A5085129328- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Celiac Disease Research and Management
- Microscopic Colitis
- HIV, Drug Use, Sexual Risk
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Opioid Use Disorder Treatment
- Renal Transplantation Outcomes and Treatments
- Liver Diseases and Immunity
Örebro University
2014-2025
Örebro University Hospital
2008-2017
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
Celiac disease (CeD) has been associated with a low response to hepatitis B (HBV) vaccination, but guidelines for testing and revaccination among individuals CeD are sparse. We examined the risk of future HBV in population-based Swedish cohort. Furthermore, we rate prior infection patients. All Sweden diagnosed biopsy-verified between 1990 2017 were identified through ESPRESSO Each individual was matched by age, sex, calendar year, birth country (Nordic vs. other) up 5 reference individuals....
Abstract Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), and surveillance recommended patients without cirrhosis when exceeds an incidence rate (IR) of 0.2%. Populations in Asia sub‐Saharan Africa have been associated with HCC at younger ages, but the after immigration to Western countries should be investigated. The aim this study was by age country origin people chronic HBV Sweden. Through national registers, residents diagnosis...
Previous studies on hepatitis C cascade of care have been mainly focused diagnosis and treatment rate, while less attention has given to patients lost follow-up (LTFU) after diagnosis. Analyses this latter issue population level are missing.In nationwide study people with HCV, we aimed estimate the proportion LTFU HCV diagnosis, characterize them, analyze their other healthcare contacts.Patients diagnosed chronic in Swedish National Patient Register during 2001-2011 still alive December 31,...
Chronic hepatitis C virus (HCV) infection is an established cause of liver cancer, and recent studies have suggested a link with kidney cancer. The aim this study was to evaluate risk cancer in relation HCV nationwide registry-based Swedish residents diagnosed between 1990 2006. A total 43 000 individuals chronic were included, the mean follow-up time 9.3 years. Observed incidence mortality cohort compared expected values based on age-adjusted sex-adjusted rates general population. Risk...
The aim of this study was to assess the risk hepatocellular carcinoma (HCC) and other primary liver cancers (PLC) in nationwide cohort hepatitis C virus (HCV) infected patients Sweden. basis total HCV-cohort notified 1990-2004, after excluding 3238 people also reported with B, consisted 36 126 contributing an observation time 246 105 person-years. most common route transmission intravenous drug use (57%). national Cancer Registry used for follow-up, 354 developed PLC (mainly HCC), whom 234...
In many countries, including Sweden, the birth cohorts with highest prevalence of hepatitis C virus (HCV) infection have now reached ages high risk primary liver cancer (PLC). The aims this study were to investigate temporal trends in PLC incidence and relative risks among people diagnosed HCV between 1990 2015.The cohort (n = 52,853) was compared a matched non-HCV comparison 523,649). Both national Cancer Register (CR) Cause Death (DR) used for follow-up. crude age-standardized rates...
Background The hepatitis C virus (HCV) prevalence in Sweden is estimated to be <0.5%, but unclear pregnant women. dominating route of transmission drug use (DU), blood transfusions constituted a risk before 1992. aim was examine the anti-HCV and factors for HCV among women their partners evaluate screening strategies.Methods Pregnant Örebro County southern Stockholm were offered HCV-screening when visiting an antenatal clinic 2013-2016, completed questionnaire concerning country birth,...
Background and aims Direct-acting antivirals (DAAs) against HCV have an immune modulatory effect, this could possibly lead to a decreased tumour control. We, therefore, aimed assess the risk of extrahepatic cancer (EHC) during first years after DAA treatment. Methods Results This is nationwide cohort study with prospectively collected data for 19 685 persons HCV, 4013 treated, 3071 interferon (IFN) treated 12 601 untreated, from 2008 2016. Follow-up time was maximum 3 years. The EHC compared...
Aims To investigate liver-related and all-cause mortality among amphetamine users with hepatitis C virus (HCV) infection compare this opioid HCV the uninfected general population. Methods In national register study of in persons notified 1990–2015 a substance-related diagnosis Sweden, (n = 6,509) were compared 5,739) matched comparison group without infection/substance use 152,086). Results Amphetamine observed for 91,000 years 30.1% deceased. Crude was 1.8 times higher than (crude rate...
<title>Abstract</title> <bold>Objectives</bold>: Celiac disease (CeD) has been associated with a low response to hepatitis B (HBV) vaccination, but guidelines for testing and revaccination among individuals CeD are sparse. We examined the risk of future HBV in population-based Swedish cohort. Furthermore, we rate prior infection patients. <bold>Methods</bold>: All Sweden diagnosed biopsy-verified between 1990-2017 were identified through ESPRESSO Each individual was matched by age, sex,...
Aims: Hepatitis C virus (HCV) is a slowly progressive disease, often transmitted among people who inject drugs (PWID). Mortality in PWID high, with an overrepresentation of drug-related causes. This study investigated the risk death patients chronic hepatitis infection or without illicit substance use disorder (ISUD).Methods: Patients HCV were identified using Swedish National Patient Registry according to International Classification Diseases-10 (ICD-10) code B18.2, ≤5 matched comparators...