiotracer for PET that binds with nanomolar affinity to CXCR4. The CXCR4 receptor expressed at the surface of inflammatory cells. objective study was analyze ability radiolabeled pentixafor detect expression on cells present in atherosclerotic plaques an experimental rabbit model. <b>Methods:</b> Atherosclerotic were induced by endothelial abrasion right carotid artery and abdominal aorta 7 rabbits fed atherogenic diet. Five noninjured chow diet used as...
18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been recently acknowledged as a diagnostic tool for prosthetic valve endocarditis, but its specificity is limited by uptake on noninfected valves. The objective of this study was to outline the main features FDG PET/CT in patients with heart (PHV).Our institution's database reviewed identify PHV, excluding those suspected infection or who had received antibiotic treatment. PET indication, location, and...
Abstract With this document, we provide a standard for PET/(diagnostic) CT imaging procedures in cardiovascular diseases that are inflammatory, infective, infiltrative, or associated with dysfunctional innervation (4Is). This should be applied clinical practice and integrated (multicenter) trials optimal procedural standardization. A major focus is put on using [ 18 F]FDG, but 4Is PET radiopharmaceuticals beyond F]FDG also described document. Whilst these novel tracers currently mainly early...
Abstract In daily clinical practice, clinicians integrate available data to ascertain the diagnostic and prognostic probability of a disease or outcome for their patients. For patients with suspected known cardiovascular disease, several anatomical functional imaging techniques are commonly performed aid this endeavor, including coronary computed tomography angiography (CCTA) nuclear cardiology imaging. Continuous improvement in positron emission (PET), single-photon (SPECT), CT hardware...
Abstract Background The prospective, multicentre EURECA registry assessed the use of imaging and adoption European Society Cardiology (ESC) Guidelines (GL) in patients with chronic coronary syndromes (CCS). Methods Between May 2019 March 2020, 5156 were recruited 73 centres from 24 ESC member countries. GL recommendations was evaluated according to clinical presentation pre-test probability (PTP) obstructive artery disease (CAD). Results mean age population 64 ± 11 years, 60% males, 42% had...
This document on cardiovascular infection, including infective endocarditis, is the first in American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess role radionuclide imaging multimodality context for evaluation complex systemic diseases with multi-societal involvement pertinent disciplines. A rigorous modified Delphi approach was used determine consensus clinical indications, diagnostic criteria, and an algorithmic diagnosis infection endocarditis....
The association of inflammatory cells and neovessels in atherosclerosis is considered a histological hallmark high-risk active lesions. Therefore, the development validation noninvasive imaging techniques that allow for detection inflammation neoangiogenesis would be major clinical interest. Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, quantify expressed as plaque content rabbit model...
Macrophages play a key role in atherosclerotic plaque rupture. The iodine-based contrast agent N1177 accumulates macrophages, allowing for their detection with CT. In this study, we tested whether the intensity of enhancement detected CT aortic wall rabbits injected correlated inflammatory activity evaluated <sup>18</sup>F-FDG PET/CT and macrophage density on histology. <b>Methods:</b> Atherosclerotic plaques were induced aorta New Zealand White (<i>n</i> = 7) by repeated balloon injury (4...
In patients with a suspicion of prosthetic valve endocarditis (PVE), detection perivalvular infection can be difficult based only on echocardiography. The aim this retrospective study was to test the interest radiolabelled leucocyte scintigraphy (LS) for in PVE and inconclusive transoesophageal echocardiography (TEE). LS performed 42 patients. results were classified as positive cardiac area (intense or mild), negative. Macroscopical aspects bacteriology obtained from who underwent surgery...