A5047002637- Gut microbiota and health
- Bacterial Genetics and Biotechnology
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Estrogen and related hormone effects
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Esophageal and GI Pathology
- Liver Disease and Transplantation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Gastroesophageal reflux and treatments
- Brain Metastases and Treatment
- Retinoids in leukemia and cellular processes
- Thyroid Disorders and Treatments
- Peripheral Nerve Disorders
- Vascular Malformations and Hemangiomas
- Vibrio bacteria research studies
- Remote-Sensing Image Classification
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Gene expression and cancer classification
- Ferroptosis and cancer prognosis
Wayne State University
2022
Detroit Medical Center
2022
Beaumont Health
2021
Icahn School of Medicine at Mount Sinai
2018
Rutgers, The State University of New Jersey
2017
University of Southern California
2012-2016
Keck Hospital of USC
2015
University of California, San Diego
2010
Massachusetts General Hospital
2003-2005
Amherst College
2000-2002
The translocation of bacteria and bacterial products into the circulation contributes to alcoholic liver disease. Intestinal overgrowth is common in patients with aims our study were investigate translocation, changes enteric microbiome, its regulation by mucosal antimicrobial proteins We used a mouse model continuous intragastric feeding alcohol or an isocaloric diet. Bacterial occurred prior observed microbiome. Quantitative intestinal microflora these animals assessed first using...
Alcoholic liver disease progresses through several stages of tissue damage, from simple steatosis to alcoholic hepatitis, fibrosis, or cirrhosis. Alcohol also affects the intestine, increases intestinal permeability and changes bacterial microflora. Liver severity correlates with levels systemic products in patients, experimental is dependent on gut derived mice. Supporting evidence for importance translocation comes animal studies demonstrating that decontamination associated decreased...
Summary Asymmetric localization of proteins is essential to many biological functions bacteria. Shigella IcsA, an outer membrane protein, localized the old pole bacillus, where it mediates assembly a polarized actin tail during infection mammalian cells. Actin provides propulsive force for intracellular movement and intercellular dissemination. Localization IcsA independent amino‐terminal signal peptide (Charles, M., Perez, Kobil, J.H., Goldberg, M.B., 2001, Proc Natl Acad Sci USA 98:...
The Shigella outer membrane protease IcsP removes the actin assembly protein IcsA from bacterial surface, and consequently modulates actin-based motility cell-to-cell spread. Here, we demonstrate that expression is undetectable in mutants lacking either of two transcriptional activators, VirF VirB. In wild-type spp., virB entirely dependent on VirF; therefore, to circumvent this regulatory cascade, independently expressed or VirB strains both activators measured levels transcription icsP...
The appropriate interval between ligation sessions for treatment of esophageal variceal bleeding is uncertain. optimal would provide eradication as rapidly possible to lessen early rebleeding while minimizing ligation‐induced adverse events. We randomly assigned patients hospitalized with acute who had successful at presentation repeat 1‐week or 2‐week intervals. Beta‐blocker therapy was also prescribed. Ligation performed the until varices were eradicated and then 3 9 months after...
Tumor tissue samples often contain an unknown fraction of stromal cells. This problem is widely known as tumor purity heterogeneity (TPH) was recently recognized a severe issue in omics studies. Specifically, if TPH ignored when inferring co-expression networks, edges are likely to be estimated among genes with mean shift between non-tumor- and cells rather than gene pairs interacting each other To address this issue, we propose Specific Net (TSNet), new method which constructs tumor-cell...
In rod-shaped bacteria, certain proteins are specifically localized to the cell poles. The nature of positional information that leads proper localization these is unclear. a screen for factors required Shigella sp. actin assembly protein IcsA bacterial pole, mutant carrying transposon insertion in mreB displayed altered targeting IcsA. phenotype cells containing was indistinguishable from nonpolar mutation or wild-type treated with MreB inhibitor A22. lacking MreB, green fluorescent (GFP)...
Human breast milk samples at early time points after parturition contain high levels of calcitonin (CT) in both normal and thyroidectomized mothers, suggesting that mammary tissue produces CT. Using blot hybridization reverse-transcriptase polymerase chain (RT-PCR) analysis rat RNA we found CT messenger is induced midpregnancy (day 12), remains elevated through late pregnancy 19) but then decreases before the day birth. RIA revealed increase from 0.3 ng/g nonpregnant animals to peak 1.6 on...
To evaluate gastroenterologists' use of esophagogastroduodenoscopy (EGD) for positive fecal occult blood test (FOBT).Colonoscopy is recommended when an FOBT performed colorectal cancer screening positive. Guidelines suggest no further evaluation if anemia and gastrointestinal (GI) symptoms are absent.Online surveys included 4 vignettes: in average-risk adults 50 years age or older with/without iron-deficiency upper GI symptoms. For each scenario, respondents were asked they would perform...
Land cover mapping of the Amazon Basin provides valuable insight for assessment regional land use and extent human encroachment, which can help environmentalists detect respond to deforestation. Current methods rely on coarse-resolution imagery, limits effectiveness at identifying small-scale This paper proposes an ensemble-based method utilizing weighted voting heterogeneous classifiers accurate scalable labeling high-resolution satellite imagery rainforest. The ensemble learner relies...
Although prohibited since the 1970s, insider dealing has only become a crime in Hong Kong 2002. After briefly discussing reasons for and against prohibition of dealing, this paper outlines legislative history regulatory mechanism Kong, critically analyses current regime. This argues that law should be made simpler, fairer, to conform better basic civil liberty.
Peripheral nerve ultrasound is a well-established imaging technique to evaluate certain peripheral pathologies. However, there poor correlation between abnormalities of nerves and electrodiagnostic or clinical evidence axonal loss. This significant limitation ultrasound, as many diseases encountered in settings are related Furthermore, loss directly correlates with disability all diseases. due the floor effects often studies, these correlations, well definitive diagnoses, challenging. Thus,...