A5051555745- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- T-cell and Retrovirus Studies
- Malaria Research and Control
- Global Maternal and Child Health
- Tuberculosis Research and Epidemiology
- Parasites and Host Interactions
- HIV/AIDS drug development and treatment
- Acute Lymphoblastic Leukemia research
- Child Nutrition and Water Access
- Autoimmune and Inflammatory Disorders Research
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Biochemical and Molecular Research
- Parvovirus B19 Infection Studies
- Glycosylation and Glycoproteins Research
- Tumors and Oncological Cases
- Genomic variations and chromosomal abnormalities
- Advanced Breast Cancer Therapies
- Cutaneous lymphoproliferative disorders research
Université de Thiès
2023-2025
World Health Organization
2023-2025
World Health Organization - Pakistan
2024
Centre National de la Recherche Scientifique
2018-2023
Cheikh Anta Diop University
2015-2023
Institut Gustave Roussy
2018-2023
Université Paris-Saclay
2019-2023
Hôpital Aristide Le Dantec
2015-2021
Université Paris-Sud
2018-2019
Abstract Background Only 63% of patients initiating multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment in 2020 were treated successfully. 24-Week all-oral bedaquiline, pretomanid, and linezolid (BPaL)–based regimens have demonstrated higher rates success been recommended by the World Health Organization. Operational research is urgently required to evaluate these non-trial settings. Methods This was a prospective cohort study with microbiologically confirmed...
Abstract Burkitt lymphoma (BL) is a B cell malignancy associated with the Epstein−Barr virus (EBV). Most BL cases are characterized by t(8;14) chromosomal translocation involving MYC oncogene and immunoglobulin heavy chain gene ( IGH ). The role of EBV in promoting this remains largely unknown. Here we provide experimental evidence that reactivation from latency leads to an increase proximity between loci, otherwise located far away nuclear space both B‐lymphoblastoid lines patients'...
Abstract A workshop on implementation strategies for the introduction of RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas highly seasonal transmission, was held as a hybrid meeting Dakar, Senegal, and online, 23–25 January 2023. Delegates from Expanded Programmes Immunization (EPI) National Malaria Control (NMCPs) 13 African countries, representatives key stakeholders participated. RTS,S is first to be recommended by World Health Organization (WHO). The recommendation followed...
Individuals infected with human immunodeficiency virus (HIV) are at increased risk for Burkitt lymphoma, a B-cell malignancy which occurs after chromosomal translocation rearranging the MYC oncogene an immunoglobulin gene locus, usually IGH heavy chain locus. We have previously reported that HIV protein Tat circulates in all HIV-positive individuals whatever their immune status caused rate of colocalization between and B-cells nuclei. here present vitro evidence activates expression AICDA...
Abstract Background This study aims to evaluate the effectiveness, safety, and impact on health-related quality of life (HQoL) a fully oral shortened regimen for Rifampicin-Resistant/Multidrug-Resistant Tuberculosis (RR/MDR-TB) over 9 12 months under programmatic conditions. Methods A prospective cohort was conducted an all-oral modified Shortened Treatment Regimen (mSTR) comprising linezolid (Lzd), bedaquiline (Bdq), levofloxacin (Lfx), clofazimine (Cfz), cycloserine (Cs). Patients with...
<title>Abstract</title> In Senegal, malaria is a seasonal disease predominantly concentrated in the southeast even before 2016. This study investigates relationship between weekly cases and meteorological factors four districts of Senegal (Kédougou, Sal´emata, Saraya, Dianké Makha). Using Generalized Additive Model (GAM), three techniques were tested to identify key variables. Data on sourced from DHSI2 data NASA GIOVANNI. Principal component analysis (PCA) was used most explanatory...
Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm characterized by the expansion of CD5-positive lymphocytes in peripheral blood. While CLL most common type Western populations, disease rare Africans. Hence, clinical and laboratory data studies Sub Saharan populations have been limited. The aims this study were to analyze characteristics senegalese patients with at time diagnosis identify correlation between (Binet stage) age, gender, parameters chromosomal abnormalities. In...
RDD (Rosai Dorfman disease) is a rare and benign histiocytic proliferative disorder of unknown etiology. FNAC (Fine-needle aspiration cytology) useful reliable tool for the diagnosis RDD, as such, biopsy avoidable.
Introduction: We assess the severity of rheumatoid arthritis in a Senegalese African black population. Patients and methods: It is retrospective study achieved service Internal Medicine Aristide Le Dantec teaching hospital Dakar between January 2005 December 2016 patients suffering from arthritis. specified for every patient predictive data Results: Four hundred three have been gathered (39 men 364 women), with mean age 45.8 years. An active tobacco addiction was noticed 10 patients. The...
We evaluated the relevance of using smudge cell percentage in blood smear as a prognostic marker CLL.In this prospective study, 42 untreated Senegalese patients with CLL were enrolled. The diagnosis was established, based on peripheral count and flow cytometry Matutes score. Cytogenetic aberrations, assessed by fluorescence situ hybridization (FISH), available for 30 patients, while immunoglobulin heavy chain genes (IGVH) mutation status performed next-generation sequencing (NGS) 24...
Integration of vertical programs for the control malaria, schistosomiasis, and soil-transmitted helminthiasis has been recommended to achieve elimination malaria neglected tropical diseases (NTD) by 2030. This qualitative study was conducted within context a randomized controlled trial explore perceptions views parents/caregivers at-risk children healthcare providers determine their acceptability integrated malaria-helminth treatment approach. Randomly selected enrolled in trial, providers,...
<title>Abstract</title> Background This study aims to evaluate the effectiveness, safety, and impact on health-related quality of life (HQoL) a fully oral shortened regimen for Rifampicin-Resistant/Multidrug-Resistant Tuberculosis (RR/MDR-TB) over 9 12 months under programmatic conditions. Methods A prospective cohort was conducted an all-oral modified Shortened Treatment Regimen (mSTR) comprising linezolid (Lzd), bedaquiline (Bdq), levofloxacin (Lfx), clofazimine (Cfz), cycloserine (Cs)....
Abstract Background The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for development an integrated control strategy that may help achieve elimination helminths. We conducted randomised, controlled, observer-blind trial assess feasibility safety combining mass drug administration (MDA) schistosomiasis soil transmitted (STH) with seasonal chemoprevention (SMC) among children living Senegal. Methods Female male aged 1–14 years were...
Abstract Background The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for development an integrated control strategy that may help achieve elimination helminths. A randomized, controlled, observer-blind trial was conducted assess feasibility safety combining mass drug administration (MDA) schistosomiasis soil transmitted (STH) with seasonal chemoprevention (SMC) among children living Senegal. Methods Female male aged 1–14 years were...
<h3>Background</h3> Integration of vertical programmes for the control malaria, schistosomiasis and soil-transmitted helminthiasis has been recommended to achieve elimination malaria neglected tropical diseases (NTD) by 2030. Given dearth studies on acceptability integrated approach, we conducted this qualitative study within context a randomized controlled trial explore perceptions views parents/caregivers at-risk children healthcare providers determine their malaria-helminth treatment...
Mantle cell lymphoma (
ABSTRACT Recurrent chromosomal translocations are found in many blood and solid cancers. Balanced translocations, frequent lymphoid malignancies, lead to the formation of two aberrant derivative (der) chromosomes. This event often leads overexpression an oncogene. In cases, expression oncogene is not enough produce a malignant phenotype; however, most part studies focus on events involving chromosome where located, but rarely other der oncogenic alterations may potentially arise. Mantle cell...