A5064321842- Viral Infections and Outbreaks Research
- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Disaster Response and Management
- Hepatitis B Virus Studies
- Poverty, Education, and Child Welfare
- Sex work and related issues
- Global Security and Public Health
- HIV/AIDS Impact and Responses
- Vaccine Coverage and Hesitancy
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Global Health and Surgery
- Ethics in Clinical Research
- Immune responses and vaccinations
- COVID-19 Impact on Reproduction
- Clinical Laboratory Practices and Quality Control
- Tuberculosis Research and Epidemiology
- Criminal Justice and Corrections Analysis
- Sexuality, Behavior, and Technology
- Global Health Care Issues
- Viral gastroenteritis research and epidemiology
- Pharmaceutical studies and practices
University of Liberia
2013-2024
Planned Parenthood Association of Liberia
2020-2024
University of Minnesota
2022
Bordeaux Population Health
2022
Université Claude Bernard Lyon 1
2022
Institut Bergonié
2022
University of Sierra Leone
2022
University of Maryland, Baltimore
2022
Hôpital Bichat-Claude-Bernard
2022
French Clinical Research Infrastructure Network
2022
The safety and efficacy of vaccines to prevent Ebola virus disease (EVD) were unknown when the incidence EVD was peaking in Liberia.We initiated a randomized, placebo-controlled, phase 3 trial chimpanzee adenovirus vaccine (ChAd3-EBO-Z) recombinant vesicular stomatitis (rVSV∆G-ZEBOV-GP) Liberia. A 2 subtrial embedded evaluate immunogenicity. Because declined Liberia, component expanded eliminated.A total 1500 adults underwent randomization followed for 12 months. median age participants 30...
The nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, included the World Health Organisation list of agents that should be prioritised for clinical evaluation patients with virus disease (EVD) during West African epidemic.In this single-arm phase 2 trial conducted Liberia, laboratory-confirmed EVD (two months age or older, enrolment bodyweight ≥50...
The index case of the Ebola virus disease epidemic in West Africa is believed to have originated Guinea. By June 2014, Guinea, Liberia, and Sierra Leone were midst a full-blown complex global health emergency. devastating effects this put response acute focus for urgent international interventions. Accordingly, October World Health Organization high-level meeting endorsed concept phase 2/3 clinical trial Liberia study vaccines. As follow-up response, November Government US signed an...
Questions remain concerning the rapidity of immune responses and durability safety vaccines used to prevent Zaire Ebola virus disease.
Novel oral poliovirus vaccine type 2 (nOPV2) was administered in Liberia response to an outbreak of circulating vaccine-derived (cVDPV2) 2021. We conducted a serological survey polio antibodies after two national campaigns with nOPV2.This clustered, cross-sectional, population-based seroprevalence children aged 0-59 months, more than 4 weeks the second nOPV2 vaccination round. used clustered sampling method four geographical regions Liberia, followed by simple random households. One eligible...
Establishment of immune correlates protection can provide a measurable criterion for assessing against infection or disease. For some vaccines, such as the measles vaccine, antibodies serve correlate protection, but others, human papillomavirus, remains unknown. Merck & Co, Kenilworth, NJ, USA, in collaboration with multiple partners, developed live recombinant vesicular stomatitis virus vaccine (rVSVΔG-ZEBOV-GP [ERVEBO]) containing Zaire ebolavirus glycoprotein (GP) place GP to prevent...
Background: Numerous epidemiological studies have documented that ulcerative sexually transmitted diseases (STDs), such as syphilis, chancroid, and genital herpes, promote heterosexual human immunodeficiency virus (HIV) transmission. However, the role of vaginal inflammations, Candida infection, in HIV acquisition has not been well established, even though, like Trichomona vaginalis it is rapidly emerging a significant co-factor Methods: This study was conducted among high-risk population...
Transactional sex (TS) has been correlated with HIV/STD infection, pregnancy, early marriage, and sexual violence in sub-Saharan Africa (SSA). Few Western-based HIV prevention programs adapted for SSA have examined intervention impacts this group. This article examines whether an intervention, delivered to sixth-grade students Liberia (age range 14-17) found increase condom use other mediators the larger sample, significantly impacted behaviors those who engaged TS. Using attention-matched,...
We conducted a randomized trial to address the health needs of in-school adolescents in Liberia, where we analyzed data from behavioral survey administered 820 students eight urban schools. Our findings suggest that are at significant risk for HIV and other sexually transmitted diseases (STDs): 36% respondents were experienced, 34% those had first sex ages 14 or younger, 66% sexual encounters unprotected, 16% described as “forced.” Also, females more likely have older boyfriends (Pearson's...
This paper presents findings of a feasibility study to adapt and evaluate the impact an evidence-based HIV prevention intervention on sexual risk behaviors in-school 6th grade youth in post-conflict Liberia (n = 812). The used attention-matched, group randomized controlled trial. Four matched pairs elementary/middle schools Monrovia, Liberia, were randomly assigned either adapted eight-module or general health curriculum. Three- nine-month impacts mediating variables are presented....
Liberia is a tropical country located south of the Sahara Desert in coastal West Africa. It lies at 6 °30' North Latitude and 9° 30' Longitude bordered by Guinea, Cote d'Ivoire, Sierra Leone Atlantic Ocean. has three distinct topographical areas: 1) plain, creeks, lagoons mangrove swamps; 2) rolling, forested hills with elevations up to 500 feet that cover most country; 3) low mountains plateaus Northern highlands reaching 4,748 (Nimba Mountains). home approximately four million people...
The purpose of this pilot project was to develop, administer and assess a brief male-focused behavioural-driven condom promotion programme for young adult African American males in an urban setting. To achieve the aims study, linkages with local community centres were initially fostered both quantitative qualitative research methods employed. Based on relevant tenets social cognitive theory stages change model, series focus groups conducted among target population, recruited from...
Liberia's prolonged post-conflict transition has negatively impacted its health infrastructure, including the functioning of care delivery system. Considering current national crises, a study was conducted to identify research gaps and need propose changes for improving system in country. The results clearly demonstrated lack HIV/AIDS infrastructure organizational structure, linkages, leadership, champions, expertise, resources, policies procedures. Alignment needs practice, use support...
This research study sought to develop, pilot test, and assess a brief male-centered condom promotion program for urban young adult African American males. For implementation, both qualitative quantitative methods were used, the project was guided by tenets of two common but integrated theoretical frameworks in HIV/sexually transmitted disease (STD) prevention research: social cognitive theory stages change model. The purpose component identify explore condom-use barriers facilitators while...
Micronutrient supplementation is recommended in Ebola Virus Disease (EVD) care; however, there limited data on its therapeutic effects. This retrospective cohort study included patients with EVD admitted to five Treatment Units (ETU) Sierra Leone and Liberia during September 2014 December 2015. A uniform protocol was used guide ETU care, due supply limitations, only a subset of received multivitamins. Data demographics, clinical characteristics, laboratory testing collected. The outcome...
Abstract Introduction The Ebola virus disease (EVD) outbreak in 2014–2016 West Africa was the largest on record and provided an opportunity for large clinical trials accelerated efforts to develop effective safe preventative vaccine. Multiple questions regarding safety, immunogenicity, efficacy of EVD vaccines remain unanswered. To address these gaps evidence base, Partnership Research Vaccines (PREVAC) trial designed. This paper describes design, methods, baseline results PREVAC discusses...
Abstract Rationale The prevention of human immunodeficiency virus/sexually transmitted diseases remains a significant global public health issue, especially among vulnerable populations. Aims and objectives To promote condom use skills young urban African American men. Methods As pilot study, randomized controlled trial was conducted 136 men aged 18–24 years recruited from communities in Chicago. Participants assigned to the intervention received 45–60 minutes one‐on‐one single‐session...
In November 2015, a 15-year-old boy received diagnosis of Ebola virus disease (EVD) at the John F. Kennedy Medical Center in Monrovia, Liberia. Two additional family members EVD. The protocol for phase 2 placebo-controlled trial vaccines was amended and approved; 4 days, single-arm cluster vaccination using Merck rVSVΔG-ZEBOV-GP vaccine initiated. Here, we evaluate safety immunogenicity discuss challenges its implementation small outbreak. We conducted ring study among contacts close EVD...