A5100367720- Catalytic C–H Functionalization Methods
- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Radical Photochemical Reactions
- Advanced Synthetic Organic Chemistry
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Microbial Natural Products and Biosynthesis
- Alkaloids: synthesis and pharmacology
- Synthesis of Indole Derivatives
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Cancer-related gene regulation
- Cyclopropane Reaction Mechanisms
- Catalytic Cross-Coupling Reactions
- Peptidase Inhibition and Analysis
- Traditional and Medicinal Uses of Annonaceae
- Catalytic Alkyne Reactions
- Synthesis and Characterization of Pyrroles
- Bacterial Infections and Vaccines
- RNA modifications and cancer
Lanzhou University
2013-2025
Lanzhou Veterinary Research Institute
2022-2025
Chinese Academy of Agricultural Sciences
2024-2025
China Earthquake Administration
2024-2025
State Key Laboratory of Applied Organic Chemistry
2021-2024
Nankai University
2024
Hangzhou First People's Hospital
2022
Zhejiang University
2022
Zhejiang Chinese Medical University
2022
Shenyang University of Technology
2022
Cycloaddition is an essential tool in chemical synthesis. Instead of using light or heat as a driving force, marine sponges promote cycloaddition with more versatile but poorly understood mechanism producing pyrrole-imidazole alkaloids sceptrin, massadine, and ageliferin. Through de novo synthesis sceptrin we show that may use single-electron oxidation central to three different types cycloaddition. Additionally, provide surprising evidence that, contrast previous reports, ageliferin have...
Porcupine is a member of the membrane-bound O-acyltransferase family proteins. It catalyzes palmitoylation Wnt proteins, process required for their secretion and activity. We recently disclosed class small molecules (IWPs) as first reported Porcn inhibitors. now describe structure–activity relationship studies identification subnanomolar also report herein effects IWPs on Wnt-dependent developmental processes, including zebrafish posterior axis formation kidney tubule formation.
Simple and cheap alcohols can promote the direct arylation of unactivated arenes with aryl iodides bromides in presence potassium tert-butoxide. This transition-metal-free aromatic C–H transformation offers a easy practical way to synthesize biaryls under mild conditions.
A platinum-catalyzed tandem reaction involving enynyl ester isomerization and subsequent intramolecular [3 + 2] cyclization has been developed. This strategy provides an efficient approach to five-, six-, or seven-membered cyclic polyfunctional compounds.
This report describes palladium-catalyzed C-H glycosylation and retro Diels-Alder tandem reaction via structurally modified norbornadienes (smNBDs). smNBDs were proposed to regulate the reactivity of aryl-norbornadiene-palladacycle (ANP), including its high chemoselectivity regioselectivity, which key constructing C2 C3 unsubstituted C4-glycosidic indoles. The scope this substrate is extensive; halogenated six-membered five-membered glycosides applied smoothly, N-alkyl (primary, secondary...
A novel photocatalyst-free visible-light-mediated dithioacetalization of aldehydes and thiols has been developed.
The pyrrole-imidazole alkaloids have fascinated chemists for decades because of their unique structures. high nitrogen and halogen contents the densely functionalized skeletons make laboratory synthesis challenging. We describe herein an oxidative method accessing core two classes dimers. This synthetic strategy was inspired by putative biosynthesis pathways its development facilitated computational studies. Using this method, we successfully prepared ageliferin, bromoageliferin,...
A strategy for the synthesis of multisubstituted hydrocarbazoles has been developed through (3 + 2)-annulation p-quinamines and arynes. In this way, new analogs with quaternary carbon center can be synthesized in satisfactory yield under mild conditions. Furthermore, easily scaled-up, products modified simple transformation.
Open AccessCCS ChemistryRESEARCH ARTICLE7 Nov 2022Enzyme-like C–H Oxidation of Glucosides Promoted by Visible Light Mingzhong Wu, Qian Jiang, Qiong Tian, Tianyun Guo, Feng Cai, Shouchu Tang, Jian Liu and Xiaolei Wang Wu State Key Laboratory Applied Organic Chemistry, Department Chemistry School Pharmacy, Lanzhou University, 730000 , Jiang Tian Veterinary Etiological Biology, OIE/National Foot Mouth Disease Reference Laboratory, Guo Cai The National Glycoengineering Research Center, Shandong...
Concise and efficient asymmetric total syntheses of three substituted α-pyrone-type natural products have been accomplished via 7−9 steps from 5b in high overall yields, which involve linchpin coupling, ring-closing metathesis, a tandem sequence deacetylation intramolecular oxa-Michael addition as the key steps.
The development of a visible-light mediated bromo radical addition/spirocyclization/ester migration cascade reaction to generate 3-bromocoumarins from alkynoates is reported.
Abstract A series of compounds bearing quinoline‐imidazole ( 8a–e , 9a–e 10a–e 11a–e and 12a–e ) not reported previously were designed synthesized. The target evaluated for antitumor activity against A549, PC‐3, HepG2, MCF‐7 cells by the MTT method, with NVP‐BEZ235 being positive control. Most showed moderate compound 12a best PC‐3 cells, half‐maximal inhibitory concentration (IC 50 values 2.42 ± 1.02 µM, 6.29 0.99 5.11 1.00 respectively, which was equal to (0.54 0.13 0.36 0.06 0.20 0.01...
The first total synthesis of Gardneria oxindole alkaloid (−)-gardmultimine A has been achieved in 19 steps from d-tryptophan a fully stereocontrolled manner. This features (1) an Ir-catalyzed regioselective C–H borylation/oxidation sequence to introduce the C12 methoxyl group, (2) oxidative rearrangement indole construct spirooxindole motif, and (3) Au(I)-catalyzed transannular Conia-ene-type 6-exo-dig cyclization establish azabicyclo[2.2.2]octane skeleton exocyclic E-alkene with exclusive...
Klebsiella pneumoniae found in the normal flora of human oral and intestinal tract mainly causes hospital-acquired infections but can also cause community-acquired infections. To date, most clinical trials vaccines against K. have ended failure. Furthermore, no single conserved protein has been identified as an antigen candidate to accelerate vaccine development. In this study, we five outer membrane proteins , namely, Kpn_Omp001, Kpn_Omp002, Kpn_Omp003, Kpn_Omp004, Kpn_Omp005, by using...
Adjuvants are crucial agents that enhance the immunogenicity of vaccines, with QS-21 being particularly noteworthy for its potent immunostimulatory properties. QS-21, a saponin-based vaccine adjuvant isolated from bark Quillaja saponaria, has garnered significant attention. However, application as is limited due to scarcity, complex chemical synthesis, and inherent toxicity. This study aims develop analogues simplified structures, enhanced immunogenicity, reduced Our research findings...
Here we present a regio- and stereoselective alkylation approach for unprotected saccharides using synergistic boronic acid photoredox catalysis. Targeting the equatorial C-H bond of cis-1,2-diol motif, this method employs MeB(OH)2 as catalyst. Mechanistic investigations indicate that formation tetracoordinate boron species, resulting from interaction between cyclic diol ester free hydroxyl group in saccharide, is critical to transformation. Notably, enables efficient late-stage modification...
A modular total synthesis of A201E and its analogues is modeled after the previously reported biosynthetic pathway. The challenging task obtaining 1,2-cis-furanoside, a vital core structure analogues, was accomplished through strategic use remote 2-quinolinecarbonyl-assisted glycosylation. From this pivotal 1,2-cis-furanoside moiety, we successfully completed analogues. Guided by principles medicinal chemistry, evaluated antimicrobial activities A201A/E comprehensive assessment their has...
In the field of space gravitational wave detection, high-precision temperature measurement with a resolution at micro-Kelvin level in milli-Hertz frequency range is required to mitigate interference caused by fluctuations around core components. This very challenging task due resistance thermal noise and inherent 1/f electronic To overcome this problem, paper proposes low-noise, high-resolution method based on an inductive voltage divider alternating-current (AC) bridge. The proposed has...