A5076364603- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- MRI in cancer diagnosis
- Protease and Inhibitor Mechanisms
- Acute Kidney Injury Research
- Radioactive element chemistry and processing
- Coronary Interventions and Diagnostics
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Imaging and Diagnostics
- Nitric Oxide and Endothelin Effects
- Biochemical effects in animals
- Cell Adhesion Molecules Research
- Electron Spin Resonance Studies
- Radiopharmaceutical Chemistry and Applications
- Cardiovascular Disease and Adiposity
- Heme Oxygenase-1 and Carbon Monoxide
- Photoreceptor and optogenetics research
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Sarcoidosis and Beryllium Toxicity Research
Guerbet (France)
2012-2022
Guerbet (United States)
2019-2022
Paris Cardiovascular Research Center
2010
Assistance Publique – Hôpitaux de Paris
2010
Hôpital Européen Georges-Pompidou
2010
Inserm
2008-2010
Cardiovascular Institute of the South
2008-2010
Icahn School of Medicine at Mount Sinai
2010
University of Mons
2009
Harvard University
1998-2008
Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification of hydrogen peroxide (H(2)O(2)) to water. In the present study we examined susceptibility mice with disruption glutathione gene neurotoxic effects malonate, 3-nitropropionic acid (3-NP), and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). knock-out showed no evidence neuropathological or behavioral abnormalities at 2-3 months age. Intrastriatal injections malonate resulted significant twofold...
Objective— Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease the Western world. This is because means of identifying truly vulnerable patients limited. Prediction atherosclerotic plaque rupture may be addressed by MRI activated matrix metalloproteinases (MMPs), a family enzymes that have been implicated vulnerability plaques prone rupture. study evaluated ability novel gadolinium-based contrast agent P947 target MMPs plaques....
Molecular and cellular imaging of atherosclerosis has garnered more interest at the beginning 21st century, with aims to image in vivo biological properties plaque lesions. Apoptosis seems an attractive target for diagnosis vulnerable atherosclerotic plaques prone a thrombotic event. The aim present work was screen apoptosis peptide binders by phage display final purpose detect apoptotic cells magnetic resonance (MRI). A phosphatidylserine-specific identified thus used design MRI contrast...
To evaluate the capability of P947, a magnetic resonance (MR) imaging contrast agent that molecularly targets matrix metalloproteinases (MMPs), to aid detection and MMPs in atherosclerotic lesions vivo; its specificity compared with P1135; expression distribution vessels; vivo molecular localization fluorescent europium (Eu) P947.The Animal Care Use Committee approved all experiments. P947 was synthesized by attaching gadolinium chelate...
P947 is a gadolinium-based magnetic resonance imaging (MRI) contrast agent with high affinity for several matrix metalloproteinases (MMPs) involved in arterial wall remodelling. We tested whether the intensity of enhancement detected vivo and MRI correlates actual tissue MMP-related enzymatic activity measured rabbit atherosclerotic model subjected to dietary manipulations. Aortas 15 rabbits which lesions were induced by balloon angioplasty 4 months hypercholesterolaemic diet imaged at...
To summarize the physicochemical characterization, pharmacokinetic behavior, and biological evaluation of P792, a new monogadolinated MRI blood-pool agent.The molecular modeling P792 was described. The r1 relaxivity properties were measured in water 4% human serum albumin at different magnetic fields (20, 40, 60 MHz). stability gadolinium complex assessed. biodistribution profiles studied rabbits. Renal tolerance dehydrated rats undergoing selective intrarenal injection evaluated....
Objective— Atherosclerotic plaque rupture leads to acute thrombus formation and may trigger serious clinical events such as myocardial infarction or stroke. Therefore, it would be valuable identify atherothrombosis vulnerable plaques before the onset of events. We sought determine whether noninvasive in vivo visualization activated platelets was effective when using a target-specific MRI contrast agent thrombi, hallmarks high-risk atherosclerotic plaques. Methods Results— Inflammatory...
Objective: Abdominal aortic aneurysm (AAA) rupture is a devastating event, and development of noninvasive methods to detect AAA at risk needed. Matrix metalloproteinases (MMPs) play major role in growth their subsequent rupture. This study was aimed evaluate the ability P947, recently developed magnetic resonance imaging (MRI) contrast agent, target MMPs vivo expanding experimental AAAs. Materials Methods: AAAs were induced Wistar rats (n = 18) by perfusion segment abdominal aorta with...
The vascular cell adhesion molecule-1 (VCAM-1) has distinct roles in inflammatory recruitment to the damaged vessel wall. In present work, a cyclic heptapeptide phage displayed library was screened vitro during four rounds of biopanning. On basis Kd and IC50 values, peptide (encoded as R832) selected for vivo validation. After conjugation Gd-DOTA, VCAM-1 imaging assessed by MRI on model T mediated hepatitis, induced mice concanavalin A. histological samples, location biotinylated R832...
Objective Some patients who received multiple administrations of gadolinium-based contrast agents (GBCAs) have been reported to develop “symptoms associated with gadolinium exposure” (SAGE). The aim this study was analyze pharmacovigilance data and explore the various SAGE patterns linear macrocyclic GBCAs among exhibiting 3 or more symptoms. Materials Methods were identified from a review scientific literature, corresponding preferred terms (PTs) searched in each system organ class recorded...
Previous work showed that several relatively specific inhibitors of neuronal nitric oxide synthase (nNOS) produce protection against MPTP induced dopaminergic toxicity. We examined whether a highly novel inhibitor nNOS, ARRI 7338, could also protect ARR17338 produced dose-dependent significant depletion dopamine and protected depletions tyrosine hydroxylase immunostained neurons in the substantia nigra. These results provide further evidence nNOS may be useful for treatment Parkinson's disease.
Inflammation within atherosclerotic lesions increases the risk for plaque rupture and thrombosis. A functional approach to analysis is intravenous administration of ultrasmall superparamagnetic particles iron oxide (USPIO) that enables visualization macrophages residing in plaques. In this study, we sought characterize age-related inflammatory status associated with atherosclerosis lesion progression ApoE mice using USPIO-enhanced magnetic resonance imaging (MRI).A total 24 were divided 4...
P947 (DOTA-Gd-peptide) was recently identified as an MRI contrast agent for the detection and characterization of matrix metalloproteinases (MMP)-rich atherosclerotic plaques. Because this product displays a broad spectrum affinity MMP family, we hypothesized that it may also recognize other overactivated in vulnerable Therefore, study aimed at describing, molecular cellular level, interactions between proteases Fluorimetric assays were used to measure vitro toward recombinant purified MMPs,...
The aim of the present study was to investigate effects four iodinated contrast media on cortical, inner medullary and outer blood flow in rat kidney by using laser-Doppler flowmetry. high-osmolar medium diatrizoate did not significantly modify perfusion but moderately decreased cortical when injected at a dose 1600 mg iodine kg(-1). Similar were obtained with low-osmolar ioxaglate iobitridol. In contrast, new iso-osmolar iodixanol induced dose-dependent reduction all regions tested. This...