A5044182626- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- Colorectal Cancer Screening and Detection
- Hepatitis Viruses Studies and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- Biomedical Research and Pathophysiology
- Helicobacter pylori-related gastroenterology studies
- Sepsis Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Education, Healthcare and Sociology Research
- Metastasis and carcinoma case studies
- Vaccine Coverage and Hesitancy
- Genital Health and Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Thyroid Cancer Diagnosis and Treatment
- Complement system in diseases
- Herpesvirus Infections and Treatments
- Neuroendocrine regulation and behavior
Copenhagen University Hospital
2009-2024
Rigshospitalet
2009-2024
University of Copenhagen
1996-2024
The Capital Region Pharmacy
2014
Bispebjerg Hospital
1995
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
Summary The number of hepatitis C virus ( HCV ) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used forecast two treatment scenarios: (i) the impact increased efficacy keeping treated patients constant and (ii) increasing rate. This analysis suggests that successful diagnosis a small proportion can contribute significantly reduction burden in countries studied. largest ‐related morbidity mortality occurs when combined higher...
The aim of this study was to examine regulatory T cells (Tregs) in peripheral blood and liver tissue patients with chronic hepatitis C virus (HCV) mono-infection HIV/HCV co-infection. In a cross-sectional were included 51 HCV infection, 24 co-infection healthy individuals. CD4⁺ CD8⁺ Tregs determined using flow cytometry. Fibrosis examined by transient elastography. Inflammation, fibrosis biopsies from 12 patients. Increased frequency found co-infected [median: 6.4% (IQR: 5.7-6.9) 1.0%...
Predictive factors for initiation of antiviral therapy in chronically infected hepatitis C virus (HCV) patients are not fully elucidated. The aim this study was to determine predictive treatment with standard or pegylated interferon either alone combined ribavirin. A Danish cohort individuals HCV used and observation time calculated from the date inclusion death, last clinical observation, 1 January 2007, start treatment-naïve patients. Kaplan-Meier survival analysis construct event curves....
Abstract Altered T cell homeostasis in chronic hepatitis C virus ( HCV ) infection has been demonstrated. However, it is unknown whether fibrosis associated with more perturbed infection. The aim of this study was to examine and compare subsets including recent thymic emigrants RTE ), naive, memory, senescent, apoptotic IL ‐7 receptor α CD 127) expressing 4 + 8 cells as well telomere length interferon‐γ production ‐infected patients n = 25) without 26) healthy controls 24). Decreased...
Inflammatory status affects healthy brain function and also low-grade inflammation putatively contributes to the pathophysiology of Major Depressive Disorder (MDD). This psychoneuro-immunological interplay is complex, bidirectional, not fully understood. Also, it clear what extent depressive states induce and/or if increased leads symptoms by affecting biology including serotonin signaling. The 4 receptor (5-HT4R) an interesting new antidepressant target; direct stimulation has...
Background: Butyrate has antineoplastic properties against colorectal cancer cells and is the preferred oxidative substrate for colonocytes. Like acetate propionate (short-chain fatty acids; SCFAs), butyrate produced by colonic fermentation of dietary fibre. Methods: Twenty patients resected were treated with 20 g/day fibre Plantago ovuta seeds 3 months, which increased intake 17.9 ± 0.8 g/day, from basal levels 19.2 1.7 g/day; 17 completed study. Faecal samples obtained on eight occasions,...
Increased risk of both cardiovascular disease (CVD) and bleeding has been found in patients with chronic hepatitis C (CHC) infection, a re-balanced hemostasis proposed. The aim this study was to investigate functional whole blood coagulation platelet function CHC infection. prospective included 82 infection (39 advanced liver fibrosis 43 no or mild fibrosis) 39 healthy controls. A total 33 were treated for achieved sustained virological response (SVR). Baseline post-treatment samples...
Knowledge about mortality rates (MRs) in patients with chronic hepatitis C (CHC) cirrhosis is limited. This study aimed to estimate all-cause MRs among CHC or without Denmark compared the general population. Patients registered Danish Database for Hepatitis B and a liver fibrosis assessment were eligible inclusion. Liver was assessed by means of biopsy, transient elastography, clinical cirrhosis. Up 20 sex- age-matched individuals per patient identified Data extracted from nationwide...
Objective: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered immunoglobulin at birth, vaccination against HBV birth after 1, 2 12 months. The purpose of this study was determine the risk vertical transmission in with chronic infection, investigate antibody response possible maternal predictive factors transmission.Materials methods: Through Danish Database Hepatitis C, we identified 589 who had given 686...
The study aimed to determine adjusted all-cause mortality and cause of death in persons with chronic hepatitis B virus (HBV) infection compared age- sex-matched from the general population. We used nationwide registers identify aged ≥18 years HBV 2002-2017 Denmark included 10 controls for each. Follow-up was 6 months after diagnosis until death, emigration, or 31 December 2017. Mortality rate ratios (MRRs) age, sex, employment, origin comorbidity were calculated using Poisson regression....
We aimed to determine incidence of hepatocellular carcinoma (HCC) and decompensated liver cirrhosis in persons with chronic hepatitis B virus (HBV) infection Denmark stratified by disease phase, cirrhosis, treatment status at baseline. Additionally, we assess the prognostic value PAGE-B HCC risk score a mainly non-cirrhotic population.In this register-based cohort study, included all individuals over age 18, HBV first registered between 2002 2016 least one three nationwide registers. The...
Summary Aim: The prevalence of iodine- and thyroglobulin-nega-tive findings was evaluated in all patients with differentiated thyroid cancer (DTC) treated from 1961 until 1998 at the Department Nuclear Medicine, University Hospital Hamburg-Eppendorf. Methods: A total 490 papillary (PCA) 242 follicular (FCA) were analyzed retrospectively. Patients divided into four groups: 1: no recurrence, 2: recurrent disease, 3: primary metas-tatic/progressive disease 4: inconclusive follow-up. Results...
Direct-acting antiviral has replaced pegylated interferon-α and ribavirin-based treatment in the of chronic hepatitis C virus (HCV) infection. While is immune modulating causes lymphopenia, interferon-free regimens seem to be well-tolerated. This study aimed compare T-cell homeostasis before, during, after HCV with or without patients A total 20 infection were treated ribavirin, six an regimen. All for a minimum 12 weeks. Interferon-α caused increase density receptor IL-7 (IL-7Rα) during...
Genetic variation upstream of the apoptosis pathway has been associated with outcome hepatitis C virus (HCV) infection. We investigated genetic polymorphisms in intrinsic to assess their influence on sustained virological response (SVR) pegylated interferon-α and ribavirin (pegIFN/RBV) treatment HCV genotypes 1 3 infections. conducted a candidate gene association study prospective cohort 201 chronic HCV-infected individuals undergoing pegIFN/RBV. Differences between groups were compared...
Unlike mucocutaneous infections, disseminated herpes simplex virus infections are rare and often fatal owing to acute liver failure (ALF). Typically, the course of disease is rapid lack specific symptoms may result in delay diagnosis. This study reports a case genital caused by simplex-type 2 that resulted ALF. The patient was 24-y-old woman with 1 y history Crohn's disease, treated oral prednisolone. She hospitalized fatigue, anorexia abdominal pain. Blood tests showed pancytopenia, renal...