A5102864853- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Colorectal Cancer Treatments and Studies
- Vaccine Coverage and Hesitancy
- Advances in Oncology and Radiotherapy
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Liver Diseases and Immunity
- Bacterial biofilms and quorum sensing
- Colorectal and Anal Carcinomas
- Pediatric Hepatobiliary Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Orthopedic Infections and Treatments
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Water Systems and Optimization
- Diabetes and associated disorders
Exact Sciences (United States)
2023-2025
Center for Disease Analysis
2017-2025
Western University
2020-2023
Janssen (Belgium)
2023
York University
2023
University of Toronto
2023
Institute of Medical Sciences
2023
LMC Diabetes & Endocrinology (Canada)
2020
University of Calgary
2020
University of British Columbia
2020
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis hepatocellular carcinoma globally. This burden is expected to increase as epidemics obesity, diabetes metabolic syndrome continue grow. The goal this analysis was use Markov model forecast NAFLD using currently available data.A used estimate NASH progression in eight countries based on data for adult prevalence obesity type 2 mellitus (DM). Published estimates expert...
Summary Background Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) account for an increasing proportion of in the Asia‐Pacific region. Many areas region are experiencing epidemics metabolic syndrome among rapidly ageing populations. Aims To estimate using modelling growth NAFLD populations, including cases with significant fibrosis that most likely to experience advanced related mortality. Methods A progression model was used summarise project populations...
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) account for a large growing proportion of burden globally. The NAFLD/NASH manifests in increasing levels advanced primary cancer Australia. A Markov model was used to forecast NAFLD Australia through 2030.A estimate fibrosis progression, cancer, deaths among the Australian population, with changes incident cases based on long-term trends prevalence obesity. Published estimates surveillance data were applied...
Abstract Background Antiseptic and antibacterial solutions used for intraoperative irrigation are intended to kill bacteria thereby decrease the incidence of surgical site infections. It is unknown if concentrations exposure times commonly prophylaxis in clean cases (povidone-iodine 0.35% 3 minutes) effective against biofilm that present implant Currently, povidone-iodine (0.35%), chlorhexidine (0.05%), sodium hypochlorite (0.125%), triple solution all being off-label wound after débridement...
<h3>Background:</h3> Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) account for a growing proportion of cases, there is need to better understand future burden. We used modelling framework forecast the burden NAFLD NASH Canada. <h3>Methods:</h3> Markov model fibrosis progression from stage F0 (no fibrosis) F4 (compensated cirrhosis) subsequent decompensated cirrhosis, hepatocellular carcinoma, transplantation liver-related death among Canadians with 2019...
This cross-sectional study estimates the number of average-risk colorectal cancer screening–eligible individuals in US since Preventive Services Task Force updated its recommendations 2021.
The 2016 World Health Assembly endorsed the elimination of hepatitis B virus (HBV) infections by 2030. However, HBV prevalence in Western countries, where historical is low and highly impacted immigration trends, remains uncertain making planning difficult. We aimed to develop a more accurate estimate identify key immigrant populations that need be screened, vaccinated, treated achieve targets.US data from 1900 forward country-specific modeled age sex were used immigrated entering US, new...
Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and related mortality globally. However, most the infected individuals in United States remain undiagnosed untreated. There need to understand more completely economic burden impact removing treatment restrictions increasing diagnosis treatment. The PRoGReSs model, dynamic HBV model that tracks population by year, stage, gender, was used quantify chronic from 2020 2050 based on four scenarios: status quo (base)...
Summary Due to the introduction of newer, more efficacious treatment options, there is a pressing need for policy makers and public health officials develop or adapt national hepatitis C virus ( HCV ) control strategies changing epidemiological landscape. To do so, detailed, country‐specific data are needed characterize burden chronic infection. In this study 17 countries, literature review published unpublished on prevalence, viraemia, genotype, age gender distribution, liver transplants...
Objective: This analysis estimated the outcomes of triennial blood-based colorectal cancer (CRC) screening at various adherence, including perfect compared with multi-target stool DNA (mt-sDNA) reported real-world adherence rate.
88 Background: There are an estimated 60 million individuals in the US who not up-to-date with average-risk colorectal cancer (CRC) screening, as screening rates and adherence have remained stubbornly below national target of 80%. Efforts ongoing to improve CRC performance participation, including development new blood-based tests. Despite high expectations for these tests, remains lower than other guideline-recommended strategies, particularly respect advanced precancerous lesion (APL)...
89 Background: With estimates of over 150,000 incident and 50,000 fatal colorectal cancer (CRC) cases in 2024, efforts are ongoing to improve the national screening performance engagement US. The Centers for Medicare & Medicaid Services (CMS) have established criteria covering new blood-based CRC tests if minimum sensitivity specificity thresholds met. However, current challenged by their relative inability detect advanced precancerous lesions (APLs). At present, importance APL versus on...
Abstract The substantial carbon footprint imparted by medical services warrants increased attention to their environmental impact. National guideline organizations such as the US Preventive Services Task Force (USPSTF) recommend multiple modalities for average-risk colorectal cancer (CRC) screening with varying resource intensity. aim of this study was quantify burden 2 most used CRC modalities, colonoscopy and multi-target stool DNA (mt-sDNA) test. A validated microsimulation model estimate...
As a result of epidemic levels obesity and diabetes mellitus, nonalcoholic fatty liver disease (NAFLD) steatohepatitis (NASH) will contribute to increases in the liver-related burden Switzerland.
<h3>Background:</h3> The World Health Organization recommends universal birth dose vaccination for hepatitis B virus (HBV), yet only 3 provinces and territories in Canada provide vaccination, Canadian-born children Ontario are acquiring HBV before adolescent vaccination. We sought to determine whether and/or infant is cost-effective. <h3>Methods:</h3> used a dynamic model that incorporates population by year, disease stage, sex the influence of immigration quantify economic burden chronic...
As of 2019, the United States (US) was not on track to achieve targets for elimination, due increasing incidence and treatment barriers. In 2020, COVID-19 pandemic disrupted HCV services globally in US. healthcare normalize, there is an urgent need reassess progress evaluate scenarios that restore a pathway toward elimination.We updated validated Markov model estimate HCV-related morbidity mortality Five were developed bookend possible outcomes wake pandemic. These included 1) return...
The United States Preventive Services Taskforce (USPSTF) recently recommended lowering the age for average-risk colorectal cancer (CRC) screening from 50 to 45 years. While initiating at versus provides a greater opportunity CRC early detection and prevention, full profile of benefits, risks, cost-effectiveness expanding screen-eligible population requires further evaluation.The costs clinical outcomes triennial multi-target stool DNA [mt-sDNA], other non-invasive stool-based modalities...
Objectives. We quantified the economic cost of selected environmental factors among North Carolina children living in substandard housing. Methods. gathered data on direct medical care costs for specific childhood conditions associated with commonly found Medical claims 2006 and 2007 were obtained from BlueCross BlueShield Department Health Human Services. Indirect based part nonmedical several previous studies. Results. Total (direct indirect) assessed exceeded $92 million $108 2007....