A5066235616- Malaria Research and Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pregnancy and preeclampsia studies
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Immune cells in cancer
- Cystic Fibrosis Research Advances
- Reproductive System and Pregnancy
- Nitric Oxide and Endothelin Effects
- Parasites and Host Interactions
- Long-Term Effects of COVID-19
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Complement system in diseases
- HIV Research and Treatment
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
- Drug Transport and Resistance Mechanisms
- Neonatal Respiratory Health Research
- Advanced Electron Microscopy Techniques and Applications
- Moringa oleifera research and applications
- Cell death mechanisms and regulation
- Bacterial Infections and Vaccines
- Pregnancy and Medication Impact
- Advanced X-ray Imaging Techniques
University of Georgia
2012-2025
University of Abuja
2024
Georgia College & State University
2018
Institut Pasteur de Dakar
2006-2010
Hospital for Tropical Diseases
2009
Office of Infectious Diseases
2009
Centre National de la Recherche Scientifique
2006
Institut de Recherche pour le Développement
2006
Institut Pasteur
2006
Lactoperoxidase (LPO) is an enzyme found in several exocrine secretions including the airway surface liquid producing antimicrobial substances from mainly halide and pseudohalide substrates. Although innate immune function of LPO has been documented against microbes, a detailed characterization its mechanism action influenza viruses still missing. Our aim was to study antiviral effect substrate specificity inactivate using cell-free experimental system. Inactivation different virus strains...
Although an important role for excessive proinflammatory cytokines in compromise of pregnancy has been established, immunological basis malaria-induced fetal loss remains to be demonstrated. In this study, the roles IFN-gamma and TNF Plasmodium chabaudi AS-induced mice were directly investigated. Pregnant IFN-gamma(-/-) experienced a more severe course infection compared with intact C57BL/6 mice, characterized by high parasitemia, anemia, marked weight loss. However, was delayed these...
Abstract Background Neutrophils are key components of the exacerbated inflammation and tissue damage in cystic fibrosis (CF) airways. Neutrophil extracellular traps (NETs) trap kill pathogens. While NETs abundant airways CF patients have been hypothesized to contribute lung CF, vivo role remains controversial, partially due lack appropriate animal models. The goal this study was detect further characterize neutrophil-mediated mice overexpressing epithelial sodium channel (βENaC-Tg on C57BL/6...
Abstract Background Placental malaria is characterized by the accumulation of Plasmodium falciparum-infected erythrocytes and maternal inflammation in intervillous spaces placenta. These features are associated with placental damage fetal compromise. However, understanding mechanisms that lead to poor pregnancy outcome interventions targeting excessive host responses still lacking. The syncytiotrophoblast, a cell origin, known be responsive malaria-infected as well toxin, hemozoin, but its...
Low birth weight and fetal loss are commonly attributed to malaria in endemic areas, but the cellular molecular mechanisms that underlie these poor outcomes incompletely understood. Increasing evidence suggests dysregulated hemostasis is important pathogenesis, its role placental (PM), characterized by intervillous sequestration of Plasmodium falciparum, proinflammatory responses, excessive fibrin deposition not known. To address this question, markers coagulation fibrinolysis were assessed...
Significance Influenza infections kill millions of people worldwide. Current prophylactic treatment options are limited due to viral strain–specific vaccinations and emerging drug resistance. It is important discover new immune mechanisms that can fight the influenza virus. Our work presented here identifies such a mechanism. The Duox1 protein helps airways clear virus reduce infection-related death sickness in an animal model. delays infection process by directly targeting Unlike current...
Abstract Placental malaria, characterized by sequestration of Plasmodium falciparum in the maternal placental blood space and associated inflammatory damage, contributes to poor birth outcomes ∼200,000 infant deaths annually. Specific mechanisms that contribute damage dysfunction during malaria are not completely understood. To investigate a potential role for oxidative stress, antioxidant genes markers were assessed quantitative PCR immunohistochemistry chabaudi AS-infected pregnant mice....
The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on that artemisinin but also partner molecules. This study aims to evaluate the prevalence mutations in Pfdhfr, Pfdhps, and Pfmdr1 genes from isolates collected during a clinical study. Plasmodium genomic DNA samples extracted symptomatic malaria patients Dogondoutchi, Niger, were sequenced by Sanger method determine Pfdhfr (codons 51, 59, 108, 164), Pfdhps 436, 437, 540, 581, 613), 86, 184, 1034, 1246)...
The impact of placental malaria in African urban areas is poorly documented. We therefore conducted a study during the rainy season Dakar, an area with low transmission. Two groups delivering women were enrolled according to detection PfHRP2 blood. Ten percent positive for parasites placenta, and microscopic examination showed, respectively, 17%, 22%, 44% past, acute, chronic infection. mean birth weight decreased drastically infection placenta (2,684 ± 67 versus 3,085 66 g controls),...
Abstract Background Placental malaria (PM) is associated with poor foetal development, but the pathophysiological processes involved are poorly understood. Cyclooxygenase (COX) and lipoxygenase (LOX) which convert fatty acids to prostaglandins leukotrienes, play important roles in pregnancy development. COX-2, currently targeted by specific drugs, plays a dual role as it associates both pre-eclampsia pathology recovery during infection. The of COX PM was questioned quantifying at delivery...
Abstract Conventional pertussis animal models deliver hundreds of thousands Bordetella bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. However, human infections usually begin with colonization growth in upper respiratory tract. We inoculated only nasopharynx mice to explore course infection more natural exposure model. Nasopharyngeal resulted tract but elicited little response, enabling prolonged persistent infection. Immunization...
Malaria is still a major public health problem in Côte d'Ivoire. Both treatment and control there are hampered by the spread of resistance to common antimalarial drugs, especially south where multidrug-resistant malaria highly prevalent. Recent guidelines require vitro tests adaptation drug policies according local rates. In addition performing clinical assays field, we sought establish national map using with surveys. These make it possible detect changes susceptibility expected prevent...
Introduction Placental malaria (PM) is characterized by accumulation of inflammatory leukocytes in the placenta, leading to poor pregnancy outcomes. Understanding underlying mechanisms remains incomplete. Neutrophils respond parasites phagocytosis, generation oxidants, and externalization Neutrophil Extracellular Traps (NETs). NETs drive inflammation but evidence NETosis PM has not been reported. activity placenta directly investigated context PM/HIV-co-infection. Methods Using peripheral...
Seasonal influenza epidemics represent a significant global health threat. The exacerbated immune response triggered by respiratory virus infection causes severe pulmonary damage and contributes to substantial morbidity mortality. Regulator of G-protein signaling 10 (RGS10) belongs the RGS protein family that act as GTPase activating proteins for heterotrimeric G terminate pathways downstream protein-coupled receptors. While RGS10 is highly expressed in cells, particular monocytes...
Cystic fibrosis (CF) lung disease begins early in childhood and is characterized by neutrophilic inflammation of the airways. Neutrophil extracellular traps (NETs) represent one mechanism which neutrophils contribute to damage. The enzyme peptidylarginine deiminase 4 (PAD4) required for NET formation. Our overall concept that formation delivers PAD4 outside neutrophil resulting autoantibody generation, this autoimmunity may be a novel contributing CF progression. aim study was investigate...
Summary The molecular mechanisms that underlie poor birth outcomes in malaria during pregnancy remain poorly defined. To assess the role of host immune responses, mice known to respond differentially Plasmodium chabaudi AS infection were studied. Following at day 0 pregnancy, A/J developed significantly higher parasitemia than C57BL/6 (B6) and succumbed infection. Both strains had evidence parasite accumulation placenta mid‐gestation aborted, with embryo loss infected on 9. While...
Introduction Mycobacterium tuberculosis (Mtb) is the primary cause of human (TB) and currently second most common death due to a singleinfectious agent. The first line defense against airborne pathogens, including Mtb, respiratory epithelium. One innate defenses used by epithelial cells prevent microbial infection an oxidative antimicrobial system consisting proteins, lactoperoxidase (LPO) Dual oxidase 1 (Duox1), thiocyanate anion (SCN-) hydrogen peroxide (H2O2), which together lead...