A5032599775- Cancer-related Molecular Pathways
- Mosquito-borne diseases and control
- Malaria Research and Control
- Chronic Myeloid Leukemia Treatments
- Glutathione Transferases and Polymorphisms
- Drug Transport and Resistance Mechanisms
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- HIV/AIDS drug development and treatment
- Physiological and biochemical adaptations
- Insect Pest Control Strategies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Animal Behavior and Reproduction
- Acute Lymphoblastic Leukemia research
- Hepatitis B Virus Studies
- Mental Health Treatment and Access
- Neurobiology and Insect Physiology Research
- HIV Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Pharmacogenetics and Drug Metabolism
- Chronic Lymphocytic Leukemia Research
Université des Sciences, des Techniques et des Technologies de Bamako
2014-2025
University of Bamako
2008-2025
Point University
2022
University of Hassan II Casablanca
2013-2021
Northwestern University
2020
Mali-Folkecenter
2020
The African malaria mosquito, Anopheles gambiae , inhabits diverse environments including dry savannas, where surface waters required for larval development are absent 4–8 months per year. Under such conditions, An. virtually disappears. Whether populations survive the long season by aestivation (a dormant state promoting extended longevity during summer) or reestablished migrants from distant locations sites persist has remained an enigma over 60 years. Resolving this question is important,...
Bioinformatics and data science research has boundless potential across Africa due to its high levels of genetic diversity disproportionate burden infectious diseases, including malaria, tuberculosis, HIV/AIDS, Ebola virus disease, Lassa fever. This work lays out an incremental training approach for engaging underserved populations in bioinformatics at the University Sciences, Techniques Technologies Bamako, Mali (USTTB). Two informatics programs sponsored by Fogarty International Center...
Objectives Breast cancer is the most prevalent and second leading cause of cancer-related deaths among women after cervical in much sub-Saharan Africa. This study aims to examine prevalence sociodemographic–socioeconomic factors associated with breast screening reproductive age Design A weighted population-based cross-sectional using Demographic Health Surveys (DHS) data. We used all available data on from DHS for four African countries (Burkina Faso, Ivory Coast, Kenya Namibia). was outcome...
Abstract Background Persistence of African anophelines throughout the long dry season (4-8 months) when no surface waters are available remains one enduring mysteries medical entomology. Recent studies demonstrated that aestivation (summer diapause) is mechanism allows malaria mosquito, Anopheles gambiae , to persist in Sahel. However, migration from distant localities - where reproduction continues year-round might also be involved. Methods To assess contribution aestivating adults buildup...
In the Sahel, Anopheles gambiae complex consists of arabiensis and M S molecular forms A. sensu stricto. However, composition these malaria vectors varies spatially temporally throughout region is thought to be linked environmental factors such as rainfall, larval site characteristics duration dry season. To examine possible physiological divergence between taxa, we measured metabolic rates mosquitoes during wet season in a Sahelian village Mali. our knowledge, this study provides first...
SUMMARY Malaria in Africa is vectored primarily by the Anopheles gambiae complex. Although mechanisms of population persistence during dry season are not yet known, targeting mosquitoes could provide opportunities for vector control. In Sahel, it appears likely that M-form A. survive aestivation (entering a dormant state). To assess role eco-physiological changes associated with survival, we measured body size, flight activity and metabolic rate wild-caught throughout 1 year Sahelian...
Les cancers associés aux infections (CAI) constituent une menace importante pour la santé publique dans les pays à revenu faible et intermédiaire (PRFI) comme le Mali, où taux d'infection sont très élevés. CAI représentent plus d'un quart (27%) de tous au Mali. Cependant, possibilités limitées formation étudiants, professeurs, chercheurs professionnels entravent recherche nécessaire développement nouvelles stratégies faire face tendances épidémiologiques actuelles. Le Centre Recherche...
Abstract Background: The metabolism of tamoxifen, used in breast cancer treatment, is influenced by the GSTT1 and GSTM1 genes. Women were classified as poor (inactivated genes), intermediate (reduced enzyme activity), or rapid (functional genes) metabolizers. This classification helped to understand how genetic variations affected treatment efficacy side effect risk, promoting a personalized therapeutic approach. study aimed analyze impact on tamoxifen Malian women with cancer. Methods: A...
Changes in spatial distribution of mosquitoes over time a Sahelian village were studied to understand the sources during dry season when no larval sites are found. At that time, Anopheles gambiae Giles may be local shelters used by aestivating or migrants from distant populations. The mosquito was more aggregated season, few houses had densities 7- 24-fold higher than expected. high-density differed those wet season. Most changed between years, yet their vicinity rather stable. Scan...
Mating in Anopheles gambiae has been observed only outdoor swarms. Here we evaluate whether mating also occurs indoors. Mark-release-recapture of virgin males and females natural houses showed that occurred over a single day even when mosquitoes can leave the house through exit traps without adaptation to laboratory conditions. In these experiments, insemination rate M molecular form An. (and arabiensis) was higher than S (15 versus 6%). Under conditions, smaller mated more frequently larger...
Reduced survival and future reproduction due to of current is a trade-off known as the cost reproduction. Surprisingly, only few studies have assessed in arthropod disease vectors, despite its effect on longevity, thus vectorial capacity. We evaluated Anopheles gambiae Giles by comparing mosquitoes that were denied exposure other sex, hereafter named virgins, those allowed sex mating, mated. Merely 6 d females with mating activity reduced male from median 17 virgins 15 mated, indicating...
Reduced survival and future reproduction due to of current is a trade-off known as the cost reproduction. Surprisingly, only few studies have assessed in arthropod disease vectors, despite its effect on longevity, thus vectorial capacity. We evaluated Anopheles gambiae Giles by comparing mosquitoes that were denied exposure other sex, hereafter named virgins, those allowed sex mating, mated. Merely 6 d females with mating activity reduced male from median 17 virgins 15 mated, indicating...
Abstract In arid environments, the source of malaria mosquito populations that re‐establish soon after first rains remains a puzzle and alternative explanations have been proposed. Using genetic data, we evaluated whether early rainy season ( RS ) population Anopheles coluzzii is descended from preceding late generation at same locality, consistent with dry DS dormancy (aestivation), or migrants distant locations. Distinct predictions derived these two hypotheses were assessed, based on...
Hypertension is a multifactorial disease caused by the interaction between genetic and environmental factors. Mutations in methylenetetrahydrofolate reductase gene (MTHFR) have been known to be associated with risk of cardiovascular as well hypertension. This case–control study was conducted out measure association polymorphism C677T MTHFR Polymerase chain reaction followed restriction fragment analysis length used identify genotypes patients 101 102 age sex matched healthy controls. Odds...
Abstract Metabolomic studies have demonstrated the existence of biological signatures in blood patients with arterial hypertension, but no study has hitherto reported sexual dimorphism these signatures. We compared plasma metabolomic profiles 28 individuals (13 women and 15 men) essential hypertension those a healthy control group (18 18 men), using targeted metabolomics. Among 188 metabolites explored, 152 were accurately measured. Supervised OPLS-DA (orthogonal partial least...
Chronic myeloid leukemia (CML), as most of cancers results from a complex interaction between genetic or non factors. Exposures to xenobiotics endogenous exogenous associated with reduced individual ability in detoxifying activity, constitutes risk developing cancer. It is known that polymorphism glutathione S-transferases (GSTs) genes affects the detoxification xenobiotics. Thus, we conducted case-control study which 92 patients (Mean age ± SD, 40.62 12.7 years) CML and 93 healthy unrelated...
The multidrug resistance gene (MDR1) plays an important role in the transport of a wide range drugs and elimination xenobiotics from body. Identification polymorphisms haplotypes MDR1 might not only help understand pharmacokinetics pharmacodynamics drugs, but also can prediction drug responses, toxicity, side effects, especially, era personalized medicine. We have analyzed genotypic haplotypic frequencies three most common single-nucleotide sample 100 unrelated healthy Moroccan subjects by...
Multidrug resistance gene 1 (MDR1) is known for its involvement in the detoxification through active transport of toxic compounds from diverse origins outside cells. These could cause injury to cell DNA, which might lead cancer like chronic myeloid leukemia (CML). Individual inherited genetic differences related polymorphism enzymes be an important factor not only carcinogen metabolism but also susceptibility cancer. The present study aimed investigate association three single nucleotide...