A5021516311- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Cervical Cancer and HPV Research
- Liver Diseases and Immunity
- HIV Research and Treatment
- Molecular Biology Techniques and Applications
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Reproductive tract infections research
- HIV/AIDS Research and Interventions
- Urinary Tract Infections Management
- Apelin-related biomedical research
- Parvovirus B19 Infection Studies
- Viral gastroenteritis research and epidemiology
- Genital Health and Disease
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Urinary Bladder and Prostate Research
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
University Hospital for Infectious Diseases "Dr Fran Mihaljevic"
2016-2025
University of Zagreb
2015-2024
University Hospital Centre Zagreb
2012-2024
Carol Davila University of Medicine and Pharmacy
2023
European Society of Clinical Microbiology and Infectious Diseases
2018
Norfolk Community Health and Care NHS Trust
2000
University of Rochester
1999
University of New Mexico
1999
University of Graz
1997
University College Hospital
1986
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
The burden of disease due to chronic viral hepatitis constitutes a global threat. In many Balkan and Mediterranean countries, the remains largely unrecognized, including in high-risk groups migrants, because lack reliable epidemiological data, suggesting need for better targeted surveillance public health gains. liver B C is increasing ageing unvaccinated populations migration, probable increase drug injecting. Targeted vaccination strategies virus (HBV) among risk harm reduction...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is the most common associated with systemic changes in immune response, which might be coronavirus 2019 (COVID-19) severity. The aim of this study was to investigate impact NAFLD on COVID-19 severity and outcomes. Methods A prospective observational included consecutively hospitalized adult patients, between March June 2021, severe COVID-19. Patients were screened for by ultrasound subsequently diagnosed NAFLD. daily followed until...
Metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been linked with sepsis outcomes. However, the immune mechanisms by which MASLD aggravates severity are unknown. This prospective cohort study aimed to analyze serum cytokine and chemokine kinetics in patients community-acquired sepsis. Out of 124 patients, 68 (55%) were diagnosed MASLD. There no differences age, sex, comorbidities, baseline severity, or etiology between groups. Serum concentrations 27 cytokines...
Please cite this paper as: Papic et al. (2011) Liver involvement during influenza infection: perspective on the 2009 pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5. Elevation of liver transaminase levels is a frequent observation systemic infections. The aim our study was to investigate damage pandemic A/H1N1 infection in comparison with seasonal influenza. Serum aspartate aminotransferase, alanine gamma‐glutamyl transpeptidase (GGT) were significantly higher patients compared...
HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons enhance HBV oncogenic-properties. Furthermore, as a consequence the overlapping structure genome, some or stop-codons derive from drug-resistance RT. This study is aimed at gaining insight prevalence characteristics immune-associated escape mutations, chronically HBV-infected patients...
Background: While it has been shown that steatotic liver disease (SLD) is associated with systemic changes in immune response, the impact of SLD on sepsis outcomes not yet established. The aim this study was to investigate association between and severity outcomes. Methods: A prospective observational included consecutively hospitalized adult patients community-acquired during a 16-month period. Results: Of 378 (49.5% male, median age 69, IQR 57–78 years), 174 (46%) were diagnosed SLD....
ABSTRACT In the present study we comparatively evaluated first- and second-generation Digene Hybrid Capture assays for detection of human papillomaviruses (HPV) associated with high or intermediate risk cervical cancer in specimens. Concordant results were obtained 468 483 (96.8%) All 15 specimens which gave repeatedly discordant positive by test only, 14 them tested PCR positive. The enhanced sensitivity assay is mainly a result reformulation hybridization reagents and, to lesser extent,...
Objectives – The aim of our study was to determine whether cerebrospinal fluid (CSF) patients with tick-borne encephalitis (TBE) contains CXCL10, CXCL11, p40 subunit interleukin-12 (IL-12)/IL-23, IL-18 and IL-15. We compared serum CSF concentrations CXCL10 analysed the possible concentration gradient this chemokine between periphery central nervous system. Materials methods enrolled 19 TBE 10 non-inflammatory neurological diseases. Results contained (median 217 pg/ml), CXCL11 (8.3...
<b>Aims:</b> To prospectively assess the WHO clinical decision rule (CDR) for group A beta haemolytic streptococcal (GABHS) pharyngitis in three countries. <b>Methods:</b> prospective, observational cohort study urban outpatient clinics Rio de Janeiro, Cairo, and Zagreb. There were 2225 children aged 2–12 years with cough, rhinorrhoea, red or sore throat; 1810 of these throat included analysis. <b>Results:</b> The proportion presenting found to have GABHS ranged from 24.6% (Brazil) 42.0%...
Abstract The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon‐alpha‐based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, A dominant Northern Europe. However, distribution unknown several Central Eastern European countries. Data described 1313 HBsAg‐positive recruited at 14 referral centers eight There were only very few cases B, C, E, F, H infection while D found 42% 48%...
ObjectivesTo evaluate the utility of rapid antigen detection testing (RADT) for diagnosis group A streptococcal (GAS) pharyngitis in pediatric outpatient clinics four countries with varied socio-economic and geographic profiles.MethodsWe prospectively evaluated a commercial RADT children aged 2–12 years presenting symptoms to urban Brazil, Croatia, Egypt, Latvia between August 2001 December 2005. We compared performance culture using diagnostic agreement statistics, including sensitivity,...
Summary Due to the introduction of newer, more efficacious treatment options, there is a pressing need for policy makers and public health officials develop or adapt national hepatitis C virus ( HCV ) control strategies changing epidemiological landscape. To do so, detailed, country‐specific data are needed characterize burden chronic infection. In this study 17 countries, literature review published unpublished on prevalence, viraemia, genotype, age gender distribution, liver transplants...
BackgroundEuropean guidelines recommend treatment of chronic hepatitis B virus infection (CHB) with the nucleos(t)ide analogs (NAs) entecavir or tenofovir. However, many European CHB patients have been exposed to other NAs, which are associated therapy failure and resistance. The CAPRE study was performed gain insight in prevalence characteristics NA resistance Europe.
Alveolar echinococcosis is a parasitic disease caused by the tapeworm larval stage of Echinococcus multilocularis. This zoonotic has not been known to occur in Croatia. We report confirmed case human alveolar patient Croatia who had never visited E. multilocularis-endemic area.
Non-alcoholic fatty liver disease (NAFLD) is identified as a risk factor for developing severe COVID-19. While NAFLD associated with chronic low-grade inflammation, mechanisms leading to immune system hyperactivation remain unclear. The aim of this prospective observational study analyze cytokine profiles in patients COVID-19 and NAFLD. A total 94 were included. Upon admission, clinical laboratory data collected, ultrasound was performed determine the presence steatosis, subsequently, 51...