A5025166909- Acute Ischemic Stroke Management
- Platelet Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Barrier Structure and Function Studies
- S100 Proteins and Annexins
- Neurogenesis and neuroplasticity mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Cell Adhesion Molecules Research
- Nutritional Studies and Diet
- Apelin-related biomedical research
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Planarian Biology and Electrostimulation
- GDF15 and Related Biomarkers
- Cardiovascular Function and Risk Factors
- Complement system in diseases
- Blood Pressure and Hypertension Studies
- Cellular transport and secretion
- Ferroptosis and cancer prognosis
Fudan University
2015-2024
State Key Laboratory of Medical Neurobiology
2013-2024
Qinghai Tibetan Hospital
2020
Shanghai Medical College of Fudan University
2012-2016
Fujian Medical University
2015
GTx (United States)
2015
Shanghai Jiao Tong University
2015
Shanghai Sixth People's Hospital
2015
Hamamatsu University
2004-2005
Hamamatsu University School of Medicine
2000-2004
Neovascularization and vascular remodeling are functionally important for brain repair after stroke. We show that neutrophils accumulate in the peri-infarct cortex during all stages of ischemic Neutrophils producing intravascular intraparenchymal neutrophil extracellular traps (NETs) peak at 3-5 days. Neutrophil depletion reduces blood-brain barrier (BBB) breakdown enhances neovascularization 14 Peptidylarginine deiminase 4 (PAD4), an enzyme essential NET formation, is upregulated...
Abstract Intracerebral hemorrhage associated with thrombolytic therapy tissue plasminogen activator (tPA) in acute ischemic stroke continues to present a major clinical problem. Here, we report that infusion of tPA resulted significant increase markers neutrophil extracellular traps (NETs) the cortex and plasma mice subjected photothrombotic middle cerebral artery occlusion. Peptidylarginine deiminase 4 (PAD4), critical enzyme for NET formation, is also significantly upregulated brains...
Blood–brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key, mainly deleterious role in pathophysiology of ischemic stroke. Neddylation is ubiquitylation-like pathway that critical various cellular functions by conjugating neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) to target proteins. However, roles neddylation stroke remain elusive. Here, we report NEDD8 conjugation increased during acute phase after was present intravascular...
Stroke is a leading cause of long-lasting disability in humans. However, currently there are still no effective therapies available for promoting stroke recovery. Recent studies have shown that the adult brain has capacity to regenerate neurons after stroke. Although this neurogenic response may be functionally important repair injury, mechanisms underlying stroke-induced neurogenesis not known. Caspase-3 major executioner and been identified as key mediator neuronal death acute stage...
Tissue plasminogen activator (tPA) is approved for treatment of acute ischemic stroke, but it increases the risk cerebral hemorrhage. Accumulating evidence suggests that von Willebrand factor (VWF) plays a pivotal role in thrombus formation and microcirculatory disturbances after stroke. By cleaving VWF, ADAMTS13 (a disintegrin metalloproteinase with thrombospondin type 1 motif, member 13) protects mice from Therefore, we hypothesized recombinant (rADAMTS13) could increase safety tPA...
Background: Growth differentiation factor 11 (GDF11), a member of transforming growth factor-β (TGF-β) superfamily, was shown to rejuvenate cardiac and skeletal muscle function improve cerebral vasculature neurogenesis in old mice. However, recent experimental data reported that raising GDF11 levels inhibited regeneration had no effect on hypertrophy. Our aim investigate the effects brain repair during recovery phase after stroke. Methods: Mice were subjected distal middle artery occlusion,...
Inflammatory responses and blood-brain barrier (BBB) dysfunction play important roles in brain injury after intracerebral hemorrhage (ICH). The metalloprotease ADAMTS 13 (a disintegrin with thrombospondin type I motif, member 13) was shown to limit inflammatory through its proteolytic effects on von Willebrand factor. In the present study, we addressed role of experimental ICH.ICH induced mice by infusion autologous blood. peri-hematomal responses, levels matrix metalloproteinase-9...
Abstract Spontaneous intracerebral haemorrhage (ICH) is the most devastating stroke subtype and has no proven treatment. von Willebrand factor (VWF) recently been demonstrated to promote inflammation processes. The present study investigated pathophysiological role of VWF after experimental ICH. Functional outcomes, brain edema, blood-brain barrier (BBB) permeability, cerebral levels intercellular adhesion molecule-1 (ICAM-1) matrix metalloproteinase-9 (MMP-9) were measured in a mouse model...
Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation drive Alzheimer disease (AD) pathology. By regulating vascular functions inflammation in the microvasculature, a disintegrin metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) plays significant protective effect atherosclerosis stroke. However, whether ADAMTS13 influences AD pathogenesis remains unclear. Using vivo multiphoton microscopy, histological,...
In the mammalian brain, neurogenesis persists throughout embryonic period and adulthood in subventricular zone of lateral ventricle granular (dentate gyrus) hippocampus. Newborn neural progenitor cells (NPCs) two regions play a critical role structural functional plasticity regeneration after brain injury. Previous studies have reported that extremely low-frequency electromagnetic fields (ELF-EMF) could promote osteogenesis, angiogenesis, cardiac stem cells' differentiation, which indicates...
Abstract Tissue plasminogen activator (tPA) is an effective treatment for ischemic stroke, but its neurotoxicity a significant problem. Here we tested the hypothesis that recombinant ADAMTS 13 (rADAMTS 13) would reduce tPA in mouse model of stroke. We show with rADAMTS combination significantly reduced infarct volume compared mice treated alone 48 hours after The improved neurological deficits or vehicle alone. These neuroprotective effects were associated reductions fibrin deposits vessels...
Background Previously, there were only a few reports on the negative relationship between pubertal growth in height and levels of serum lipid boys. Detailed information both genders is needed.
Background: Exacerbated blood-brain barrier (BBB) damage is related with tissue plasminogen activator (tPA)-induced brain hemorrhage after stroke. Platelets have long been recognized as the cellular orchestrators of primary haemostasis. Recent studies demonstrated further that platelets are required for supporting intact mature blood vessels and play a crucial role in maintaining vascular integrity during inflammation. Therefore, we sought to investigate whether could reduce tPA-induced...
BACKGROUND: Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption blood-brain barrier ischemic brain injury. ALK (anaplastic lymphoma kinase), a cancer-associated receptor tyrosine kinase, was found play role in inflammation. In this study, we investigated inhibition murine model stroke. METHODS: Focal cerebral ischemia induced temporary occlusion right middle artery mice with filament. The...
Previous studies have shown that mortality from cardiovascular diseases in fishing villages was lower than farming villages. In contrast, few reports on the population living a tourist village appeared. Then, we report here characteristic features of town, and towns. The rural town Gunma prefecture had 15,100. working primary industry 17.1%, 17.0%. Shizuoka 11,700. 11.0%, 10.2%. 17,800. tertiary 60.2%, wholesaling or retailing 16.6%. Standardized ratios reported by health officials were...
The study aimed to evaluate the efficacy and safety of Bushenjiangya-optimized (BSJYO) granule on left ventricular diastolic dysfunction (LVDD) in hypertensive (HTN) patients.120 patients diagnosed with HTN plus LVDD were randomly assigned BSJYO group placebo group, all received basal western medicine (WM) treatment. After eight weeks treatment, we evaluated echocardiography, traditional Chinese (TCM) syndromes, 24-hour ambulatory blood pressure, liver kidney functions, adverse events. Major...
Abstract Neddylation is a ubiquitylation-like pathway that critical in various cellular functions by conjugating NEDD8 to target proteins. However, the roles of neddylation stroke, remain elusive. Here, we report conjugation increased after ischemic stroke and was abundantly present neutrophils, whereas cullin-1, key substrate neddylation, upregulated endothelium. Inhibition MLN4924, inactivated cullin-RING E3 ligase (CRL), reduced brain infarction improved functional outcomes. MLN4924...