A5100414694- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Mass Spectrometry Techniques and Applications
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Molecular Sensors and Ion Detection
- Proteoglycans and glycosaminoglycans research
- Click Chemistry and Applications
- Analytical chemistry methods development
- Synthesis and Catalytic Reactions
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Reactions
- Analytical Methods in Pharmaceuticals
- Radical Photochemical Reactions
- Advanced Proteomics Techniques and Applications
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Ion-surface interactions and analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Microfluidic and Capillary Electrophoresis Applications
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Synthesis of Indole Derivatives
Lanzhou University
2013-2025
Jiangxi Normal University
2021-2024
Heze University
2022-2024
Changchun Institute of Applied Chemistry
2023
Chinese Academy of Sciences
2023
University of Science and Technology of China
2023
Soochow University
2023
Northwestern University
2023
Shandong Normal University
2022
Lanzhou University of Technology
2020
A Ni(0)-catalyzed intermolecular cross-coupling of various functionalized thiols and aryl iodides has been developed successfully extended to less explored intramolecular versions, where thioacetates could also be utilized as the strategic surrogate. Air-stable precatalysts, very mild conditions, an easy protocol allow rapid access medicinally useful thioethers, demonstrated in facile synthesis (±)-chuangxinmycin a key step.
A commercial quadrupole/time-of-flight (QqTOF) tandem mass spectrometer has been adapted for ion/ion reaction studies. To enable mutual storage of oppositely charged ions in a linear ion trap, the oscillating quadrupole field second system (Q2) serves to store radial dimension while auxiliary radio frequency is superposed on end lenses Q2 during period create barriers axial dimension. pulsed dual electrospray (ESI) source directly coupled instrument interface purpose proton transfer...
The organelle-specific pH is crucial for cell homeostasis. Aberrant of lysosomes has been manifested in myriad diseases. To probe lysosome responses to stress, we herein report the detection lysosomal changes with a dual colored (CM-ROX), featuring coumarin domain "always-on" blue fluorescence and rhodamine–lactam activatable acidity give red fluorescence. With sensitive ratiometric signals upon subtle changes, CM-ROX enables discernment cells undergoing autophagy, death, viral infection.
Eight N-acetylglucosamine-1-phosphate and N-acetylgalactosamine-1-phosphate analogs have been synthesized chemically were tested for their recognition by the GlmU uridyltransferase enzyme. Among these, only substrates that an amide linkage to C-2 nitrogen transferred afford corresponding uridine diphosphate(UDP)-sugar nucleotides. Resin-immobilized showed comparable activity nonimmobilized provides a more facile final step in synthesis of unnatural UDP-donor. The UDP-donors as...
Two new Schiff base fluorescent probes (L and S) were designed for selectively detecting Al3+ ions in aqueous medium. Structural characterization of the purely synthesized compounds was acquired by IR, 1H NMR 13C NMR. Moreover, their photochromic behaviors have been investigated systematically UV-Vis absorption fluorescence spectra. The two both high selectivity sensitivity toward 2:1 stoichiometry between verified Job's plot. limits detection (LOD) L S 1.98 × 10-8 4.79 mol/L, respectively,...
Glycosylation of natural products, including antibiotics, often plays an important role in determining their physical properties and biological activity, thus potential as drug candidates. The arylomycin class antibiotics inhibits bacterial type I signal peptidase is comprised three related series products with a lipopeptide tail attached to core macrocycle. Previously, we reported the total synthesis several A derivatives, which have unmodified macrocycles, well B nitrated We now report...
A hetero-organelle partition and lysosome activable sensor was developed for fluorogenic detection of mitochondrial depolarization in autophagy cell death.
Abstract Pd‐catalyzed chemistry has played a significant role in the growing subfield of bioorthogonal catalysis. However, rationally designing Pd nanocatalysts that show outstanding catalytic activity and good biocompatibility poses great challenge. Herein, we propose an innovative strategy through exploiting black phosphorous nanosheets (BPNSs) to enhance Pd‐mediated activity. Firstly, electron‐donor properties BPNSs enable situ growth nanoparticles (PdNPs) on it. Meanwhile, due superb...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTElucidation of Transition Structures and Solvent Effects for Epoxidation by DimethyldioxiraneCorky Jenson, Jian Liu, Kendall N. Houk, William L. JorgensenView Author Information Department Chemistry, Yale University New Haven, Connecticut 06520-8107 Chemistry Biochemistry California Los Angeles, 90095 Cite this: J. Am. Chem. Soc. 1997, 119, 52, 12982–12983Publication Date (Web):December 31, 1997Publication History Received29 May 1997Revised12...
A new three-dimensional (3D) mesoporous hybrid framework was synthesized by coordinated layer-by-layer assembly between nanosheets of reduced graphene oxide and Fe3O4@Cu2O. This 3D shows an excellent catalytic performance with a remarkable activity, selectivity (>99%), strong durability in the synthesis quinoxalines.
Late-stage diversification of structurally complex peptides has enormous potential for drug discovery and molecular imaging. We report a simple, metal-free, late-stage reductive C2 alkylation tryptophan tryptophan-containing using readily available 1,3-dithianes. This protocol wide substrate scope an excellent tolerance reactive functional groups.
Fe(3)O(4) nanoparticles (NPs) decorated with rhodamine 6G Schiff base, which exhibit high selectivity and sensitivity toward Al(3+) over other common metal ions in aqueous media under a physiological pH window via 1:1 binding mode, have been synthesized characterized. The resulting conjugate renders the base unit more water soluble, detection limit reaches 0.3 ppb water. Moreover, can detect wide span (5.0-11.0) enrich/remove excess an external magnetic field, indicates that it has potential...
Here we present a regio- and stereoselective alkylation approach for unprotected saccharides using synergistic boronic acid photoredox catalysis. Targeting the equatorial C-H bond of cis-1,2-diol motif, this method employs MeB(OH)2 as catalyst. Mechanistic investigations indicate that formation tetracoordinate boron species, resulting from interaction between cyclic diol ester free hydroxyl group in saccharide, is critical to transformation. Notably, enables efficient late-stage modification...