A5076049648- Psoriasis: Treatment and Pathogenesis
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- Tryptophan and brain disorders
- Microscopic Colitis
- COVID-19 Pandemic Impacts
- COVID-19 epidemiological studies
- Spondyloarthritis Studies and Treatments
- Acne and Rosacea Treatments and Effects
- Immunotherapy and Immune Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Cutaneous Melanoma Detection and Management
- Pharmaceutical studies and practices
- CAR-T cell therapy research
- Rheumatoid Arthritis Research and Therapies
- Mental Health Treatment and Access
- Skin Protection and Aging
- Chronic Disease Management Strategies
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Ocular Oncology and Treatments
- Vaccine Coverage and Hesitancy
- melanin and skin pigmentation
- Attention Deficit Hyperactivity Disorder
University of Calgary
2013-2024
Queensway-Carleton Hospital
2017-2018
York University
2018
University of Ottawa
2018
South Health Campus
2017
Objective Depression is associated with IBD, but the effect of antidepressants on IBD has been sparsely studied. We assessed impact depression and antidepressant therapies development IBD. Design The Health Improvement Network (THIN) was used to identify a cohort patients new-onset from 1986 2012. THIN who did not meet defining criteria for were part referent group. outcome incident Crohn’s disease (CD) or ulcerative colitis (UC). Cox proportional hazards modelling performed evaluate rate UC...
A bidirectional relationship exists between epilepsy and depression. However, any putative biological gradient depression severity the risk of epilepsy, degree to which mediates influence independent factors for has yet be examined.To determine effect on seizure outcomes.An observational study a population-based primary care cohort (all patients free prevalent at 18-90 years age who were active after Acceptable Mortality Reporting date in The Health Improvement Network database)...
The factors that contribute to the development of psoriatic arthritis (PsA) among patients with psoriasis are not well known; however, systemic inflammation is believed be important. On basis recent laboratory work demonstrating major depressive disorder (MDD) associated increased inflammation, we hypothesized who develop MDD at risk subsequently developing PsA. We utilized Health Improvement Network, a primary care medical records database, identify 73,447 individuals psoriasis. Patients...
Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of several solid tumor types. However, as patient outcomes are heterogeneous, clinical tools to aid in prognostication needed. The Lung Prognostic Index (LIPI) correlates with patients non-small cell lung cancer (NSCLC) treated ICI, but its applicability beyond NSCLC is poorly defined. We sought determine whether LIPI associated overall survival (OS), progression-free (PFS) and objective response rate (ORR) a...
Major depressive disorder (MDD) is associated with increased levels of systemic proinflammatory cytokines, including tumour necrosis factor alpha. As these cytokines are pathogenic in autoimmune diseases such as rheumatoid arthritis (RA), our aim was to explore on a population-level whether MDD increases the risk developing RA.A retrospective cohort study conducted using The Health Improvement Network (THIN) database (from 1986 2012). Observation time recorded for both and referent cohorts...
<h3>Importance</h3> Alopecia areata (AA) is an autoimmune disease characterized by hair loss that can impose a substantial psychological burden on patients, including major depressive disorder (MDD), yet many patients report mental health symptoms prior to the onset of AA. As such, there may be association between MDD and AA acts in both directions. <h3>Objective</h3> To assess bidirectional <h3>Design, Setting, Participants</h3> This population-based retrospective cohort study included 10...
Atopic Dermatitis (AD) and psoriasis (PsO) are two frequent dermatologic conditions that may co-occur in a cluster of patients, yet current understanding how these relate to one-another remains poorly understood. One way better understand their relationship is through process called phenotypic switching, where AD PsO can turn into one another. We utilized pharmacovigilance-based epidemiological approach this phenomenon. By generating adverse event-related disproportionality signals for...
Background Depression is prevalent in primary biliary cholangitis (PBC) patients. Our aims were to examine the effects of depression and antidepressants on hepatic outcomes PBC Methods We used UK Health Improvement Network database identify patients between 1974 2007. outcome was one three clinical events: decompensated cirrhosis, liver transplantation death. assessed each class antidepressant medication adjusted multivariate Cox proportional hazards models independent predictors outcomes....
Emergency department efficiency is a priority across Canada. In the United States, scribes may increase number of patients seen per hour physician; however, Canadian data are lacking. We sought to implement in emergency with hypothesis that would physician.We conducted 4-month quality improvement pilot study community Ottawa, Ontario. Data collection began January 2015 after scribe training. Physicians received shifts and without for period 4 months. Across study, mean was determined each...
OBJECTIVES: We assessed the association of smoking at diagnosis inflammatory bowel disease (IBD) on need for an intestinal resection. METHODS: The Health Improvement Network was used to identify inception cohort Crohn's (n=1519) and ulcerative colitis (n=3600) patients from 1999–2009. Poisson regression explored temporal trends proportion newly diagnosed IBD who never smoked before their risk surgery within 3 years diagnosis. Cox proportional hazard models between surgery, effect...
The government of India implemented social distancing interventions to contain the COVID-19 epidemic. However, effects these on epidemic dynamics are yet be understood. Rates laboratory-confirmed infections per day and effective reproduction number (Rt ) were estimated for 7 periods (Pre-lockdown, Lockdown Phases 1 4 Unlock 1-2) according nationally with phased relaxation. Adoption was using Google mobility data. Estimates at national level 12 Indian states most affected by presented. Daily...
Management of coronavirus disease 2019 (COVID-19) in India is a top government priority. However, there lack COVID-19 adjusted case fatality risk (aCFR) estimates and information on states with high aCFR. Data cases deaths the first pandemic wave 17 state-specific geodemographic, socio-economic, health comorbidity-related factors were collected. State-specific aCFRs estimated, using 13-day lag for fatality. To estimate country-level aCFR wave, state meta-analysed based inverse-variance...
Knee osteoarthritis (OA) progression has been linked to increased peak external knee adduction moments (KAMs). Although some trials have attempted reduce pain and improve function in OA by reducing KAMs with a wedged footwear insole intervention, KAM reduction not specifically controlled for trial designs, potentially explaining the mixed results seen literature. Therefore, primary purpose of this is identify effects reduced on function. Forty-six patients radiographically confirmed...
Pyoderma gangrenosum is an ulcerating disease associated with a high degree of morbidity and mortality. Currently, little known about the pathophysiology pyoderma gangrenosum, though it has been linked to increased levels inflammatory cytokines including interleukin-23. As rare disease, evidence for treatment dependent on reporting cases successful therapies. Here, we describe case developing lateral leg medically complex 47-year-old male already chronic immunosuppressive therapy, who...
Little is known about the pattern of service receipt and outcomes from clinics implementing best practice guidelines in child mental health. This study aimed to determine these variables for a clinic that implemented an attention-deficit/hyperactivity disorder (ADHD) treatment guideline proposed by Children's Medication Algorithm Project (CMAP).Secondary analyses medical record extracts were conducted children who received 2007 2012 specialty linked public children's hospital Canada....