A5080216454- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Hepatitis C virus research
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism and Genetic Disorders
- Aldose Reductase and Taurine
- Diabetes and associated disorders
- Obesity, Physical Activity, Diet
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Pharmacological Effects and Toxicity Studies
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
Fondazione Italiana Fegato
2003-2021
Ospedale Regionale di Locarno
2017-2019
Azienda Unita' Sanitaria Locale Di Modena
2007-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2016
AREA Science Park
2005-2015
Istituto Ramazzini
2008-2014
Italian Society of Physiotherapy
2010
County Hospital
2010
Ospedale per gli Infermi
2010
IGEA Clinical Biophysics (Italy)
2009
Fatty liver (FL) is the most frequent disease in Western countries. We used data from Dionysos Nutrition & Liver Study to develop a simple algorithm for prediction of FL general population.216 subjects with and 280 without suspected were studied. was diagnosed by ultrasonography alcohol intake assessed using 7-day diary. Bootstrapped stepwise logistic regression identify potential predictors among 13 variables interest [gender, age, ethanol intake, alanine transaminase, aspartate...
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis hepatocellular carcinoma globally. This burden is expected to increase as epidemics obesity, diabetes metabolic syndrome continue grow. The goal this analysis was use Markov model forecast NAFLD using currently available data.A used estimate NASH progression in eight countries based on data for adult prevalence obesity type 2 mellitus (DM). Published estimates expert...
Background: Although hepatic steatosis is seen with increasing frequency in clinical practice, its prevalence and risk factors are unknown. Objective: To investigate the of for steatosis, such as alcohol consumption obesity. Design: Cross-sectional, observational study. Setting: Participants Dionysos Study. Patients: 257 participants assigned to one four categories (67 controls, 66 obese persons, 69 heavy drinkers, 55 drinkers). Measurements: Ethanol intake, assessed by a validated...
Abstract The prevalence of and the risk factors for fatty liver have not undergone a formal evaluation in representative sample general population. We therefore performed cross-sectional study town Campogalliano (Modena, Italy), within context Dionysos Project. Of 5,780 eligible persons aged 18 to 75 years, 3,345 (58%) agreed participate study. Subjects with suspected disease (SLD), defined on basis elevated serum alanine aminotransferase (ALT) γ-glutamyl-transferase (GGT) activity,...
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are increasingly relevant public health issues owing to their close association with the worldwide epidemics of diabetes obesity. NAFLD/NASH is one most common chronic diseases increases 5-year direct indirect care costs by an estimated 26% [[1]Baumeister S.E. Volzke H. Marschall P. John U. Schmidt C.O. Flessa S. et al.Impact on utilization in a general population: observation.Gastroenterology. 2008; 134:...
Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common worldwide. The prevalence of NAFLD in general population Western countries 20–30%. About 2–3% estimated to have non-alcoholic steatohepatitis (NASH), which may progress cirrhosis and hepatocarcinoma. As a rule, higher males increases with increasing age, it influenced by diagnostic method characteristics population, especially lifestyle habits. Population-based studies provide better estimates as compared autoptic...
Background —The Dionysos Study is a cohort study of the prevalence chronic liver disease in general population two northern Italian communities. It included 6917 subjects, aged 12–65 (69% total population). Aims aim this part was to examine relationship daily alcohol intake, type alcoholic beverage consumed, and drinking patterns presence induced damage an open population. Patients methods —6534 free virus related participating first cross-sectional study, were fully examined. Each subject...
Nonalcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of metabolic syndrome and may evolve into hepatocellular carcinoma (HCC). Only scanty clinical information is available on HCC in NAFLD. The aim this multicenter observational prospective study was to assess features patients with NAFLD-related (NAFLD-HCC) compare them those hepatitis C virus (HCV)-related HCC. A total 756 either NAFLD (145) or HCV-related chronic (611) were enrolled secondary care Italian centers....
Data on the prevalence of chronic liver disease, derived from selected series hospitalized patients or mortality registers, underestimate disease. The Dionysos Study is a cohort study that investigated for first time disease in general population. All citizens two towns northern Italy, Campogalliano and Cormons, aged 12 to 65 yr were contacted by letter. From March 1991 through 1993, 6,917 total 10,150 enrolled (compliance, 69%). standardized protocol each enrollee included (a)...
The authors summarize and update the most recent knowledge in field of prevalence, natural history incidence Non Alcoholic Fatty Liver Disease (NAFLD) Steatohepatitis (NASH). These novel diseases, firstly recognized at beginning second millennium, arose suddenly to attention clinicians, because they are hepatic expression "so-called" metabolic syndrome. Due epidemic burden obesity, diabetes, NAFLD NASH will become soon probably common disease worldwide, surely keep busy our future young...
BACKGROUND The severity, clinical course, and risk of hepatitis C virus (HCV) related chronic liver disease are still rather poorly defined. AIMS To investigate the prevalence, factors, severity HCV in general population, whether infection with a specific genotype is associated an increased cirrhosis or hepatocellular carcinoma. METHODS RNA determination by polymerase chain reaction (PCR) genotyping were performed all anti-HCV positive subjects belonging to Dionysos study (6917 subjects)....
Liver steatosis is often found in association with common cardiometabolic disorders, conditions that may all occur a shared context of abdominal obesity and dyslipidemia. An algorithm for identifying liver the fatty index (FLI). The lipid accumulation product (LAP) an formulated representative sample US population to identify disorders. Because FLI LAP share two components, namely waist circumference fasting triglycerides, we evaluated ability same study from Northern Italian town where was...
Using the general population of Dionysos Study, we followed up 144 subjects without fatty liver (FL−) and 336 with (FL+) for a median time 8.5 years. All had suspected disease (SLD) defined as altered enzymes, high mean corpuscular volume, or low platelet count in absence HBV HCV infection. Ethanol intake was assessed using food frequency questionnaire, FL diagnosed ultrasonography. The incidence remission rates were 18.5 55.0 per 1,000 person-years. Progression to cirrhosis HCC rare both...