A5100347263- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Lipid Membrane Structure and Behavior
- Neural dynamics and brain function
- Pancreatic function and diabetes
- Amino Acid Enzymes and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Wireless Power Transfer Systems
- Pharmacological Effects and Toxicity Studies
- Stress Responses and Cortisol
- Molecular Communication and Nanonetworks
- Autism Spectrum Disorder Research
- Photosynthetic Processes and Mechanisms
- Advanced Glycation End Products research
Howard Hughes Medical Institute
2024-2025
Boston Children's Hospital
2024-2025
Qingdao University
2020-2024
Affiliated Hospital of Qingdao University
2023-2024
Capital Medical University
2022
Ruijin Hospital
2022
Fudan University
2022
Zhejiang University
2015-2021
Zhejiang Chinese Medical University
2021
Ningbo University
2021
Abstract The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation SNr parvalbumin + (PV) GABAergic neurons amplifies seizure activities kindling- and kainic acid-induced TLE models, whereas selective inhibition these alleviates activities. severity seizures bidirectionally regulated by manipulation PV fibers projecting to parafascicular nucleus (PF). Electrophysiology...
Corticotropin releasing factor (CRF) network in the oval nucleus of bed nuclei stria terminalis (ovBNST) is generally indicated stress, but its role female-biased susceptibility to anxiety unknown. Here, we established a stress paradigm. We found that CRF release ovBNST during showed pattern, and neurons were more prone be hyperexcited female mice both vitro vivo studies. Moreover, optogenetic modulation exchange activation pattern between male could reverse their anxiety. Last, receptor...
Optical modulation of nervous system becomes increasingly popular as the wide adoption optogenetics. For these applications, upconversion materials hold great promise novel photonic elements. This study describes an based strategy for combinatorial neural stimulation both in vitro and vivo by using spectrum-selective nanoparticles (UCNPs). NaYF4 UCNPs are used to absorb near-infrared (NIR) energy emit visible light stimulating neurons expressing different channelrhodopsin (ChR) proteins. The...
Abstract Orchestrating complex behaviors, such as approaching and consuming food, is critical for survival. In addition to hypothalamus neuronal circuits, the nucleus accumbens (NAc) also controls appetite satiety. However, specific subtypes of NAc that are involved how humoral signals coordinate regulate feeding remain incompletely understood. Here we decipher spatial diversity neuron shell (NAcSh) define a dopamine receptor D1-expressing Serpinb2- expressing subtype controlling food...
Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of entorhinal calcium/calmodulin-dependent protein kinase II α (CaMKIIα)-positive neurons, but not GABAergic retarded hippocampal epileptogenesis and reduced seizure severity, similar to low-frequency electrical (LFES). Optogenetic inhibition CaMKIIα-positive neurons blocked antiepileptic effect LFES. The...
A flexible, implantable upconversion device is reported as an all-optical solution for wireless optogenetic stimulation of spinal cord tissue in freely moving rodents, adding to the current toolsets optogenetics giving possibilities remote neural modulation.
Abstract Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the most common types medically refractory epilepsy. Deep brain stimulation (DBS) shows considerable promise for treatment TLE. However, optimal targets and parameters DBS to control seizures related impairment are still not fully illustrated. Methods In present study, we evaluated therapeutic potential in medial septum (MS) on function mouse acute chronic models. Results We found that MS...
Social novelty preference is an important aspect of social interaction for evaluating new threats and opportunities survival, but the underlying neuronal mechanism remains unclear. Here, we identify a molecularly defined medial prefrontal cortex (mPFC) excitatory neuron subtype, located in layer 5 expressing Il1rapl2 , which highly associated with deficit disorders genome-wide association studies might be responsible regulating preference. Using -Cre mouse line, show that chemogenetic...
Since solar light energy is the source of all renewable biological energy, direct usage by bacterial cell factory has been a very attractive concept, especially using to promote anaerobic fermentation growth and even recycle low-energy carbon when limiting factor. Proteorhodopsin(PR), light-driven proton pump proven couple with ATP synthesis expressed heterogeneously, an interesting simple option enable in engineered strains. However, although it was reported influence some cases,...
Anterior nucleus of thalamus (ANT) has been widely accepted as a potential therapeutic target for drug-resistant epilepsy. Although increased volume the ANT was also reported in patients with absence epilepsy, relationship between and epilepsy barely illustrated.Using chemogenetics, we evaluated effect parvalbumin (PV) neurons on pentylenetetrazole (PTZ)-induced seizures mice.We found that intraperitoneal injection PTZ (30 mg/kg) can stably induce absence-like characterized by bilaterally...
Some researchers and clinics have reported that non-drug treatments for Alzheimer disease (AD) such as electrical stimulation, light music laser transcranial magnetic stimulation may beneficial treatment effects. Following these findings, in this study, we performed multimodel physical on APP/PS1 mice using visible light, with a γ rhythm, an infrared laser. And the effects of were evaluated by behavioral analysis, content amyloid (Aβ40 Aβ42), NISSL staining hippocampal tissue slices. The...
In the past decade, significant advancements have been made in understanding brain regions and neuronal circuits regulating neurological behaviors. The endocannabinoid (eCB) system, which is ubiquitously distributed extensively involved synaptic modulation, has believed to play potential roles circuit processes related disorders. Although eCB-based pharmacological studies some clinical achievements, they still often encounter conflicting reports or undesired effects due global manipulation...