A5067243110- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Microscopic Colitis
- Alcohol Consumption and Health Effects
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Healthcare Policy and Management
- Appendicitis Diagnosis and Management
- Chronic Disease Management Strategies
- Pancreatitis Pathology and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Coding and Health Information
- Colorectal Cancer Surgical Treatments
- Celiac Disease Research and Management
- Nutrition and Health in Aging
- Hepatitis Viruses Studies and Epidemiology
- Tryptophan and brain disorders
University of Calgary
2016-2025
Western University
2020-2025
Public Health Ontario
2025
Newcastle upon Tyne Hospitals NHS Foundation Trust
2024
University of Health Sciences Lahore
2024
MRC Clinical Trials Unit at UCL
2023
University College London
2023
Mid Yorkshire Hospitals NHS Trust
2023
Pinderfields Hospital
2023
West Midlands Deanery
2023
Few population-based studies have evaluated pyogenic liver abscess (PLA) in North America. We assessed the incidence of PLA and predictors mortality.We used Nationwide Inpatient Sample to identify all patients with discharges for (ICD-9 572.0) between 1994 2005. Multivariable logistic regression analysis was performed determine whether mortality associated patient hospital characteristics including comorbidities, interventions, bacterial cultures. determined annual US population temporal...
Objective Depression is associated with IBD, but the effect of antidepressants on IBD has been sparsely studied. We assessed impact depression and antidepressant therapies development IBD. Design The Health Improvement Network (THIN) was used to identify a cohort patients new-onset from 1986 2012. THIN who did not meet defining criteria for were part referent group. outcome incident Crohn’s disease (CD) or ulcerative colitis (UC). Cox proportional hazards modelling performed evaluate rate UC...
Abstract Background: Liver biopsy is an important tool in the management of patients with liver disease. Because practices may be changing, we studied patterns use a large Canadian Health Region. We aimed to describe trends utilization and incidence costs complications from population‐based perspective. Methods: Administrative databases were used identify percutaneous biopsies performed between 1994 2002. Significant identified by reviewing medical records hospitalized within 7 days those...
The outcomes of pregnancy in patients with cirrhosis are poorly described. Our objective was to assess obstetric cirrhotic women and their infants from a population-based perspective.We analysed the 1993-2005 US Nationwide Inpatient Sample database identify hospitalizations among (n=339) controls matched on age, hospital year (n=6625). effect maternal fetal evaluated using regression models adjustment for patient factors.Between 1993 2005, 114 antepartum 225 delivery admissions were...
Background Liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) is a validated method for noninvasively staging liver fibrosis. Most hepatic complications occur in patients with advanced Our objective was to determine the ability of LSM TE predict and mortality large cohort chronic disease. Methods In consecutive adults who underwent between July 2008 June 2011, we used Cox regression independent association death or (decompensation, hepatocellular carcinoma,...
Rituximab, an anti-CD20 monoclonal antibody that selectively depletes B cells, has shown promise in autoantibody-associated, immune-mediated disorders. As ursodeoxycholic acid (UDCA) is not successful all patients with primary biliary cirrhosis (PBC), additional treatment options are necessary. The objective of this study was to assess the safety and efficacy rituximab PBC refractory UDCA.Fourteen UDCA received two infusions (1,000 mg) 2 weeks apart. outcome normalization and/or 25%...
Patient, clinician, and system-related barriers may affect adherence to hepatocellular carcinoma (HCC) surveillance programmes. The impact of a dedicated automated recall HCC programme on retention rates in patients eligible for screening is unknown. We aimed describe evaluate large publicly funded healthcare system. Data were collected from January 1, 2013, December 31, 2022, retrospective cohort subjects enrolled semi-annual as per the American Association Study Liver Disease guidance...
The recent epidemiology and outcomes of primary biliary cirrhosis (PBC) in North America are incompletely described, partly due to difficulties case ascertainment. In light their availability, broad coverage, limited expense, administrative databases may facilitate such investigations. We used population-based data (inpatient, ambulatory care, physician billing databases) a validated International Classification Diseases coding algorithm describe the natural history PBC Calgary Health Region...
Liver transplant recipients and their infants may have an increased risk of obstetric complications. Our objective was to describe pregnancy outcomes in women with a prior from population-based perspective. We analyzed the 1993–2005 US Nationwide Inpatient Sample database identify hospitalizations among (n = 206) controls matched by age, hospital, year 4060). The effect transplantation on maternal fetal evaluated regression models adjustments for patient hospital factors, including admission...
Abstract Background The burden of cirrhosis on the healthcare system is substantial and growing. Our objectives were to estimate readmission rates hospitalization costs as well identify risk factors for 90‐day in patients with cirrhosis. Methods We conducted a weighted analysis 2014 Nationwide Readmission Database adult cirrhosis‐related complications United States assessed at 30, 60 90 days post‐index hospitalization. Predictors readmissions identified using regression models adjusting...
<h3>Background:</h3> Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) account for a growing proportion of cases, there is need to better understand future burden. We used modelling framework forecast the burden NAFLD NASH Canada. <h3>Methods:</h3> Markov model fibrosis progression from stage F0 (no fibrosis) F4 (compensated cirrhosis) subsequent decompensated cirrhosis, hepatocellular carcinoma, transplantation liver-related death among Canadians with 2019...
Abstract Risk-adjusted health outcomes are often used to measure the quality of hospital care, yet optimal approach in patients with liver disease is unclear. We sought determine whether assessments illness severity, defined as risk for in-hospital mortality, vary across methods cirrhosis. identified 258,731 cirrhosis hospitalized Nationwide Inpatient Sample between 2002 and 2005. The performance four common adjustment (the Charlson/Deyo Elixhauser comorbidity algorithms, Disease Staging,...